ABSTRACT
The prophylaxis in diabetic nephropathy begin with the knowledge of factors that affect on the microalbuminuria. We designed a retrospective study with a follow-up of 8.4 +/- 2.9 years, in 75 patients with diabetes mellitus type 1: group A (n = 34) with microalbuminuria: group B (n = 41) without microalbuminuria. We tried to know the factors related to the on set of albuminuria. The mean Hb A1c was: Group A 8.7 +/- 1.5%; Group B 8.1 +/- 1% (p < 0.02). Patients that actually have microalbuminuria presented several years before a blood pressure (TA) greater than the group without microalbuminuria (Group A: TA systolic [TAS] 124.5 +/- 13 versus Group B 110.6 +/- 1 mmHg; p < 0.0001); (Group A: TA diastolic [TAD] 69.2 +/- 7 versus Group B 66.6 +/- 6 mm Hg; p < 0.0001). We confirm the influence of metabolic control on the microalbuminuria's beginning and the arterial blood pressure is greater in the group of patients with microalbuminuria actually.
Subject(s)
Albuminuria/diagnosis , Diabetes Mellitus, Type 1/urine , Adult , Albuminuria/physiopathology , Analysis of Variance , Blood Pressure , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 1/physiopathology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Prognosis , Regression Analysis , Retrospective Studies , Time FactorsABSTRACT
Treatment of idiopathic hypogonadotropic hypogonadism with an intermittent LHRH infusion pump is more physiologic than the repeated injections of gonadotropin previously used. The results of treating 7 patients, 5 males and 2 females, with this new method are presented. A better FSH and LH response to the LHRH is achieved during treatment which results in a increase in testosterone production but not so of estradiol. The size of the testicles as well as the amount of pubic hair increased in all cases, although fertility was only achieved in one patient, who also showed the best testicular response. We may conclude that treatment with intermittent infusion of LHRH is an important innovation although only partially successful since there are resistant cases and the final outcome is not better than with other methods.
