ABSTRACT
The aim of research is to estimate the functional state of the cardiovascular system in children with gastroesophageal reflux disease (GERD) with the help of Holter monitoring. 117 children of school age were examined: 69 children with GERD and 48 children with chronic gastroduodenitis. All children passed esophagogastroduodenoscopy, 24-hour pH-monitoring, electrocardiography and Holter monitoring. According to Holter monitoring data it was revealed that children with GERD had increased low-frequency components of frequency domain analyses, increased number of nocturnal PVCs and increased time of enhanced dispertion periods. Holter monitoring in patients with GERD can be used to detect preclinical ectopic rhythm, to evaluate autonomic dysfunction by frequency domain analyses, to predict nocturnal symptoms.
Subject(s)
Cardiovascular Physiological Phenomena , Cardiovascular System/physiopathology , Electrocardiography, Ambulatory , Gastroesophageal Reflux/physiopathology , Adolescent , Case-Control Studies , Child , Female , Humans , MaleSubject(s)
Blood Pressure/drug effects , Diabetes Mellitus, Type 1 , Diabetic Neuropathies/therapy , Heart Rate/drug effects , Metabolism/drug effects , Taurine/pharmacology , Adolescent , Chemoprevention , Child , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/metabolism , Diabetic Neuropathies/metabolism , Diabetic Neuropathies/physiopathology , Dietary Supplements , Humans , Monitoring, Physiologic , Secondary Prevention , Treatment OutcomeABSTRACT
The group of 141 school-year children with bronchial asthma was examined. The condition of upper gastrointestinal tract was assessed. Gastroesophageal reflux disease was revealed in 94 children (66.7%). Dyspepsia, mucosal damage and changes of 24-hour pH monitoring data were more intensive in acute period of asthma and in children with severe asthma. Acid supression in the complex therapy of gastroesophageal reflux disease permited to minimise symptoms of dyspepsia and improve the pH monitoring data.
Subject(s)
Anti-Asthmatic Agents/therapeutic use , Asthma/complications , Gastroesophageal Reflux/diagnosis , Proton Pump Inhibitors/therapeutic use , Adolescent , Anti-Asthmatic Agents/administration & dosage , Asthma/drug therapy , Child , Drug Therapy, Combination , Esophagus/drug effects , Esophagus/pathology , Esophagus/physiology , Female , Gastric Acid/chemistry , Gastric Acid/metabolism , Gastric Acidity Determination/instrumentation , Gastroesophageal Reflux/complications , Gastroesophageal Reflux/drug therapy , Gastroesophageal Reflux/pathology , Humans , Hydrogen-Ion Concentration , Male , Monitoring, Ambulatory , Proton Pump Inhibitors/administration & dosage , Severity of Illness Index , Treatment OutcomeABSTRACT
Children with rheumatoid arthritis in remission or minimal activity of the disease were examined after sanatorium treatment. It was established that health resort factors had produced a positive capillarotropic effect in rheumatoid arthritis, i.e. capillarotropic insufficiency, tissue hypoxia, inflammation and proteolysis reduced; microcirculation returned to normal.
