Ambulatório de Gênero e Sexualidades (AmbGen/ HC/ UNICAMP): relato da experiência do serviço / Gender and Sexualities Outpatient Clinic (AmbGen/ HC/UNICAMP): report of the service experience

0 Ambulatório de Género e Sexualidades (AmbGen) do Hospital das Clinicas da Universidade Estadual de Campinas é um dos poucos dispositivos públicos que acolhem população da infância e adolescência com variabilidade de género. A psiquiatria e psicologia investigam transtornos mentais, desencadeadores do sofrimento psíquico, disforias relacionados à incongruência de gênero e, no caso de crianças e adolescentes, acolhem as familías buscando compreensão da dinâmica familiar, esclarecimento de duvidas e estigmas. A intervenção hormonal na adolescência é possível em dois momentos: no inicio da puberdade, através de terapia medicamentosa visando blogueio puberal, e hormonização cruzada. A adequação corporal & identidade de género da pessoa trans, através da hormonização, é desejada pela maior parte dos adultos atendidos. A arteterapia realiza atendimentos nos quais busca fornecer padrões adequados à questões relevantes, utilizando- se de modalidades expressivas e vivências de processos criativos, uma maneira terapêutica diferenciada que propicia um ambiente acolhedor por um viés artístico. Características de género e voz são muito abrangentes. Sendo assim, a terapia fonoaudiológica a pessoas trans não se restringe apenas a produção vocal, mas também se relaciona a outros aspectos da comunicação e do discurso.

Técnica de punción de verde de indocianina intravesicular para conseguir una visión crítica de seguridad durante la colecistectomía por laparoscopia / Direct gallbladder Indocyanine Green injection technique to achieve critical view of safety in laparoscopic cholecystectomy

Introducción: La lesión de vía biliar continúa siendo una de las complicaciones más graves tras la colecistectomía. El objetivo de este estudio es mostrar una técnica sencilla para la administración del verde de indocianina intravesicular, consiguiendo una visión crítica óptima durante la colecistectomía laparoscópica. Métodos: Se estudiaron prospectivamente 23 pacientes con administración intravesicular de verde de indocianina con aguja fina utilizando una técnica fácilmente reproducible. Resultados: Se reportó la visión de las estructuras biliares antes y después de su administración. La visión crítica de seguridad se consiguió en todos los casos. Conclusiones: La administración intravesicular de verde indocianina mediante la técnica que describimos es sencilla, efectiva y consigue una colangiografía por fluorescencia en tiempo real y una visión crítica de seguridad óptima, disminuyendo así el riesgo de lesión biliar. (AU)

Introduction: Bile duct injury is one of the most severe complications after cholecystectomy. The aim of this study is to demonstrate how with a simple technique, an optimal critical view may be achieved by injecting indocyanine green directly into the gallbladder. Methods: Twenty-three patients were prospectively studied in which direct gallbladder injection of indocyanine green during laparoscopy was administered with a fine needle using an easily reproducible technique. Results: Biliary tree identification was reported before and after injection. Critical view of safety was achieved in all cases. Conclusions: Our technique of direct gallbladder injection of indocyanine green is simple, efficient and shows a real time fluorescent cholangiography and an optimal critical view of safety decreasing the risk for bile duct injury. (AU)

Direct gallbladder indocyanine green injection technique to achieve critical view of safety in laparoscopic cholecystectomy.

INTRODUCTION: Bile duct injury is one of the most severe complications after cholecystectomy. The aim of this study is to demonstrate how with a simple technique, an optimal critical view may be achieved by injecting indocyanine green directly into the gallbladder. METHODS: Twenty-three patients were prospectively studied in which direct gallbladder injection of indocyanine green during laparoscopy was administered with a fine needle using an easily reproducible technique. RESULTS: Biliary tree identification was reported before and after injection. Critical view of safety was achieved in all cases. CONCLUSIONS: Our technique of direct gallbladder injection of indocyanine green is simple, efficient and shows a real time fluorescent cholangiography and an optimal critical view of safety decreasing the risk for bile duct injury.

Direct gallbladder Indocyanine Green injection technique to achieve critical view of safety in laparoscopic cholecystectomy. / Técnica de punción de verde de indocianina intravesicular para conseguir una visión crítica de seguridad durante la colecistectomía por laparoscopia.

INTRODUCTION: Bile duct injury is one of the most severe complications after cholecystectomy. The aim of this study is to demonstrate how with a simple technique, an optimal critical view may be achieved by injecting indocyanine green directly into the gallbladder. METHODS: Twenty-three patients were prospectively studied in which direct gallbladder injection of indocyanine green during laparoscopy was administered with a fine needle using an easily reproducible technique. RESULTS: Biliary tree identification was reported before and after injection. Critical view of safety was achieved in all cases. CONCLUSIONS: Our technique of direct gallbladder injection of indocyanine green is simple, efficient and shows a real time fluorescent cholangiography and an optimal critical view of safety decreasing the risk for bile duct injury.

Laparoscopic Right Adrenalectomy in a Large Right Adrenal Oncocytic Carcinoma.

BACKGROUND: Adrenocortical carcinomas are rare and aggressive tumors. The recently described oncocytic subtype has been reported approximately 40 times in the literature.1 In this video, we describe an unusual case of a large adrenal oncocytic carcinoma, its minimally invasive approach, and its anatomopathological features. CASE DESCRIPTION: A 43-year-old male presented to the emergency room with acute abdominal pain and fever. Blood tests showed 20,000 white blood cells and a reactive C-protein of 25. Tomography showed a large right adrenal tumor with necrosis. Antibiotics were started at the intensive care unit. A complete study showed normal tests, including hormones, cortisol, and metanephrines. At the multidisciplinary team meeting it was decided to perform a right transabdominal laparoscopic adrenalectomy. The tumor was approached from the medial side to the lateral side, always controlling the inferior vena cava. Indocyanine green was used to identify vascular structures. Anatomical pathology revealed a 15 cm lesion corresponding to a malignant adrenal oncocytic carcinoma according to the modified Lin-Weis-Bisceglia criteria.2 The patient was discharged without complications on the fifth day. He is receiving mitotane and is disease-free 5 months after surgery. CONCLUSIONS: Oncocytic subtype is a rare entity described only a few times in the literature. Surgical treatment is of choice due to its curative potential, and the open versus laparoscopic approach will be chosen depending on the size of the tumor and the surgeon's experience. It is believed that this subtype may have a less aggressive behavior than the typical adrenal carcinoma,1 therefore its better understanding may help to define therapeutic decisions and prognosis in the future.

Preservación de corteza adrenal funcionante. Una buena razón para realizar un abordaje endoscópico retroperitoneal posterior / Functional adrenal cortex preservation: A good reason for posterior retroperitoneal endoscopic approach

INTRODUCCIÓN: La adrenalectomía con preservación cortical se indica como tratamiento del feocromocitoma bilateral hereditario y esporádico, en casos de bajo riesgo de malignidad, para reducir la posibilidad de insuficiencia suprarrenal asumiendo la eventualidad de una recidiva local. El objetivo del estudio es analizar los resultados funcionales de la adrenalectomía parcial por vía endoscópica retroperitoneal en pacientes monoadrenales o que necesiten una adrenalectomía bilateral. MÉTODOS: Entre enero de 2015 y febrero de 2016 se incluyeron de forma prospectiva pacientes con feocromocitoma asociado a mutaciones con bajo riesgo para malignidad, que aceptaron participar en el estudio. Todos fueron operados por cirujanos especialmente entrenados en este tipo de cirugía, utilizando la misma técnica quirúrgica. Se recogieron variables demográficas y características clínicas, realizando posteriormente el análisis descriptivo de dichas variables. RESULTADOS: Se registraron un total de 6 pacientes, cuatro asociados al síndrome MEN tipo 2 y dos en contexto del síndrome VHL. No fue precisa ninguna conversión a abordaje laparoscópico o abierto y tampoco complicaciones postoperatorias, la estancia hospitalaria media fue de 2,5 días. Se logró la preservación de corteza adrenal funcionante sin requerimiento corticoideo en 5 (83%) de 6 casos. Con un seguimiento medio de 26,2 ± 6 meses, estos 5 pacientes presentan una función adrenal conservada sin aporte hormonal sustitutivo. CONCLUSIONES: La adrenalectomía con preservación cortical por vía endoscópica retroperitoneal, en manos expertas, es segura y factible para el tratamiento del feocromocitoma hereditario y esporádico en contexto de baja malignidad, permitiendo evitar la necesidad de aporte corticoideo en la mayoría de los casos

INTRODUCTION: Cortical-sparing adrenalectomy is a suitable treatment for hereditary and sporadic bilateral pheochromocytoma, in cases of low risk of malignancy, to reduce the possibility of adrenal insufficiency assuming the chance of local recurrence. The aim of the study is to analyze the functional results of partial adrenalectomy by retroperitoneal endoscopic approach in single-adrenal patients or patients requiring bilateral adrenalectomy. METHODS: Prospective study between January 2015 and February 2016 including pheochromocytoma patients diagnosed with low risk of malignant mutations. All patients agreed to be included in the study. Experienced endocrine surgeons who have been trained in minimally invasive endocrine surgery performed the procedure using the same surgical technique. Demographic variables and clinical characteristics were collected, subsequently carrying out the descriptive analysis of the data. RESULTS: A total of 6 patients were registered, four associated with MEN type 2 syndrome and two in the context of VHL syndrome. Retroperitoneoscopic resection was performed without laparoscopic or open conversion and no postoperative complications; the average hospital stay was 2.5 days. Preservation of the functional cortex without corticosteroids was achieved in 5 (83%) of out 6 cases with a follow-up of 26.2 ± 6 months. Today, these 5 patients have a preserved adrenal function without hormone replacement. CONCLUSIONS: Cortical-sparing adrenalectomy by the retroperitoneal endoscopic approach, in expert hands, is safe and feasible for the treatment of hereditary and sporadic pheochromocytoma in a context of low malignancy, making it possible to avoid the need for corticoid replacement in most cases

Functional adrenal cortex preservation: A good reason for posterior retroperitoneal endoscopic approach. / Preservación de corteza adrenal funcionante. Una buena razón para realizar un abordaje endoscópico retroperitoneal posterior.

INTRODUCTION: Cortical-sparing adrenalectomy is a suitable treatment for hereditary and sporadic bilateral pheochromocytoma, in cases of low risk of malignancy, to reduce the possibility of adrenal insufficiency assuming the chance of local recurrence. The aim of the study is to analyze the functional results of partial adrenalectomy by retroperitoneal endoscopic approach in single-adrenal patients or patients requiring bilateral adrenalectomy. METHODS: Prospective study between January 2015 and February 2016 including pheochromocytoma patients diagnosed with low risk of malignant mutations. All patients agreed to be included in the study. Experienced endocrine surgeons who have been trained in minimally invasive endocrine surgery performed the procedure using the same surgical technique. Demographic variables and clinical characteristics were collected, subsequently carrying out the descriptive analysis of the data. RESULTS: A total of 6 patients were registered, four associated with MEN type 2 syndrome and two in the context of VHL syndrome. Retroperitoneoscopic resection was performed without laparoscopic or open conversion and no postoperative complications; the average hospital stay was 2.5 days. Preservation of the functional cortex without corticosteroids was achieved in 5 (83%) of out 6 cases with a follow-up of 26.2 ± 6 months. Today, these 5 patients have a preserved adrenal function without hormone replacement. CONCLUSIONS: Cortical-sparing adrenalectomy by the retroperitoneal endoscopic approach, in expert hands, is safe and feasible for the treatment of hereditary and sporadic pheochromocytoma in a context of low malignancy, making it possible to avoid the need for corticoid replacement in most cases.

Benefits of laparoscopic liver resection in patients with hepatocellular carcinoma and portal hypertension: a case-matched study.

BACKGROUND: The advantages of laparoscopy over open liver resection in patients with cirrhosis have been widely demonstrated. On the other hand, information on the role of minimally invasive liver surgery in the presence of clinically significant portal hypertension (CSPH) is scarce. The aim of this study was to evaluate the role of laparoscopic liver resection in selected cirrhotic patients with CSPH. METHODS: A retrospective case-control study of cirrhotic patients with hepatocellular carcinoma who were treated with laparoscopic liver resection was conducted from December 2005 to April 2016. A total of 45 patients were included. Patients were divided into two groups according to the presence or absence of clinically significant portal hypertension. Fifteen cirrhotic patients with CSPH were matched with 30 patients without CSPH. RESULTS: Overall, there were no differences in intraoperative results. No conversion to open surgery occurred in the CSPH group, and 3 patients were converted in the Non-CSPH group (0 vs. 10% p = 0.57). Only 2 (7%) patients in the Non-CSPH group and 1 (7%) in the CSPH group had relevant complications (modified Clavien-Dindo classification III). Two patients in the Non-CSPH group and one in the CSPH group developed transient ascites (7 vs. 7%). Postoperative hospital stay was similar in both groups, with a median of 4 days in the CSPH group and 3 days in the Non-CSPH group (p = 0.37). The median follow-up of the entire cohort was 38 months (range 7-100). Overall survival rates at 1 and 3 years were 100 and 87%, respectively. There was no significant difference between the groups in terms of survival (p = 0.8). CONCLUSION: This initial study showed that laparoscopic resection in patients with CSPH can be performed safely in well-selected patients and expand the current surgical indications in patients with CSPH. Prospective trials with a larger sample size are necessary to confirm these results.

Prevalência de sintomas depressivos em estudantes de medicina / Prevalence of depressive symptoms in medical students

JUSTIFICATIVA E OBJETIVOS: Diversos estudos revelam que os estudantes de Medicina são altamente suscetíveis ao aparecimento de quadros depressivos. Essa maior predisposição parece estar relacionada a diferentes fatores ao longo do curso. A depressão, além de causar grande sofrimento psíquico, pode levar a prejuízos no desempenho acadêmico e nos relacionamentos sociais.O objetivo deste estudo foi verificar a prevalência de sintomas depressivos entre os estudantes de Medicina e avaliar como eles se comportam de acordo com o sexo, idade e período do curso. MÉTODO: O estudo foi realizado no segundo semestre de 2009 com 400 alunos devidamente matriculados no curso de Medicina. Os alunos foram divididos em três grupos distintos: o grupo A formado por alunos do 1º e 2º anos, o grupo B por alunos do 3º e 4º anos e o grupo C por alunos do 5º e 6º anos. Foi utilizado o Inventário de Depressão de Beck que é uma medida de autoavaliação dos sintomas da depressão. RESULTADOS: A idade média foi de 22,56 anos e a pontuação média geral de 5,77, sendo 5,11 para os homens e 6,29 para as mulheres. As três questões com maior pontuação foram as de número 8, 5 e 17. CONCLUSÃO: Autoacusação, culpa e fadiga foram os três sintomas depressivos de maior frequência com alta concordância entre os grupos. Não houve diferença significante em relação à quantidade de sintomas depressivos presentes entre os três grupos.

BACKGROUND AND OBJECTIVES: Several studies show that medical students are highly susceptible to the onset of depression.This increased predisposition seems to be related to different stressors throughout the course. Depression, besides causing great psychological distress, may lower academic performance and social relationships. The aim of this study is to identify theprevalence of depressive symptoms among medical students of the Medical School and assess how they change according to gender,age and period of the course. METHOD: The study was conducted during the second half of 2009 with 400 students duly enrolled in medical school. Students were divided into three different groups. Group A is formedby students of the 1st and 2nd year, group B for studentsin 3rd and 4th year students and group C for the 5th and 6th years. We used the Beck Depression Inventory: a self-assessmen tof depressive symptoms, RESULTS: The mean age was 22.56 years and the overall average score was 5.77, and 5.11 for men and 6.29 for women. The three questions highest scored were questions 8, 5 and 17. CONCLUSION: Self-blame, guilt and fatigue were the most frequent among the depressive symptoms - with high agreement between groups. There was no significant difference in the quantityof depressive symptoms among the three groups.