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Mol Biol (Mosk) ; 36(4): 605-9, 2002.
Article in Russian | MEDLINE | ID: mdl-12173462

ABSTRACT

A model of the simplest epigene was constructed to have two alternative states, which proved to be stable and transmittable through Escherichia coli cell generations. A switch from one to another state was induced by thermal and chemical external signals. The results gave further insight into the dynamic mechanism of preservation, coding, and transmission of the genetic information.


Subject(s)
Bacterial Proteins/genetics , DNA-Binding Proteins , Escherichia coli Proteins , Escherichia coli/genetics , Genetic Engineering/methods , Repressor Proteins/genetics , Bacterial Proteins/metabolism , Escherichia coli/drug effects , Escherichia coli/metabolism , Gene Expression Regulation, Bacterial/drug effects , Isopropyl Thiogalactoside/pharmacology , Lac Repressors , Plasmids/genetics , Promoter Regions, Genetic , Repressor Proteins/metabolism , Temperature , Viral Proteins , Viral Regulatory and Accessory Proteins , beta-Galactosidase/genetics , beta-Galactosidase/metabolism
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