ABSTRACT
Scrub typhus has a variety of clinical presentations ranging from asymptomatic to fever with chills, myalgias, hepatitis, gastric ulcerations and pancreatitis, all being attributed to disseminated vasculitis, with splenic infarction being a rare presentation. A 26-year man, a resident of north India, presented with an acute febrile illness and abdominal pain, computed tomography scan of the abdomen was suggestive of a splenic infarct. After ruling out other aetiology, a positive IgM (ELISA) for scrub typhus led to treatment with oral doxycycline, following which the patient was discharged symptom-free. Rarely can splenic infarction be attributable to scrub typhus; so far, five such cases have been reported in the published literature.
Subject(s)
Scrub Typhus/complications , Splenic Infarction/etiology , Adult , Doxycycline/therapeutic use , Humans , India , Male , Scrub Typhus/diagnosis , Scrub Typhus/drug therapy , Splenic Infarction/diagnosis , Splenic Infarction/drug therapy , Treatment OutcomeABSTRACT
We report here a case of disseminated Emergomyces pasteurianus infection from India in a patient with AIDS. The patient presented with weight loss, dyspnoea and multiple non-tender skin lesions over face, neck and chest over 3 months. The case was diagnosed by microscopy, histopathology of sample and isolation of fungus from skin lesion, breast nodule, bone marrow and sputum. The identification of the isolates was confirmed by sequencing internal transcribed spacer region of rDNA, beta-tubulin, actin and intein PRP8. The patient responded well to intravenous amphotericin B deoxycholate followed by itraconazole therapy.
Subject(s)
Mycoses/microbiology , Onygenales , Acquired Immunodeficiency Syndrome/microbiology , Actins/genetics , Adult , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , DNA, Intergenic/genetics , DNA, Ribosomal/genetics , Deoxycholic Acid/therapeutic use , Drug Combinations , Female , Humans , India , Inteins/genetics , Itraconazole/therapeutic use , Mycoses/diagnosis , Mycoses/genetics , Tubulin/geneticsABSTRACT
Chikungunya fever is a benign and self-limiting disease caused by an RNA virus belonging to genus alphavirus and transmitted by infected Aedes mosquitoes. However, a number of atypical presentations involving various systems have been reported. Among the neurological complications, encephalitis, myelitis, Guillain-Barre syndrome and optic neuritis are commonly seen. However, its presentation as isolated inflammatory myositis causing quadriplegia is extremely rare. We report a 35-year-old woman with quadriplegia caused by chikungunya-induced inflammatory myositis. The diagnosis was confirmed with clinical examination, electromyography study, muscle biopsy findings and exclusion of other causes. There have been case reports of inflammatory myositis in association with various infections as well as in association with other neurological presentations in chikungunya. However, this may be the first case report of isolated inflammatory myositis associated with chikungunya fever.
Subject(s)
Chikungunya Fever/complications , Myositis/virology , Adult , Chikungunya virus/isolation & purification , Female , Humans , India , Nervous System DiseasesABSTRACT
We report here the first case of disseminated Emmonsia pasteuriana infection in a patient with AIDS in India. The patient presented with weight loss, dyspnoea, left-sided chest pain and multiple non-tender skin lesions over face and body for 3 months. Disseminated emmonsiosis was diagnosed on microscopic examination and fungal culture of skin biopsy and needle aspirate of lung consolidation. It was confirmed by sequencing internal transcribed spacer region of rDNA, beta tubulin, actin, and intein PRP8. The patient responded to amphotericin B and itraconazole therapy.
Subject(s)
AIDS-Related Opportunistic Infections/diagnosis , Chrysosporium/isolation & purification , Mycoses/diagnosis , AIDS-Related Opportunistic Infections/drug therapy , AIDS-Related Opportunistic Infections/microbiology , Adult , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Biopsy, Needle , Chest Pain/microbiology , Chrysosporium/classification , Chrysosporium/genetics , DNA, Fungal/isolation & purification , DNA, Ribosomal/isolation & purification , Diagnostic Errors , Dyspnea/microbiology , Female , Humans , India/epidemiology , Itraconazole/therapeutic use , Mycoses/drug therapy , Mycoses/microbiology , Phylogeny , Weight LossABSTRACT
Dengue encephalopathy or dengue hemorrhagic fever (DHF) with neurological involvement was once considered to be one of the rarer presentations of this infectious agent. In recent years, many such clinical cases have been reported, though they still remain isolated. We hereby report a case of confirmed dengue fever with features of encephalopathy with previously unreported cranial magnetic resonance imaging findings suggestive of extensive involvement of the bilateral cerebellar region, brainstem, and thalami along with peculiar rim enhancement but normal cerebrospinal fluid analysis.
Subject(s)
Brain Diseases/pathology , Brain/pathology , Severe Dengue/complications , Adult , Brain/diagnostic imaging , Female , Humans , Magnetic Resonance Imaging , RadiographyABSTRACT
BACKGROUND: Intra-articular triamcinolone in combination with DMARDs may be able to achieve faster and tighter control of disease activity in early rheumatoid arthritis that may be the key to preventing or minimizing later deformities. OBJECTIVE: To compare the efficacy of a combination of Disease Modifying Anti-Rheumatoid Drugs (DMARDs) with Intra-articular Glucocorticoids versus only DMARDs in a group of patients with early Rheumatoid Arthritis (RA). METHODS: Fifty patients diagnosed as Rheumatoid Arthritis (RA) by American Rheumatology Association (ARA) criteria (1987) with disease duration less than two years were randomized into two groups. The Control group received a combination of Methotrexate 15 mg daily with Sulfasalazine 2 gm daily for 3 months and the Study group received the above combination along with Intra-articular injections of Triamcinolone acetate (40 mg per ml) in each of the swollen joints at the start of the study. Outcome was assessed in terms of Disease Activity Score (DAS-28), American College of Rheumatology (ACR) 20/50/70 criteria and number of rescue medications used at the end of 3 months. RESULTS: The study group had significant reductions in DAS 28 scores (3.39 versus 4.99 in control group) and significantly more subjects achieved the ACR 20/50/70 criteria at the end of 3 months (100/60/36% versus 84/20/0%) Secondary end-points like tender and swollen joint count, ESR, early morning stiffness, health assessment questionnaire (HAQ) scores and general health status were significantly reduced in the study group. Also, significantly lesser rescue medications were needed in the study group. CONCLUSION: Combination of DMARDs with Intra-articular corticosteroids is significantly better than DMARDs alone in early RA.
Subject(s)
Antirheumatic Agents/administration & dosage , Methotrexate/administration & dosage , Triamcinolone/administration & dosage , Adolescent , Adult , Drug Therapy, Combination , Female , Humans , Injections, Intra-Articular , Male , Middle Aged , Young AdultABSTRACT
Symmetrical peripheral gangrene (SPG) is an extremely rare complication of malaria that has been well described in multiple case reports of Plasmodium falciparum and mixed infection. We present a case of malaria with isolated Pl. vivax infection complicated by SPG. This index case is the first reported case of peripheral gangrene involving bilateral hands and feet in Pl. vivax infection in an adult.
