[Work capacity status after acute craniocerebral trauma]. / Sostoianie trudosposobnosti posle ostroi cherepno-mozgovoi travmy.

The working capacity of 1,855 patients after craniocerebral trauma (CCT) was analysed. A unified approach to the diagnosis of the type and severity of the CCT in all stages of the follow-up and to active complex treatment was recorded. The chances of restoration of working capacity are higher in young individuals, males, those engaged in intellectual work, and in persons with trauma suffered in everyday life. The possibility of disability is high in persons of prepension age, females, persons engaged in qualified physical work, and in trauma suffered at work. Medical factors, the severity of the trauma and reversibility of the deficiency signs have a more marked and significant effect on the condition of the working capacity at the outcome of CCT.

[Cyclic analogs of bradykinin, containing a carboxyl group]. / Tsiklicheskie analogi bradikinina, soderzhashchie karboksil'nuiu gruppu.

1 alpha-beta-carboxypropionyl-cyclo(9----1 epsilon)-[Lys1, Gly6]bradykinin (Suc-c[Lys1, Gly6]B), 1 alpha-beta-carboxypropionyl-cyclo(10----1 epsilon)kallidin (Suc-cK), cyclo(10 gamma----1 epsilon)-[Glu10]kallidin (c[Glu10]K) and cyclo(11 gamma----1 epsilon)kallidylglutamic acid (cKG) were synthesized. Suc-c[Lys1, Gly6]B and Suc-cK were prepared by acylating the appropriate cyclopeptides with succinic anhydride. c[Glu10]K and cKG were obtained by the classic peptide synthesis, the cyclization being carried out with 61 and 42% yields, respectively. The protecting groups were then eliminated by catalytic hydrogenation. c[Glu10]K and cKG exerted myotropic action on isolated rat uterus (alpha 0.73 and 0.89, pD2 6.61 and 8.61, respectively). cKG displayed direct myotropic activity with respect to electrically stimulated rat vas deferens and guinea-pig ileum, potentiating the contractions (by 100%) in response to electric stimuli. c[Glu10]K and cKG elicit histamine release in isolated rat mast cells (EC30 4.91.10(-5) and 1.47.10(-6) M, respectively). Both cyclopeptides alter arterial pressure following intravenous administration to anaesthetized rats, cats and dogs and affect heart rate. In all assays cKG is more active than c[Glu10]K. Suc-c[Lys1, Gly6]B and Suc-cK do not possess myotropic, histamine-releasing or hypotensive activity, though they were found to elicit a transient increase of bloodflow in cats and dogs.

[Various aspects of the pathogenesis, clinical picture and treatment of migraine]. / Nekotorye aspekty patogeneza, kliniki i lecheniia migreni.

In a series of 108 patients with migraine the authors studied the characteristics of the emotional-personality sphere and autonomic nervous system, as well as the status of the brain nonspecific systems. The findings of nocturnal electropolygraphy were also used in the study. The efficacy of drugs with antiserotonin action versus multiple modality therapy was compared. The observed disorders in the psychic, autonomic and endocrine systems are interpreted as a consequence of dysfunction of the central integrative cerebral apparatuses. The most effective approaches toward the multiple modality therapy of migraine patients have been developed.

[Mechanism of action of cyclokinins]. / O mekhanizme deistviia tsiklokininov.

Cyclic analogs of bradykinin (CBK) and kallidin (CK) have a weak myotropic activity and a marked and prolonged hypotensive effect unlike linear bradykinin (BK) and kallidin (K) which produce a short-term hypotension and considerable contraction of rat uterus smooth muscles. Myotropic effects of BK and CK were significantly inhibited by phentolamine, methysergide, papaverine and verapamil. Atropine, diphenhydramine and propranolol have no influence on the kinin-induced myotropic responses. The prolonged decrease in blood pressure induced by CBK and CK is observed in un- and anesthetized normotensive, spontaneously hypertensive rats and rats with renovascular hypertension and is absent from anesthetized cats and guinea-pigs. This indicates the species specificity of cyclokinins. Indomethacin, diphenhydramine and methysergide failed to influence the BK- and CK-induced hypotensive effects on anesthetized rats. CaCl2 did not influence the magnitude of the hypotensive effect of BK and CK, however, it significantly shortened the duration of the CK-induced hypotensive effect. In vitro CBK and CK inhibited activity of kininase II in a similar manner (at a concentration range of 10(-5) M) but to a less extent than BK (10(-7)-10(-6) M). It is suggested that the hypotensive effect of CK is mediated at least partly via Ca2+-dependent systems and inhibition of kininase II.