ABSTRACT
Ultrastructure of atrial cardiomyocytes in adrenalin myocardiodystrophy was studied in white rat experiments. Morphometrically, there was a reduced number of mitochondria and secretory granules in the atrial muscular cells, space characteristics of cardiomyocytes and their nuclei increased. The above rearrangement of the atrial cardiomyocytes indicates that adrenalin myocardiodystrophy is associated with a decline in synthetic and secretory function of the test cardiac muscular cells.
Subject(s)
Cardiomyopathies/physiopathology , Epinephrine/physiology , Heart Atria/metabolism , Animals , Cardiomyopathies/pathology , Heart Atria/pathology , Male , RatsABSTRACT
The effects of transcutaneous magnetolaser radiation of the liver, blood alone and in combination on bile secretion and composition were studied in intact rats. Hepatocytes activation was noted in all the above variants. Magnetolaser impact on both the liver and blood intensified bile production under less total density of the radiation energy. Bile and direct bilirubin secretion increased. Excretion of bile acids enhances selectively, while that of cholesterol diminished. There may be mutual potentiation, summing and selectivity of the effects arising in combined magnetolaser radiation of the liver and blood.
Subject(s)
Bile/radiation effects , Blood/radiation effects , Lasers , Liver/radiation effects , Magnetics , Animals , Bile/chemistry , Bile/metabolism , Liver/metabolism , Male , RatsABSTRACT
Effects of 14-21-day courses of reducing diet on function of T- and B-system immunity were studied in 35 patients with primary osteoarthrosis, while effects of food deprivation on nonspecific effector system of immune defense and local immune reactions were studied in experiment on R. Altman arthrosis model. It was proved that due to the above fasting the articular syndrome by clinical and laboratory criteria was much relieved. This positive effect is explained by modulating action of diet therapy on T- and B-immunity in combination with stimulation of activity of nonspecific effector system of immune defense. The dependence of the above changes on the treatment period are determined.
Subject(s)
Diet, Reducing , Immune System Diseases/diet therapy , Osteoarthritis/diet therapy , Adult , Aged , Animals , Antibody Formation , Chronic Disease , Female , Food Deprivation/physiology , Humans , Immune System Diseases/etiology , Immune System Diseases/immunology , Immunity, Cellular , Male , Middle Aged , Osteoarthritis/complications , Osteoarthritis/immunology , Rabbits , Time FactorsABSTRACT
Immunofluorescence was used to study the count of joint synovial membrane cells producing immunoglobulins of major classes (A, M, G) in 30 rabbits on a model of experimental arthrosis and the effects of rumalone, rumalone + indomethacin, and food deprivation. Clinically, the levels of immune responses in patients with primary osteoarthrosis were judged from the content of rumalone-sensitive serum antibodies. The development of experimental arthrosis was found to be followed by a substantial increase in the count of synovial membrane cells locally elaborating immunoglobulins chiefly G and M. With this, the use of pathogenetically substantiated therapy with chondroprotective agents produced a slight effect on the degree of local immune response impairments. Correction of the latter may be made with indomethacin and food deprivation in the experiment, as well as with indomethacin and microwave resonance therapy in the clinical setting.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Immunoglobulins/biosynthesis , Indomethacin/therapeutic use , Osteoarthritis/immunology , Animals , Drug Therapy, Combination , Osteoarthritis/drug therapy , RabbitsABSTRACT
The amount of plasma cells synthesizing different class immunoglobulins in the gallbladder wall in 9 practically healthy people and in 19 patients with different forms of cholecystitis was studied by a complex of histological, histochemical and immunofluorescent methods. It was established that catarrhal cholecystitis was accompanied by activated production of immunoglobulins of all classes by plasmocytes of the gallbladder wall. In patients with destructive forms of cholecystitis the level of secretory immunoglobulin A was substantially decreased as well as the amount of plasmocytes synthesizing IgA. The amount of immunocytes producing IgM and IgG became disproportionally greater, there appeared immune IgM complexes and IgG and IgG in the wall of blood vessels and perivascular stroma. The author considers that local immune reactions play an important role in protection of the gallbladder mucosa and pathomorphogenesis of cholecystitis.
Subject(s)
Cholecystitis/immunology , Female , Fluorescent Antibody Technique , Gallbladder/immunology , Humans , Immunoglobulin A/analysis , Immunoglobulin A, Secretory/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Immunoglobulins/analysis , Mucous Membrane/immunology , Plasma Cells/immunology , T-Lymphocytes/immunologyABSTRACT
The functional and structural changes in the liver of white rats both low- and high-resistant to hypoxia, have been studied using the biochemical and morphological methods. It has been found that intensity and degree of the liver injury in experimental toxic hepatitis depend on the systemic resistance to hypoxia. The functional and morphological changes in the injured liver have been found to be less pronounced in the high-resistant rats as compared with those in the low-resistant animals.
Subject(s)
Chemical and Drug Induced Liver Injury/physiopathology , Hypoxia/physiopathology , Alanine Transaminase/metabolism , Animals , Aspartate Aminotransferases/metabolism , Chemical and Drug Induced Liver Injury/complications , Chemical and Drug Induced Liver Injury/metabolism , Chemical and Drug Induced Liver Injury/pathology , Hypoxia/complications , Lipid Peroxidation , Liver Function Tests , Male , RatsSubject(s)
Cholinesterase Inhibitors/toxicity , Disease Models, Animal , Erythrocytes/drug effects , Fetal Death/chemically induced , Hydroxylamines/toxicity , Viscera/drug effects , Water Pollutants, Chemical/toxicity , Water Supply/standards , Animals , Atrophy/chemically induced , Cholinesterase Inhibitors/analysis , Cholinesterase Inhibitors/standards , Dose-Response Relationship, Drug , Erythrocyte Count/drug effects , Erythrocytes/pathology , Female , Guinea Pigs , Hydroxylamine , Hydroxylamines/administration & dosage , Hydroxylamines/analysis , Hydroxylamines/standards , Male , Maximum Allowable Concentration , Mice , Pregnancy , Rats , Sulfates/analysis , Sulfates/standards , Sulfates/toxicity , Ukraine , Viscera/pathology , Water Pollutants, Chemical/analysisABSTRACT
A complex of functional and morphologic methods was used to study the specific features of adaptation processes in various parts of the heart after right pneumonectomy in chronic experiments on 84 male albino rats with pulmonary hypertension. Various compensatory-adaptational processes developed in different parts of the myocardium, but increase of the mass prevailed with predominant hypertrophy of the right ventricle (76.2%). Study of the heart rhythm showed that prolonged hyperfunction of the cardiac muscle was attended by various types of regulatory relations with prevalence of dysregulation and vagotonic type rhythmic activity of the heart, which was evidence of significant reduction of the adaptative properties of the organism.
Subject(s)
Heart/physiopathology , Lung/physiology , Animals , Cardiomegaly/physiopathology , Heart Rate/physiology , Hypertension, Pulmonary/physiopathology , Male , Pneumonectomy , Postoperative Period , RatsABSTRACT
By means of a complex morphometrical method special quantitative parameters of cardiomyocytes have been studied in the cardiac parts of 37 dogs, 6 months after right-sided pulmonectomy, and of 12 control dogs. The cardiac hyperfunction is accompanied with an increased mass of the heart's parts, hypertrophy of the right ventricle and right atrium dominating. Hypertrophy of myocardial parts takes place mainly at the expense of the increasing length and width of cardiomyocytes. This causes disorganization and disorder of morphological systems and an essential decrease in compensatory possibilities of the hyperfunctioning heart parts.
Subject(s)
Heart Failure/pathology , Hypertension, Pulmonary/pathology , Myocardium/pathology , Animals , Cardiomegaly/pathology , Disease Models, Animal , Dogs , Histological Techniques , PneumonectomyABSTRACT
Adaptation of the parts of myocardium of 18 white rats to the physical static loadings during two months have been studied by means of morphometric and histological methods. Physical loadings cause hyperfunction and hypertrophy of all chambers of the heart with a predominant hypertrophy of the right ventricle, right auricle and dilatation of these cavities. The heterogeneous changes of the myocardium were found on the organic level.
Subject(s)
Adaptation, Physiological , Heart/physiology , Physical Exertion , Animals , Cardiomegaly/etiology , Cardiomegaly/physiopathology , Heart/anatomy & histology , Male , Organ Size , Rats , Rats, Inbred Strains , Time FactorsABSTRACT
By means of morphometrical and histological methods hearts of 84 white rats have been studied in 3 months after right-sided pulmonectomy. Cardiac hyperfunction resulted is accompanied with an increased mass of its parts, where hypertrophy of the right ventricle and atrium predominate. Hypertrophy of myocardial parts takes place mainly at the expense of increasing length and width of cardiomyocytes; this causes disorganization and disordering of morphological systems and an essential decrease of compensatory possibilities of the hyperfunctioning heart parts.
Subject(s)
Cardiomegaly/pathology , Heart/physiopathology , Hypertension, Pulmonary/physiopathology , Myocardium/pathology , Animals , Cardiomegaly/etiology , Heart Atria , Heart Septum , Heart Ventricles , Hypertension, Pulmonary/complications , Male , RatsABSTRACT
The effect of reclaimed potable water on cardiac rhythms of 190 noninbred white male rats was investigated in a 6-month experiment. The water contained 25.0 to 100.0 mg/l sodium and/or 2.5 to 10.0 mg/l potassium. The water containing 100 mg/l sodium and 10 mg/l potassium caused changes in both compartments of the autonomic nervous system controlling cardiac rhythms. The water containing 75.0 and 50.0 mg/l sodium and 7.5 and 5.0 mg/l potassium produced insignificant changes in cardiac rhythms. The water containing lower concentrations of sodium (25.0 mg/l) and potassium (2.5 mg/l) had no effect.
Subject(s)
Heart Rate/drug effects , Potassium/pharmacology , Sodium/pharmacology , Water/analysis , Animals , Autonomic Nervous System/drug effects , Ecological Systems, Closed , Male , RatsABSTRACT
The experiment has been performed in 124 non-inbred dogs by means of a complex of morphometrical methods in order to study compensatory-adaptive processes in the heart after pulmonary resection various in its volume. After 58% resection, and especially after 67-75% resection of the lung mass, a stable pulmonary arterial hypertension appears; it results in development of a chronic cor pulmonale and terminates in its decompensation. Application of extrapulmonary arterio-venous anastomosis, before 67-75% of the pulmonary parenchyma is resected, decreases hypertension in the pulmonary circulation, improves adaptive changes of the heart in the newly formed conditions of hemodynamics, preventing development of its failure.
