ABSTRACT
The aim of the study was to investigate the dynamics of arterial stiffness and endothelial function parameters under the influence of perindopril arginine and indapamide fixed combination in arterial hypertension (AH) patients. 30 persons with 1-3 degree AH were included into the study. The treatment duration was 24 weeks. Central aortic blood pressure (BP), augmentation pressure and index (AIx), carotid-femoral and carotid-radial pulse wave velocity (PWV), brachial artery endothelium-dependent vasodilatation (EDVD), office and ambulatory BP as well as orthostatic BP falls were evaluated under the influence of selected therapy. 27 patients completed the study protocol. Results showed that aortic systolic BP was significantly reduced by 10.7 mmHg, augmentation pressure - by 3.6 mmHg and AIx - by 6.5%. Carotid-radial PWV decreased by 0.8 m/s. Carotid-femoral PWV did not change. We also revealed the EDVD increase by week 12. The EDVD growth was correlated with degree of aortic systolic BP reduction (r=-0.48, p=0.02). Office and ambulatory BP declined by 15.8/10.0 and 10.0/7.5 mmHg respectively. The target BP <140/90 mmHg was achieved in 20 (74.1%) persons. At the same time the orthostatic hypotension did not rise. Conclusion. We concluded that perindopril arginine/indapamide fixed combination improved vascular function in hypertensive patients by wave reflection reduction, peripheral arterial stiffness lowering and endothelial function improvement.
Subject(s)
Blood Pressure/drug effects , Endothelium, Vascular , Hypertension , Indapamide , Perindopril , Vascular Resistance/drug effects , Administration, Oral , Antihypertensive Agents/administration & dosage , Antihypertensive Agents/adverse effects , Antihypertensive Agents/pharmacokinetics , Arteries/drug effects , Arteries/physiopathology , Biological Availability , Drug Combinations , Drug Synergism , Endothelium, Vascular/drug effects , Endothelium, Vascular/physiopathology , Female , Humans , Hypertension/drug therapy , Hypertension/physiopathology , Indapamide/administration & dosage , Indapamide/adverse effects , Indapamide/pharmacokinetics , Male , Middle Aged , Perindopril/administration & dosage , Perindopril/adverse effects , Perindopril/pharmacokinetics , Pulse Wave Analysis/methods , Treatment Outcome , Vasodilation/drug effectsABSTRACT
The endocardial manipulations and bolus intracoronary administration of contrast substances, of the first generation in particular, can induce disturbances of the myocardium repolarization and different disturbances of the cardiac rhythm, life-threatening included. The aim of the investigation is to assess transitory electrophysiological alterations in the myocardium during coronarography and during the first day after it. Under examination there were 39 patients with ischemic heart disease and stenocardia of the II-III functional classes in whom the coronarography was performed according to clinical indications. The Holtner dynamic observation of ECG was made in all the patients. All the ECG changes were detected and estimated during coronarography: arrhythmias, disturbances of conduction and transitory ischemic alterations of the myocardium. It gives a possibility to decide between the methods of pharmacological correction of possible disturbances.
Subject(s)
Coronary Angiography , Electrocardiography , Aged , Angina Pectoris/diagnosis , Angina Pectoris/physiopathology , Arrhythmias, Cardiac/diagnosis , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/physiopathology , Coronary Angiography/adverse effects , Coronary Angiography/methods , Coronary Disease/diagnosis , Coronary Disease/physiopathology , Electrocardiography, Ambulatory , Female , Humans , Male , Middle Aged , Time FactorsABSTRACT
The auditory evoked potentials (AEP) were recorded in 10 healthy subjects under the conditions of simple rhythmic stimulation and in an attention task. The mid- (10-60 msec) and long-latency (up to 400 msec) AEP were analyzed by mapping the evoked potentials and by assessment of their spatial-temporal characteristics. It is hypothesized that the interaction of the parietal and left-sided temporal and frontal divisions exert an efferent influence on the brainstem structures in the 15-35 msec time segment. The amplitude of the P90 and P250 waves is reduced in the attention task. The amplitude of the late component P350 increases mainly in the central and anterior divisions of the brain.
Subject(s)
Attention/physiology , Brain/physiology , Evoked Potentials, Auditory/physiology , Acoustic Stimulation , Adult , Afferent Pathways/physiology , Brain Mapping , Brain Stem/physiology , Cerebral Cortex/physiology , Efferent Pathways/physiology , Humans , Male , Sound Localization/physiology , Thalamus/physiologyABSTRACT
125I-labelled fibrinogen kinetics has been studied in 73 patients with rheumatoid arthritis (RA). Of them, 53 subjects underwent hemosorptions or hemosorptions combined with plasmapheresis. Fibrinogen metabolism in RA patients appeared enhanced versus healthy controls. It was observed that hemosorption treatment or its combination with plasmapheresis produce positive changes in clinical and laboratory RA parameters, improve fibrinogen metabolism. The study of fibrinogen kinetics is useful in assessing efficacy of on-going treatment.
Subject(s)
Arthritis, Rheumatoid/blood , Arthritis, Rheumatoid/therapy , Fibrinogen/metabolism , Hemoperfusion , Plasmapheresis , Adult , Combined Modality Therapy , Female , Hemoperfusion/methods , Humans , Iodine Radioisotopes , Kinetics , Male , Middle Aged , Plasmapheresis/methods , Time FactorsABSTRACT
Auditory evoked potentials (AEPs) were recorded in 10 adult healthy subjects under conditions of simple rhythmical stimulation and during solving selective attention task. Middle- (10-60 ms) and long-latency (up to 400 ms) AEPs were analysed by AEP mapping and by evaluation of their spatio-temporal characteristics. it is suggested that interaction between the parietal, left temporal and left frontal cortical areas exerts efferent influence to brainstem structures over a period of 15-35 ms. Amplitudes of P90 and P250 components were reduced during selective attention task. The late P350 component increases, mainly, in the central and frontal cortical areas.
