ABSTRACT
UNLABELLED: Myelotoxicity is one of the major chemotherapeutic side effects. In some adult and paediatric studies it has been shown that amifostine protects bone marrow from toxic effects of alkylating agents and platinum compounds without reduction in overall cytotoxic action. AIM OF THE STUDY: To test an efficacy of amifostine as a myeloprotectant in multiagent chemotherapy containing alkylating agents or platinum analogues. Amifostine was used in 8 children from 3 to 15 yrs of age treated with chemotherapy (CHT) for cancers. It made total number of 28 courses. Amifostine was administered every other CHT course in a dose of 750 mg/m2. The degree of myelotoxicity measured at nadir was compared between with- and without amifostine CHT courses. Anaemia, leucopenia and thrombocytopenia of WHO grades I and II were qualified as mild toxicity while grades III and IV were recognized as severe. RESULTS: Severe anaemia, leucopenia and thrombocytopenia were found after 3/14 (21%), 8/14 (57%) and 6/14 (43%) courses with amifostine. Proportion of these side effects in identical CHT courses without amifostine in the same pts. was as followed: 1/14 (7%), 7/14 (50%) and 9/14 (64%). Differences among both groups were statistically significant (p = 0.025). Mild side effects (nausea, vomiting, transient hypotension) accompanied amifostine administration in 29% of courses (4/14). CONCLUSION: Preliminary results suggest that amifostine decreased the number of severe thrombocytopenias after CHT. The drug was well tolerated by children.
Subject(s)
Amifostine/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Neoplasms/drug therapy , Adolescent , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Child , Child, Preschool , Dose-Response Relationship, Drug , HumansABSTRACT
This paper presents the case of osteogenic sarcoma, situated in fibula of 14-year-old boy. The X-ray picture of this tumor was typical of unicameral cyst, but histopathological examination showed traits of osteosarcoma. Only magnetic resonance suggested the presence of malignant neoplasm.
Subject(s)
Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Fibula/diagnostic imaging , Fibula/pathology , Osteosarcoma/diagnostic imaging , Osteosarcoma/pathology , Adolescent , Humans , Magnetic Resonance Imaging , Male , Tomography, X-Ray ComputedABSTRACT
Eleven cases of vesicouterine fistula were reported. The initial diagnosis was made when urinary incontinence was occurring. The diagnosis was best confirmed by cystoscopy and hysterography, which was positive in 9 cases. The ultrasonographic examinations allow to visualize the fistula in 5 out of 6 cases examined and to establish the diagnosis. If sonographic examination visualizes the fistula, the performing of hysterography is not necessary. The management consists of the cure of the infection of the urogenital tract and abdominal operation based on the excision of the fistula and closing of the bladder and uterus. All operated patients were cured.
Subject(s)
Cesarean Section/adverse effects , Urinary Bladder Fistula/diagnosis , Urinary Incontinence/etiology , Uterine Diseases/diagnosis , Adult , Cystoscopy , Female , Humans , Ultrasonography , Urinary Bladder Fistula/etiology , Urinary Bladder Fistula/surgery , Uterine Diseases/etiology , Uterine Diseases/surgery , Vesicovaginal FistulaABSTRACT
Because of unusual rarity of neoplastic sigmoid-vesical fistula in young patients the case of 43 years old woman, in whom the fistula was the consequence of sigmoid adenocarcinoma infiltration of urinary bladder, was presented. The patient was treated radically by resection of the sigmoid and partial resection of the urinary bladder within healthy tissue. After operation the patient was exposed to radiotherapy, after which chemotherapy followed (6 courses of 5-day chemotherapy with fluorouracil and calcium folinate). 18 months after operation, 16 months after radiotherapy and 14 after chemotherapy patient's general condition was good and control laboratory tests did not indicate the relapse of the neoplasm.
Subject(s)
Adenocarcinoma/complications , Intestinal Fistula/etiology , Sigmoid Diseases/etiology , Sigmoid Neoplasms/complications , Urinary Bladder Fistula/etiology , Adenocarcinoma/diagnosis , Adult , Female , Humans , Neoplasm Invasiveness , Sigmoid Neoplasms/diagnosisABSTRACT
Between 1984-1991 in 28 patients referred for the surgical treatment for the reason of obstruction of epididymis outlet ducts there was a suspicion of a congenital epididymis malformation put after the physical examination. The ultrasound examination of the scrotum which was performed in all cases revealed the proper view of the epididymis in 5 cases, the proper head of the epididymis with the broad tubules and the lack of the corpus and cauda in 19 cases and in 4 cases the residual head of the epididymis located in region of the upper pole of the testis. Intraoperative findings were consistent with the ultrasound results in 75.0% of cases. The highest consistency between the ultrasonographic and intraoperative findings was found in the cases with the proper view of the head of the epididymis with agenesis of corpus and cauda. In 32.1% of cases malformations of epididymis and vas deferens were associated with the malformations of the urinary tract.
