Subject(s)
Adrenergic Agents/pharmacology , Adrenergic Agents/therapeutic use , Cholinergic Agents/pharmacology , Cholinergic Agents/therapeutic use , Nose/drug effects , Paranasal Sinuses/drug effects , Paranasal Sinuses/metabolism , Animals , Drug Combinations , Female , Male , Nasal Mucosa/drug effects , Nasal Mucosa/metabolism , Rabbits , Rhinitis/drug therapyABSTRACT
Similar distortion of hypertensive response to epinephrine occurred in sarcoma-45-bearing rats, Walker carcinosarcoma-bearing rats, and hepatectomized rats. The response in the last-named was distorted on the 3rd postoperative day. The hypertensive response to epinephrine was restored after the regenerative processes in the liver were completed (7th-10th postoperative day). Distortion of the response in carcinosarcoma-bearing rats was detected beginning from the 4th day after transplantation in some of the animals and on the 14th day in the others; in all sarcoma 45-bearing rats distortion occurred by the 20th day. The pressor response was distorted usually under conditions of pharmacological block of the alpha-adrenergic receptors. It is assumed that in extensive proliferation of normal and neoplastic cells, substances exerting a selective blocking effect on the alpha-adrenoceptors of the blood vessels penetrate into circulation.
Subject(s)
Blood Pressure/drug effects , Carcinoma 256, Walker/physiopathology , Epinephrine/pharmacology , Liver/physiology , Sarcoma, Experimental/physiopathology , Animals , Female , Hepatectomy , Male , RatsABSTRACT
Sensitivity to phenylephrine, isoproterenol, serotonin, oxytocin, acetylcholine and barium chloride of vas deferens uterus und fundus strip was studied comparatively in hepatectomized and sarcoma-45, sarcoma-M1, Walker carcinosarcoma and Zajdela ascites hepatoma bearing rats. The contractile response to monoamines and oxytocin was considerably lower or absent at certain periods after hepatectomy or tumour grafting. Effects of biogenic amine antagonists were also substantially altered. The response to isoproterenol, acetylcholine and barium chloride remained unchanged. Apparently a selective alteration of a response of visceral smooth muscles mediated through alpha-adrenergic and D-serotonin receptors occurred not only during the tumour growth but also in the case of active (extensive) proliferation of the normal tissue.