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1.
Chem Commun (Camb) ; 54(53): 7290-7293, 2018 Jun 28.
Article in English | MEDLINE | ID: mdl-29863206

ABSTRACT

Metal-organic polyhedral cages substituted with paraffinic side chains were designed as solution-processable porous modules, which provide soft materials possessing self-organized cavity structures with three-dimensional molecular order in a lyotropic mesophase. The macroscopic shape of the resulting soft materials can be easily modified through solution-based processes.

2.
Chem Commun (Camb) ; 54(41): 5209-5212, 2018 May 17.
Article in English | MEDLINE | ID: mdl-29722374

ABSTRACT

Anisotropic dendrimers with bipolar shapes were systematically obtained using a heteroleptic metal-organic polyhedron (MOP) as a robust core scaffold. The structure of one of these polyhedral shapes was unambiguously determined by single-crystal X-ray analysis, which revealed that the bulky dendrons converge to both axial positions of the heteroleptic MOP core.

3.
J Am Chem Soc ; 138(20): 6525-31, 2016 05 25.
Article in English | MEDLINE | ID: mdl-27119553

ABSTRACT

We herein report the divergent and convergent synthesis of coordination star polymers (CSP) by using metal-organic polyhedrons (MOPs) as a multifunctional core. For the divergent route, copper-based great rhombicuboctahedral MOPs decorated with dithiobenzoate or trithioester chain transfer groups at the periphery were designed. Subsequent reversible addition-fragmentation chain transfer (RAFT) polymerization of monomers mediated by the MOPs gave star polymers, in which 24 polymeric arms were grafted from the MOP core. On the other hand, the convergent route provided identical CSP architectures by simple mixing of a macroligand and copper ions. Isophthalic acid-terminated polymers (so-called macroligands) immediately formed the corresponding CSPs through a coordination reaction with copper(II) ions. This convergent route enabled us to obtain miktoarm CSPs with tunable chain compositions through ligand mixing alone. This powerful method allows instant access to a wide variety of multicomponent star polymers that conventionally have required highly skilled and multistep syntheses. MOP-core CSPs are a new class of star polymer that can offer a design strategy for highly processable porous soft materials by using coordination nanocages as a building component.

4.
Bioorg Med Chem Lett ; 14(16): 4339-42, 2004 Aug 16.
Article in English | MEDLINE | ID: mdl-15261298

ABSTRACT

Compounds (6a-e) were synthesized by phosphorylation of hydrophobic perhydroindan derivatives derived from vitamin D(3), and were found to show strong inhibitory activity towards dual-specificity phosphatase Cdc25A (IC(50)=0.7-24.5 microM).


Subject(s)
Enzyme Inhibitors/chemistry , Phosphates/chemistry , cdc25 Phosphatases/antagonists & inhibitors , Enzyme Inhibitors/chemical synthesis , Enzyme Inhibitors/pharmacology
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