ABSTRACT
BACKGROUND: Periodontal disease (PerioD) is a chronic, complex inflammatory condition resulting from the interaction between subgingival dysbiotic bacteria and the host immune response leading to local inflammation. Since periodontal inflammation is characterized by multiple cytokines effects we investigated whether Periodontal Inflamed Surface Area (PISA), a continuous measure of clinical periodontal inflammation is a predictor of composite indexes of salivary cytokines. METHODS AND FINDINGS: In a cross-sectional study of 67 healthy, well-educated individuals, we evaluated PISA and several cytokines expressed in whole stimulated saliva. Two salivary cytokine indexes were constructed using weighted and unweighted approaches based on a Principal Component Analysis [named Cytokine Component Index (CCI)] or averaging the (standardized) level of all cytokines [named Composite Inflammatory Index (CII)]. In regression analysis we found that PISA scores were significantly associated with both salivary cytokine constructs, (CCI: part R = 0.51, p<0.001; CII: part R = 0.40, p = 0.001) independent of age, gender and BMI showing that single scores summarizing salivary cytokines correlated with severity of clinical periodontal inflammation. CONCLUSIONS: Clinical periodontal inflammation may be reflected by a single score encompassing several salivary cytokines. These results are consistent with the complexity of interactions characterizing periodontal disease. In addition, Type I error is likely to be avoided.
Subject(s)
Periodontal Diseases , Periodontitis , Humans , Cytokines , Cross-Sectional Studies , Inflammation , SalivaABSTRACT
Catastrophic preparedness should be incorporated into the dental school curriculum. The experience at New York University College of Dentistry is that a combination of catastrophic preparedness elements integrated within existing courses with a short, meaningful capstone course dedicated to all hazards preparedness can be accomplished successfully and meet proposed competencies for training in the dental curriculum. The roles and responsibilities in catastrophic response preparedness and response of dentists are actively being discussed by the dental profession. An element of that discussion has to include the "what" and "how" of education and training for dentists at the predoctoral level and after dental school graduation. The concepts presented in this article should be debated at all levels of the profession.
Subject(s)
Civil Defense/education , Curriculum , Disasters , Education, Dental , Professional Practice , Schools, Dental , Clinical Competence , Dentists , Disaster Medicine/education , Disaster Planning , Education, Dental, Continuing , Education, Dental, Graduate , Faculty, Dental , Humans , New York , Professional Role , Public Health Practice , Students, Dental , United StatesABSTRACT
This article describes an integrated fourth-year course in catastrophe preparedness for students at the New York University College of Dentistry (NYUCD). The curriculum is built around the competencies proposed in "Predoctoral Dental School Curriculum for Catastrophe Preparedness," published in the August 2004 Journal of Dental Education. We highlight our experience developing the program and offer suggestions to other dental schools considering adding bioterrorism studies to their curriculum.
