ABSTRACT
Adult laryngeal hemangiomas are uncommon and often poorly symptomatic. The authors describe a laryngeal hemangioma with acute airway obstruction and radiologic findings suggesting a chondrosarcoma-like neoplasm, while pathologic features were consistent with an ossified hemangioma. The presence of fields of bone metaplasia into a classical cavernous hemangioma is an unusual phenomenon which, to our knowledge, was never previously described in the larynx. Difficulties concerning the differential diagnosis and modality of treatment are also discussed.
Subject(s)
Hemangioma/diagnostic imaging , Laryngeal Neoplasms/diagnostic imaging , Airway Obstruction/etiology , Bone Neoplasms/diagnosis , Diagnosis, Differential , Hemangioma/pathology , Hemangioma/surgery , Humans , Laryngeal Neoplasms/pathology , Laryngeal Neoplasms/surgery , Larynx/pathology , Magnetic Resonance Imaging , Male , Metaplasia/diagnosis , Middle Aged , Thyroidectomy , Tomography, X-Ray ComputedABSTRACT
Skull base metastases are extremely rare. The authors report a case of a 65-year-old man who presented with a headache and diplopia secondary to a skull base metastasis from occult renal cell carcinoma. Since there were no other systemic metastases, radical nephrectomy and radiotherapy of the unresectable skull base location were performed. He subsequently received immunotherapy with sunitinib, everolimus, and sorafenib with local and systemic control of the disease after 53 months from surgery. When metastasis is unresectable radical nephrectomy and radiotherapy aimed at the metastasis may be of benefit improving quality of life. Immunotherapy may provide alternative treatment strategies improving the outcomes of patients affected by this rare pathology with historically poor prognosis.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Renal Cell/secondary , Kidney Neoplasms/pathology , Neoplasms, Unknown Primary/therapy , Skull Base Neoplasms/secondary , Aged , Carcinoma, Renal Cell/therapy , Combined Modality Therapy , Everolimus/administration & dosage , Humans , Immunotherapy , Indoles/administration & dosage , Male , Nephrectomy , Niacinamide/administration & dosage , Niacinamide/analogs & derivatives , Phenylurea Compounds/administration & dosage , Pyrroles/administration & dosage , Skull Base Neoplasms/therapy , Sorafenib , SunitinibABSTRACT
The present study reports a case of percutaneous sclerotherapy of a giant cystic cervicomediastinal lymphangioma using OK-432. To the best of our knowledge, percutaneous sclerotherapy of a mediastinal lymphangioma using OK 432 has not previously been reported in the English literature.
Subject(s)
Antineoplastic Agents/administration & dosage , Head and Neck Neoplasms/therapy , Lymphangioma/therapy , Mediastinal Neoplasms/therapy , Picibanil/administration & dosage , Sclerosing Solutions/administration & dosage , Sclerotherapy/methods , Adult , Female , Humans , Magnetic Resonance Imaging , Remission InductionABSTRACT
Eyelids emphysema is a rare condition due to air trapping in subcutaneous tissue of the orbit. It has been clinically and radiologically documented, but histologic evaluation has not been noted. We report a case of a middle-aged woman with periorbital swelling due to self-induced Valsalva maneuver, persisting after decompressive therapy. A fine-needle biopsy was performed and showed a mixed population of osteoclastic-like giant cells and mononuclear epithelioid cells, which were suspected of pathological proliferative disease. Specimens from blepharoplasty indicated pseudocystic empty spaces surrounded by epithelioid cells and giant cell granulomas. Immunohistochemical stains favored diagnosis of benign granulomatous disease, such as subcutis cystic pneumatosis. Histologic examination represented an important tool for differential diagnosis with soft tissue neoplasms of the orbit in subcutis emphysema with unusual clinical presentation and abnormal course.
Subject(s)
Eyelid Diseases/pathology , Orbital Neoplasms/pathology , Subcutaneous Emphysema/pathology , Diagnosis, Differential , Female , Granuloma/pathology , Humans , Middle AgedABSTRACT
Internal carotid artery pseudoaneurysm is a rare but potentially lethal complication of sinus surgery. We present 2 cases of delayed carotid pseudoaneurysm development after internal carotid laceration during functional sinus surgery for chronic sinusitis to emphasize the need to follow up the patients with profuse bleeding perioperatively and to identify when to suspect iatrogenic vascular malformations.
