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J Asian Nat Prod Res ; 12(2): 106-12, 2010 Feb.
Article in English | MEDLINE | ID: mdl-20390751

ABSTRACT

Two new xanthones, pyranocycloartobiloxanthone A (1) and dihydroartoindonesianin C (2), were isolated from the stem bark of Artocarpus obtusus Jarrett by chromatographic separation. Their structures were determined by using spectroscopic methods and comparison with known related compounds. Pyranocycloartobiloxanthone A (1) showed strong free radical scavenging activity by using DPPH assay as well as cytotoxicity towards K562, HL-60, and MCF7 cell lines.


Subject(s)
Artocarpus/chemistry , Free Radical Scavengers/isolation & purification , Plants, Medicinal/chemistry , Xanthones/isolation & purification , Biphenyl Compounds/pharmacology , Drug Screening Assays, Antitumor , Free Radical Scavengers/chemistry , Free Radical Scavengers/pharmacology , Malaysia , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Picrates/pharmacology , Plant Bark/chemistry , Xanthones/chemistry , Xanthones/pharmacology
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