[HERNIOPLASTIC MORFOLOGICAL FEATURES (EXPERIMENTAL STADY)].

Despite many years of experience in the field of hernia surgical treatment there still exist many unsolved problems such as a safe and non infected closure of defects of abdominal cavity wall. The aim of the study was to improve the result of treatment of abdominal wall hernias with the use of new antiseptic polymer, bio-composite protective mesh membrane covered with coladerm+chlorhexidine. Experimental study involved 21 rabbits. Meshes were fixed on anterior abdominal wall according to the following schewe: Option I: mesh size 10-20mm was put into both the groin area of the rabbits. Option II: A light standart mesh grid size 10-20mm covered with coladerm was placed on both sides of abdominal wall of the rabbits. Option III: A light mesh, covered with oladerm+Chlorhexidine was placed in to the abdominal wall of the rabbits. Removal dates of taking the animals from experiments were 14th, 30th, 45th, 90th and 180th days for further histomorpological and bacteriological research. The best result from these options was when implants we covered with coladerm+Chlorhexidine, which was shown on follow up period. In third control group experessed strong connective tissue formatting stromis picture,wich is the main task of modern hernia plastic. It is expected that new bio-composite meshes, covered with coladerm+Chlorhexidine, may be succesfuly used in clinical practice, which will reduce infectious complications of meshes and problems associated with them.

[CLINICAL EVALUATION OF THE NEW ANTISEPTIC MESHES].

Improving the results of hernia treatment and prevention of complications became a goal of our research which included two parts - experimental and clinical. Histomorphological and bacteriological researches showed that the best result out of the 3 control groups was received in case of covering implant "Coladerm"+ with chlorhexidine. Based on the experiment results working process continued in clinics in order to test and introduce new "coladerm"+ chlorhexidine covered poliprophilene meshes into practice. For clinical illustration there were 60 patients introduced to the research who had hernioplasty procedures by different nets: I group - standard meshes+"coladerm"+chlorhexidine, 35 patients; II group - standard meshes +"coladerm", 15 patients; III group - standard meshes, 10 patients. Assessment of the wound and echo-control was done post-surgery on the 8th, 30th and 90th days. This clinical research based on the experimental results once again showed the best anti-microbe features of new antiseptic polymeric biocomposite meshes (standard meshes+"coladerm"+chlorhexidine); timely termination of regeneration and reparation processes without any post-surgery suppurative complications. We hope that new antiseptic polymeric biocomposite meshes presented by us will be successfully used in surgical practice of hernia treatment based on and supported by expermental-clinical research.