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J Neuroimmunol ; 359: 577689, 2021 10 15.
Article in English | MEDLINE | ID: mdl-34384966

ABSTRACT

Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis initially promotes memory deficits, behavioral changes, and epileptic seizures. We developed a new animal model of anti-NMDAR encephalitis using a single cerebroventricular injection of CSF from patients in adult zebrafish. We observed a reduction of the seizure threshold and recent memory deficits in those animals injected with CSF from patients with anti-NMDAR encephalitis. The locomotor activity was similar in the CSF and control groups. This zebrafish model consistently recapitulates symptoms seen in patients with anti-NMDAR encephalitis. It may provide a reliable, fast and cost-effective platform to investigate new therapeutic strategies to anti-NMDAR encephalitis.


Subject(s)
Anti-N-Methyl-D-Aspartate Receptor Encephalitis/cerebrospinal fluid , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/immunology , Cerebrospinal Fluid/immunology , Memory Disorders/immunology , Seizures/immunology , Animals , Female , Humans , Injections, Intraventricular , Locomotion/immunology , Male , Memory Disorders/prevention & control , Seizures/prevention & control , Zebrafish
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