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Experimental osteoporosis and its correction.
Petrakov, A V; Yarygin, V N; Lychkov, A E; Golubev, Yu Yu; Puzikov, A M; Golubeva, G Yu; Melent'ev, A S.
Bull Exp Biol Med ; 157(1): 99-102, 2014 May.
Article in English | MEDLINE | ID: mdl-24915948

ABSTRACT

Osteoporosis was modeled in rats by chronic (6 months) treatment with omeprazole or serotonin, and bone tissue status was studied in experimental hepatic fibrosis and during serotonin treatment under conditions of hepatic fibrosis. Serum levels of calcium, phosphorus, alkaline phosphatase, albumins, and creatinine and bone tissue levels of calcium, phosphorus, magnesium, and iron were measured. Treatment with mesenchymal stem cells over 6 months reduced the severity of osteoporosis.


Subject(s)
Liver Cirrhosis/therapy , Mesenchymal Stem Cell Transplantation , Osteoporosis/therapy , Serotonin/pharmacology , Albumins/metabolism , Alkaline Phosphatase/blood , Animals , Bone Density/drug effects , Bone and Bones/metabolism , Bone and Bones/pathology , Calcium/blood , Carbon Tetrachloride , Creatinine/blood , Female , Iron/metabolism , Liver Cirrhosis/chemically induced , Liver Cirrhosis/metabolism , Liver Cirrhosis/pathology , Magnesium/blood , Omeprazole , Osteoporosis/chemically induced , Osteoporosis/metabolism , Osteoporosis/pathology , Phosphorus/blood , Rats , Rats, Wistar
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