ABSTRACT
OBJECTIVES: Acute myeloid leukemia (AML) is caused by the arrested differentiation and dysregulated proliferation of myeloid precursors. Many AMLs harbor genetic abnormalities which determine the molecular mechanisms of the disease and are associated with distinct clinical and pathological features, prognosis, and targeted therapies. We present a case of acute myeloid leukemia with t(6;9)(p23;q34.1) and review the classic clinical presentations and underlying pathogenesis of the disease.
ABSTRACT
OBJECTIVES: Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare soft tissue tumor that, despite its characteristic marked pleomorphism, is slow growing and of intermediate grade malignancy. PHAT is not known to metastasize, but is locally aggressive with a post-excision recurrence rate of up to 50%. Two other soft tissue tumors, hemosiderotic fibrolipomatous tumor (HFLT) and myxoinflammatory fibroblastic sarcoma (MIFS), share some morphological features with PHAT, and all three have been found to possess a t(1;10) translocation. Thus, it has been suggested PHAT, HFLT, and MIFS exist within a spectrum of a single entity; however, there is only one case of PHAT with a full cytogenetic profile and this showed the t(1;10). We report a case of PHAT with a complete cytogenetic profile differing from the previously reported case. Our case demonstrates 47,XY,+7,der(7)(qter::?::q31::?::pter::?::cen::?::pter::?::q31::?::qter)x2[20]/46,XY[10] karyotype with the typical morphologic features and immunohistochemical staining pattern seen in PHAT. This suggests that PHAT may be a distinctly separate entity and not within the spectrum of HFLT and MIFS.
