Benefits of Taurisolo in Diabetic Patients with Peripheral Artery Disease.

Trimethyl-N-oxide (TMAO) has been linked to peripheral artery disease (PAD). TaurisoloⓇ is a natural, balanced phytocomplex containing resveratrol, quercetin, catechins, procianidins, gallic acid, and caffeic acid. Numerous studies have shown that TaurisoloⓇ reduces the damage of TMAO and exerts a protective effect on endothelial cells (ECs). The aim of this randomized, double-blind, single-center study was to evaluate the effects of TaurisoloⓇ on claudication in patients with PAD (Rutheford grade I, category II, Fontaine Classification: Stage IIA, American Medical Association Whole Person Impairment Classification: Class 0-WPI 0%) in two parallel groups of 31 patients. The primary outcomes were an increase in the pain-free walking distance and the ankle/brachial pressure index at the beginning and at the end of the treatment with Taurisolo. The secondary endpoint was the serum TMAO changes. The claudication distance improved by 14.1% in the Taurisolo group and by 2.0% in the placebo group, while the maximal distance increased by 15.8% and 0.6% only, respectively (both p < 0.05). The TMAO plasma levels decreased from 3.97 ± 2.13 micromole/L to 0.87 ± 0.48 (p < 0.0001) in the treated group. All these changes were highly significant both in univariate mixed models as well as in the adjusted model. Ultimately, TaurisoloⓇ might be an effective intervention to ameliorate intermittent claudication.

Flux-step method for the assessment of operational conditions in a submerged membrane bioreactor.

A flux-step method was used for monitoring the pressure variation in a solids separation membrane at different operating conditions. A submerged membrane bioreactor pilot plant, used during the short-term tests, was used to purify actual restaurant wastewater. The influence of membrane backwash and relaxation on the variation of pressure variation was also evaluated. In order to reduce the deposition of irreversible fouling, the authors modified the literature-supported filtration to backwash cycling with filtration and relaxation cycling. The trials maintained a constant filtration to relaxation ratio that was in line with optimal filtration to backwashing ratios found in the literature. The relaxation cycling between two constant flux-steps effectively counteracted membrane fouling and the excessive decrease in average pressure, and it results in a lower waste of energy and water than a backwashing strategy.