ABSTRACT
A case of transient bullous dermolysis of the newborn is reported. A healthy Hispanic newborn developed bullae during the first two days of life. From age two to four weeks, the lesions healed with milia formation. There was no residual scarring or hypopigmentation. An induced blister showed dermal-epidermal separation with the PAS-positive basement membrane in the epidermal roof. PAS-positive inclusions were present in the cytoplasm of a few basal cells. Examination by electron microscopy showed degeneration of the collagen and anchoring fibrils. There were numerous stellate inclusions in the endoplasmic reticulum of the cytoplasm of the lesional basal keratinocytes.
Subject(s)
Skin Diseases, Vesiculobullous/pathology , Collagen/biosynthesis , Collagen/ultrastructure , Female , Humans , Infant, Newborn , Infant, Newborn, Diseases , Microscopy, Electron , Skin/pathology , Skin/ultrastructureSubject(s)
Adenoma, Sweat Gland/pathology , Scalp , Skin Neoplasms/pathology , Adenoma, Sweat Gland/surgery , Adult , Female , Humans , Male , Sex Factors , Skin Neoplasms/surgerySubject(s)
Forearm , Skin Neoplasms/pathology , Humans , Male , Middle Aged , Sex Factors , Skin Neoplasms/surgeryABSTRACT
A case of acanthosis nigricans coexistent with mycosis fungoides, the second report in the literature of such an association, is described.
Subject(s)
Acanthosis Nigricans/etiology , Mycosis Fungoides/complications , Skin Neoplasms/complications , Acanthosis Nigricans/drug therapy , Acanthosis Nigricans/pathology , Adult , Humans , Male , Mechlorethamine/adverse effects , Mechlorethamine/therapeutic use , Mycosis Fungoides/diagnosis , Mycosis Fungoides/drug therapy , Skin Neoplasms/drug therapy , Skin Neoplasms/pathologyABSTRACT
Scleromyxedema (Arndt-Gottron syndrome) is a rare cutaneous disease in which hyaluronic acid is deposited in the dermis. The authors describe a patient with scleromyxedema and corneal deposits. A corneal biopsy demonstrated hyaluronic acid deposition in the corneal stroma and amyloid P component in Bowman's membrane. This is the first report of scleromyxedema involving the cornea. It is also the first report of amyloid P component deposition in the cornea occurring independent of corneal amyloid deposits.
Subject(s)
Corneal Opacity/pathology , Myxedema/pathology , Adult , Biopsy , Cornea/pathology , Corneal Stroma/pathology , Humans , Hyaluronic Acid/metabolism , Male , Serum Amyloid P-Component/metabolism , Skin/pathologyABSTRACT
Woolly-hair is a congenital defect that produces a localized patch of lightly colored, curly scalp hair. Scanning electron microscopy of the abnormal hairs demonstrates twisting of the hair shaft and abnormal cuticle formation.
