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Gig Sanit ; (11): 7-9, 1989 Nov.
Article in Russian | MEDLINE | ID: mdl-2625229

ABSTRACT

Through taking into account frequency of sister chromatid metabolisms and chromosome aberrations in bone marrow cells of animals it is demonstrated that under long-term body intake chromium in a wide range of doses can produce mutagenic effect. When assessing chromium mutagenic effect in vivo it is also shown that the test on sister chromatid metabolism is more sensitive than the test on chromosome aberrations in bone marrow cells.


Subject(s)
Bone Marrow/drug effects , Chromates/toxicity , Chromosome Aberrations , Potassium Dichromate/toxicity , Sister Chromatid Exchange/drug effects , Water Pollutants, Chemical/toxicity , Water Pollutants/toxicity , Animals , Bone Marrow/ultrastructure , Dose-Response Relationship, Drug , Drinking , Mice , Mutation , Potassium Dichromate/administration & dosage
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