ABSTRACT
We have studied the principal chemophysical properties of cervical mucus obtained before and after diathermocoagulation (DTC) in 35 patients participating in a program for prevention of cervical carcinoma. Two months after DTC there were significant decreases in the cervical scores for both exo- and endo-cervical mucus (Moghissi scale). Twelve patients with favorable pre-DTC scores, whose condition had deteriorated 2 months subsequent to treatment, again displayed normal scores in both sites 1 year after DTC. We feel, therefore, that DTC does not cause any permanent change in the chemophysical properties of the cervical mucus, but instead only temporary deterioration during the repair phase.
Subject(s)
Cervix Mucus/analysis , Cervix Uteri/surgery , Electrocoagulation , Adult , Cervix Mucus/cytology , Cervix Mucus/metabolism , Cervix Mucus/physiology , Cervix Uteri/metabolism , Epithelium/pathology , Female , HumansABSTRACT
Between January 1982 and November 1983, 335 women at risk for endometrial carcinoma, with or without symptoms, were screened on an out-patient basis at the 3rd Department of Obstetrics and Gynecology of the University of Milan for endometrial carcinoma and its precursors. Cytologic diagnosis of material obtained with the Milan-Markley helix (Mi-Mark) was compared, in terms of acceptability and diagnostic accuracy, with histologic diagnosis of material obtained by Vabra curettage. The Mi-Mark was better accepted by the patients and there were almost no complications. Sensitivity was 93% for adenocarcinoma, 62% for atypical hyperplasia and 76% for hyperplasia without atypia. According to epidemiologic data and to our results, we suggest this screening procedure for asymptomatic obese women.
Subject(s)
Mass Screening , Uterine Neoplasms/epidemiology , Vaginal Smears , Adult , Aged , Endometrium/pathology , Female , Humans , Hyperplasia/pathology , Italy , Middle Aged , Precancerous Conditions/pathology , Risk , Uterine Neoplasms/pathologySubject(s)
Vaginitis/etiology , Adult , Bacterial Vaccines/administration & dosage , Drug Evaluation , Female , Humans , Lactobacillus acidophilus/immunology , Trichomonas Vaginitis/etiology , Trichomonas Vaginitis/microbiology , Trichomonas Vaginitis/therapy , Vaginitis/microbiology , Vaginitis/therapySubject(s)
Bacterial Vaccines/pharmacology , Lactobacillus acidophilus/immunology , Trichomonas Vaginitis/therapy , Vagina/microbiology , Antibodies, Bacterial/analysis , Female , Humans , Hydrogen-Ion Concentration , Lactobacillus/immunology , Trichomonas Vaginitis/microbiology , Vaccines, Attenuated/pharmacologyABSTRACT
Our results show in an unquestionable way that both the steroid (ethinylestradiol) and non-steroid (Ralone) estrogens studied by us were absorbed percutaneously by the rat. They also demonstrate that both estrogens affected target organs in a quite similar way being proportionally dependent upon the 1-to-1,000 ratio existing between them, as established on the basis of a known activity parameter. When one of the two estrogens is given for therapeutical purposes its systemic effects are of a dose-related type.
