ABSTRACT
Clinical and histological study of 8 cases of Vilyui encephalomyelitis (VEM), characterized by chronic and acute course has shown that all the features of local non-purulent encephalomyelitis with marked dystrophic and atrophic changes of neural tissue were characteristic of VEM. Immunomorphological reaction that manifested as perivascular and membrane lymphoplasmacytic infiltrations was observed in patients with a more acute VEM course or with exacerbation of chronic VEM. Hydrocephalus is considered as a serious aggravating factor that favours atrophic nervous changes during protracted and chronic VEM course.
Subject(s)
Brain/pathology , Encephalomyelitis/pathology , Adult , Aged , Blood Vessels/pathology , Female , Humans , Lymphocytes/pathology , Macrophages/pathology , Male , Meninges/pathology , Meningoencephalitis/diagnosis , Middle Aged , Rural Population , Siberia , Spinal Cord/pathologyABSTRACT
The main epidemiological values characterizing rubella in Moscow were calculated on the basis of a new mathematical model. Quantitative estimates of the intensity of infection in different age groups of the population were obtained. It has been established that the risk of infection in children is especially high in comparison with adult population. That is why 98% of the population aged 15 are immune. The probability of falling ill with rubella was determined for persons with different antibody levels. The cases of congenital rubella in Moscow are rare due to the low risk of infection in adults and to their immunity acquired in childhood. Consequently, there is no necessity for vaccination against rubella in Moscow at the present time, but it should be recommended to organize constant epidemiological surveillance of congenital rubella.
Subject(s)
Models, Theoretical , Rubella/epidemiology , Adolescent , Adult , Age Factors , Antibodies, Viral/analysis , Child , Child, Preschool , Female , Humans , Infant , Mathematics , Middle Aged , Moscow , Pregnancy , Pregnancy Complications, Infectious/epidemiology , Pregnancy Complications, Infectious/immunology , Rubella/congenital , Rubella/immunology , Rubella virus/immunologySubject(s)
Disease Outbreaks/epidemiology , Disease Reservoirs , Encephalitis, Tick-Borne/epidemiology , Models, Biological , Adolescent , Adult , Aged , Child , Child, Preschool , Humans , Infant , Infant, Newborn , Mathematics , Middle Aged , Risk , SiberiaABSTRACT
Viljuisk encephalomyelitis (VE) is a severe neurologic disease characterized by slow progressive dementia', oligobradykinesia, low spastic paraparesis and speech disturbances. It develops in persons of 20-50 years old. VE occurs in a small region of middle Viljui, but for last years the focus has considerably expanded. Etiology of VE is still obscure. 194 families with VE patients were examined. The data obtained contradict the hypothesis of simple recessive inheritance of VE. The value of the heredity coefficient, calculated on the basis of the Falconer - Edwards model, is 22-29% for relatives of the first relation degree. It suggests the existence of individual hereditary determined susceptibility to VE. 14 secondary cases were observed in affected families among adopted relatives (adopted children, husbands and wives of patients) with a rate exceeding random possible frequency. These observations have been evaluated as an evidence of horizontal transmission of the disease from patients with chronic forms to healthy persons. Obligatory condition for the transmission consists in a long-term contact (as a rule, more than one year). According to all known characteristics VE should be refferred to slow infections.
