ABSTRACT
BACKGROUND: We assessed the publication trends of papers on schizophrenia through an analysis of the articles published by three general psychiatric journals (Archives of General Psychiatry (AGP), the British Journal of Psychiatry (BJP), and the Australian and New Zealand Journal of Psychiatry (ANZJP) from three continents. METHOD: For each of the journals, we covered the period between 1980 and 1994. We carried out both a quantitative analysis, assessing the trends over time in the publication of papers on schizophrenia, and a qualitative analysis, classifying the articles into eight scientific fields. RESULTS: During the study period a total of 943 articles dealing with schizophrenia were published in the three journals evaluated; the proportion of papers focusing on schizophrenia was higher in the AGP and in the BJP (18 and 15%) as compared with the ANZJP (5.6%). A substantially higher proportion of basic science articles was published in the AGP as compared with the BJP and the ANZJP, whereby a somewhat larger representation of epidemiological and psychosocial research was found in the latter journals. CONCLUSIONS: Given the importance of schizophrenia in psychiatric research and practice, it will be useful to regularly monitor the research trends in this specific field.
Subject(s)
Publishing/trends , Schizophrenia , Data Collection , Humans , Journalism, Medical , ResearchSubject(s)
Environment , Parkinson Disease/etiology , Parkinson Disease/genetics , Adult , Age Factors , Aged , Case-Control Studies , Family , Female , Humans , Italy/epidemiology , Male , Middle Aged , Risk Factors , Sex Factors , SmokingABSTRACT
To clarify the role of heredity and of some environment risk factors in the etiology of idiopathic Parkinson's disease, we performed a case-control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex- and age-matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age +/- SD = 62.5 +/- 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well-water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well-water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 - 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease.
