[Pathology of inflammatory diseases of the central nervous system--an autopsy analysis 1967-1988]. / Pathologie der entzündlichen Erkrankungen des ZNS--eine Obduktionsanalyse der Jahre 1967-1988.

This paper deals with investigations of CNS-inflammations based on 23,338 autopsies in the period from 1967 to 1988. Inflammatory CNS-findings were observed in 210 cases (0.9 per cent). Their etiology was caused bacterially in 66 per cent and viral infections were found in 20 per cent. Additionally multiple sclerosis appeared in 14 per cent of all CNS-inflammations. The meningitis dominated among the bacterial infections and the leukencephalitis and nekrotizing polioencephalitis of Herpes type among the viral inflammations. The histological classification of the nonbacterial inflammations was difficult or impossible in 9 per cent. A clinical diagnosis was established only in 70 per cent of all cases. Especially babies and patients at the age about 60 or 70 were involved.

[Hypertonic central nervous system complications from the viewpoint of the pathologist]. / Die hypertonischen zentralnervösen Komplikationen aus der Sicht des Pathologen.

Based on 2130 autopsies with a hypertension it is reported on the hypertensive CNS-lesions. The frequency of encephalomalacia was 12%. By 9.7% was founded brain haemorrhages. The relapse rate of haemorrhages was about 5%. The encephalomalacia existed by way of secondary finding in 24.7%, and the haemorrhage in 2.2%. The investigations showed an important arteriosclerosis by 39.8% in haemorrhages and by 51.6% in brain infarct. It was remarkable by the hypertensive brain haemorrhages a dominant right hemisphere.

[Development of current problems regarding perinatal CNS lesions from a neuropathologic viewpoint]. / Zur Entwicklung gegenwärtiger Problematik perinataler ZNS-Schäden aus der Sicht der Neuropathologie.

Perinatal central-nervous-system lesions may be found in as many as one third of all subjects who died before, during, or after the time of birth. Today, hypoxia is considered to be an essential cause of such lesions; in contrast to views held previously, birth trauma, i.e., physical injury to an infant during its delivery, is of minor pathogenetic importance. Neurohistological studies showed that it is especially prolonged hypoxia - in addition to cerebral hemorrhage, damage to the cerebral parenchyma and medullary substance - which can cause lesion of the brain stem. A relatively frequent occurrence are isolated ischemic cerebrospinal nerve cell lesions. Their prognostic dignity in regard to the possible formation of synapses and the problem of damage to the neuroglia are as yet imperfectly understood.