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1.
Lakartidningen ; 97(37): 4008-12, 2000 Sep 13.
Article in Swedish | MEDLINE | ID: mdl-11036359

ABSTRACT

A total of 3,727 in-patients with acute abdominal symptoms were identified during the first quarter of 1995 at the surgical clinics of the nine hospitals with emergency departments in the county of Stockholm. The diagnoses were: non-specific abdominal pain 24%; cholecystitis 9%; appendicitis 8%; bowel obstruction 7%; intra-abdominal malignancy, diseases of the urinary tract and peptic ulcer 6% each; gastrointestinal hemorrhage, diverticulitis of the colon and pancreatitis 5% each; other diseases as a cause of abdominal symptoms, 19%. 1,601 operations were performed of which 47% were endoscopic procedures. The mean duration of hospital stay was 4.8 days. The length of stay increased significantly with age. The age-related relative frequency of hospitalization due to acute abdominal pain was also dramatically higher in the elderly cohorts. These facts and the prognosis of an 18% increase of inhabitants 50 years of age or older until 2010 in Greater Stockholm signal an increased need of hospital resources for this large group of patients in the coming years.


Subject(s)
Abdomen, Acute , Abdominal Pain/etiology , Emergency Service, Hospital/statistics & numerical data , Health Services Needs and Demand/statistics & numerical data , Abdomen, Acute/diagnosis , Abdomen, Acute/epidemiology , Abdomen, Acute/surgery , Adolescent , Adult , Aged , Emergency Service, Hospital/trends , Female , Health Services Needs and Demand/trends , Humans , Male , Medical Illustration , Middle Aged , Retrospective Studies , Surgery Department, Hospital/statistics & numerical data , Surgery Department, Hospital/trends , Sweden/epidemiology , Workload
2.
Cancer Immunol Immunother ; 48(8): 463-70, 1999 Nov.
Article in English | MEDLINE | ID: mdl-10550551

ABSTRACT

Granulocyte/macrophage-colony-stimulating factor (GM-CSF) has previously been indicated to enhance the therapeutic effect of the anti-colorectal carcinoma mAb17-1A as well as to augment in vivo immune effector functions. In vitro interleukin-2 (IL-2) augmented GM-CSF-induced antibody-dependent cellular cytotoxicity, a mechanism considered to be of significance for the therapeutic effect of mAb. A treatment regimen was elaborated that combined mAb17-1A (400 mg at day 3 of a 10-day treatment cycle) with the simultaneous administration of GM-CSF (250 microgram/m(2) once daily) and IL-2 (2.4 x 10(6) U/m(2) twice daily) for 10 days. The treatment cycle was repeated once a month. Twenty patients with advanced colorectal carcinoma were included in the study. One patient obtained a partial remission and 2 patients stable disease for 7 and 4 months respectively. The median survival time from the start of mAb therapy was 8 months. Owing to allergic reactions, the planned mAb17-1A dose had to be reduced by repeated infusions. At the fourth treatment cycle only 25% received the planned mAb dose. In 3 patients the GM-CSF and IL-2 dose was reduced because of side-effects. The subjective tolerability of the treatment was considered good or acceptable in more than 80% of the patients. The increment in white blood cell subsets induced by the cytokines decreased by increasing number of courses. This particular regimen did not augment the therapeutic effect of mAb17-1A anticipated from in vitro data but rather hampered the clinical effect of the antibody. The reason for this is not clear but a possibility might be the induction of immune suppression in vivo resulting from an impaired human anti-(mouse Ab) and anti-idiotypic antibody response as well as antibody-dependent cellular cytotoxicity, on the basis of a comparison of mAb17-1A/GM-CSF/IL-2- and mAb17-1A/GM-CSF-treated patients.


Subject(s)
Antibodies, Monoclonal/therapeutic use , Antigens, Neoplasm/immunology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Colorectal Neoplasms/therapy , Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use , Interleukin-2/therapeutic use , Adult , Aged , Animals , Antibodies, Monoclonal/administration & dosage , Antibodies, Monoclonal/adverse effects , Antibodies, Monoclonal, Murine-Derived , Blood Cell Count/drug effects , Calcium/blood , Colorectal Neoplasms/immunology , Female , Granulocyte-Macrophage Colony-Stimulating Factor/adverse effects , Humans , Immunotherapy , Interleukin-2/adverse effects , Male , Mice , Middle Aged , Serum Albumin/metabolism , Survival Analysis , Treatment Outcome
4.
Urology ; 50(3): 436-7, 1997 Sep.
Article in English | MEDLINE | ID: mdl-9301712

ABSTRACT

We have developed a technique that reduces the rewarm time during renal transplant vascular anastomoses by supporting the kidney in a slush-filled sterile polyurethane bag. There were no complications related to the use of this technique.


Subject(s)
Intraoperative Care/methods , Ischemia/prevention & control , Kidney Transplantation/methods , Kidney/blood supply , Polyurethanes , Cold Temperature , Hot Temperature , Humans
6.
Int J Obes ; 15(5): 327-31, 1991 May.
Article in English | MEDLINE | ID: mdl-1653187

ABSTRACT

The effects of lipolytic and antilipolytic agents on glucose transport and glycerol production in isolated human fat cells was investigated. Insulin and various adenylate cyclase inhibitors caused a dose-dependent stimulation of 3-O-methyl glucose transport. The maximum effects were 245 per cent and 100 per cent, respectively. The lipolytic agents isoprenaline, forskolin and dibutyryl cyclic AMP also caused dose-dependent stimulation of 3-O-methyl glucose transport, the maximum effect being about 100 per cent. Enprofylline counteracted the 3-O-methyl glucose transport-stimulating effect of both the lipolytic and antilipolytic agents but altered only the effect of antilipolytic agents on glycerol production. Enprofylline alone had no effect on 3-O-methyl glucose transport activity but stimulated glycerol production. It is on 3-O-methyl glucose transport activity but stimulated glycerol production. It is concluded that stimulation as well as inhibition of lipolysis at different steps in the lipolytic system is associated with acceleration of glucose transport in human fat cell which does not seem dependent upon the lipolysis rate.


Subject(s)
Adipose Tissue/drug effects , Glucose/metabolism , Adenylyl Cyclase Inhibitors , Adipose Tissue/cytology , Adipose Tissue/metabolism , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Biological Transport , Bucladesine/pharmacology , Cells, Cultured , Clonidine/pharmacology , Colforsin/pharmacology , Dinoprostone/pharmacology , Dose-Response Relationship, Drug , Drug Interactions , Humans , Insulin/pharmacology , Lipolysis , Niacin/pharmacology , Phenylisopropyladenosine/pharmacology , Xanthines/pharmacology
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