[Comparison of determination methods and application of a computer program using a screening coordinate system to interpret hemoglobin A1c in patients with diabetes types 1 and 2]. / Sravnenie metodov opredeleniia i primenenie vychislitel'noi programmy s ispol'zovaniem ékrannoi sistemy koordinat dlia interpretatsii gemoglobina A1c u bol'nykh sakharnym diabetom tipov 1 u 2.

The aim of the work is to compare methods of hemoglobin A1c determination in ratio with basic metabolism indices using computer program with graphic interpretation of results in patients with diabetes of 1 and 2 types. It was found out that more specific hemoglobin determination by isoelectrofocusing method more completely reflects the state of carbohydrate metabolism in diabetic patients. The importance of hemoglobin A1c determination in case of 2 type diabetes is particularly emphasized.

[Evaluation of colorimetric method for analysis of glycated hemoglobin]. / Analiz kolorimetricheskogo metoda opredeleniia glikirovannogo gemoglobina.

The level of glycated hemoglobin (GH) measured by the Diabetic test colorimetric method did not depend on the compensation. On the other hand, its level was increased in diabetes mellitus decompensation in comparison with subcompensation, if isoelectrofocussing of the studies hemolysates was carried out prior to colorimetry. Study of colorimetric migration of hemolysates showed that they were represented by a background which could distort the results.

[Level of hemoglobin A1c and modified blood serum albumin in patients with diabetes mellitus]. / Soderzhanie gemoglobina A1c i modifitsirovannogo al'bumina syvorotki krovi u bol'nykh sakharnym diabetom.

Hemoglobin A1c was studied by means of isoelectric focusing in borate-polyol system and modified albumin--using electrophoresis of blood serum on acetate-cellulose films with subsequent TCA-ethanol sedimentation in healthy volunteers and patients with diabetes mellitus. These parameters were increased in the patients, whereas content of the albumin was decreased and the content of hemoglobin A1c was altered only slightly during treatment of diabetes. Content of hemoglobin A1c and modified albumin was shown to depend on the compensation state of diabetes mellitus.