ABSTRACT
One new compound: 3,4-dihydro-2-(hydroxymethyl)-4-methyl-2H-pyrrol-2-ol (5) was isolated from the fruits and bark of Callistemon viminalis along with the known compounds lupeol (1), octacosanol (2), ß-sitosterol (3), betulin (4), betulinic acid (6), ursolic acid (7), corosolic acid (8), ß-sitosterol-3-O-ß-D-glucoside (9), methyl gallate (10), gallic acid (11), catechin (12), ellagic acid (13) and 3-O-acetylursolic acid (14) (compound 14 was isolated from the bark and not detected in the fruits). Structures of these compounds were elucidated on the basis of their spectroscopic data (NMR, MS, IR spectra and COSY and HR-MS for 5a). The antioxidant activity of the total extracts, petroleum ether, CH2Cl2 and EtOAc fractions together with the compounds 6, 7, 9, 10, 11, 12 and 13 was comparable with that of the standard antioxidant, ascorbic acid.
Subject(s)
Myrtaceae/chemistry , Pyrroles/chemistry , Fruit/chemistry , Molecular Structure , Plant Bark/chemistryABSTRACT
Two new compounds: 3-ß,15-α,23,28-tetrahydroxyolean-12-en-3-O-arabinopyaranoside and 3-ß,23,28-trihydroxy-olean-12-en-3-O-ß-D-glucopyranoside were isolated from the aerial parts of Ammania auriculata along with the known compounds kaempferol, ß-sitosterol-3-O-ß- D-glucoside, 2-α,3-ß,23-trihydroxyolean-12-en-28-oic acid-28-O-ß-D-glucopyranoside, quercetin, kaempferol-3-O-α-L-arabinofuranoside, kaempferol-3-O-ß-D-xylopyranoside and ellagic acid. Structures of these compounds were elucidated on the basis of their spectroscopic data (NMR, UV, MS and IR spectra). The antioxidant activities of the total extract, the fractions CH(2)Cl(2), EtOAc and the remaining aqueous together with the compounds 1, 6 and 9 were comparable with that of the standard antioxidant, ascorbic acid.
Subject(s)
Antioxidants/chemistry , Lythraceae/chemistry , Oleanolic Acid/analogs & derivatives , Flavonoids/chemistry , Magnetic Resonance Spectroscopy , Molecular Structure , Oleanolic Acid/chemistryABSTRACT
Two new compounds: 2-(3',4'-dihydroxyphenyl) ethyl-3-O-α-L-rhamnopyranosyl-4-O-p-hydroxyphenylacetyl-6-O-caffeoyl-ß-D-glucopyranoside and 2-(3',4'-dihydroxyphenyl) ethyl-3-O-α-L-rhamnopyranosyl-4-O-piperidine-3-carboxylic acid-6-O-caffeoyl-ß-D-glucopyranoside were isolated from the stem bark of Jacaranda mimosaefolia. In addition, the known compounds lupeol, betulinaldehyde, terminic acid, betulinic acid, maslinic acid, ß-sitosterol glucoside and isoacteoside were isolated and identified.
Subject(s)
Bignoniaceae/chemistry , Caffeic Acids/chemistry , Caffeic Acids/isolation & purification , Glucosides/chemistry , Glycosides/chemistry , Glycosides/isolation & purification , Hemiterpenes/chemistry , Phenols/chemistry , Plant Bark/chemistry , Glucosides/isolation & purification , Hemiterpenes/isolation & purification , Magnetic Resonance Spectroscopy , Phenols/isolation & purificationABSTRACT
OBJECTIVE: Anal fissure is a common painful condition affecting the anal canal and causes considerable morbidity and reduction in quality of life. Surgical treatment has been associated with a degree of incontinence in up to 30% of patients. This study discussed the results of clove oil 1% cream in healing of chronic anal fissure. METHOD: A single-blind randomized comparative trial was setup to compare traditional treatment with stool softeners and lignocaine cream 5% against clove oil 1% cream for 6 weeks. RESULTS: 55 patients were included in this study, 30 patients in clove oil group and 25 patients in control group. Healing had occurred in 60% of patients in clove oil group and in 12% of patients in the control group after 3-month follow up (P < 0.001). Patients in clove oil group showed significant reduction in resting anal pressure and almost all other anorectal manometric pressures compared with patients in control group. CONCLUSION: Topical application of clove oil cream demonstrated a significant beneficial effect when applied to patients suffering from chronic anal fissure.
Subject(s)
Clove Oil/therapeutic use , Fissure in Ano/drug therapy , Administration, Topical , Adult , Clove Oil/administration & dosage , Humans , Middle Aged , Phytotherapy , Single-Blind Method , Treatment OutcomeABSTRACT
The chemical investigation of the aerial parts of Haplopappus multifolius afforded the new monoterpene 2,9-epoxy-p-menth-6-en-8-ol (7, haplopappol), the new monoterpenoid ester 9-cis-p-coumaroyloxy-alpha-terpineol (8, haplofolin), the new diterpene 18-hydroxylabda-7,13Z-dien-15-oic acid (6) and its known E-isomer (5). In addition, the known dihydroflavones 3',5-dihydroxy-4',7-dimethoxydihydroflavone and 3',4',5-trihydroxy-7-methoxydihydroflavone and the known dihydroflavonols 3',5-dihydroxy-4',7-dimethoxydihydroflavonol and 3',4',5-trihydroxy-3-acetyl-7-methoxydihydroflavonol were also obtained. The structural assignments of these compounds were made possible by the different spectroscopic measurements.
Subject(s)
Asteraceae/chemistry , Flavonoids/chemistry , Terpenes/chemistry , Chile , Chromatography, Thin Layer , Flavonoids/isolation & purification , Magnetic Resonance Spectroscopy , Molecular Conformation , Plant Extracts/analysis , Spectrometry, Mass, Electrospray Ionization , Terpenes/isolation & purificationABSTRACT
Two new triglycosides, kaempferol-3-O-[(4-beta-D-apiofuranosyl)-alpha-L- rhamnopyranoside]-7-O-alpha-L-rhamnopyranoside and kaempferol-3-O-[(4-beta-D-xylopyranosyl)-alpha-L-rhamnopyranoside]-7-O- alpha-L-rhamnopyranoside were isolated from the methanol extract of Chenopodium murale, together with a known diglycoside, kaempferol-3-O-beta-D-glucopyranoside-7-O-alpha-L-rhamnopyranoside. The characterization of the three compounds was achieved by various spectroscopic methods.
