1.
Mol Divers
; 24(3): 707-716, 2020 Aug.
Article
in English
| MEDLINE
| ID: mdl-31363886
ABSTRACT
A simple method for the synthesis of functionalized 2H-pyrans via a catalytic reaction of an oxirane, an alkyne, and a malonate has been developed in which a 6-exo-dig cyclization pathway is observed. In this transformation, the attack of in situ generated copper acetylides on oxiranes formed homopropargylic alcohol intermediates which further transferred to 2H-pyrans with the help of malonates.