[Clinical trial of the effects of isodibut on several indicators of microcirculation in combined therapy of patients with diabetes mellitus]. / Klinicheskaia otsenka vliianiia izodibuta na nekotorye pokazateli mikrotsirkuliatsii v kompleksnom terapii bol'nykh sakharnym diabetom.

The authors have tried a new drug isodibut, aldoreductase inhibitor, of Russian produce in 53 patients with diabetes mellitus. A course of isodibut++ has improved blood coagulation and fibrinolysis, microcirculatory blood flow, normalized muscular blood flow as indicated by electrocoagulation, conjunctival biomicroscopy, radionuclide tracing. The drug is recommended for treatment and prevention of diabetic angiopathy.

[Diagnostic value of studying the indicators of blood lipid composition and the status of intravascular microcirculation in patients with diabetes mellitus associated with ischemic heart disease]. / Diagnosticheskaia zhachimost' issledovaniia pokazatelei lipidnogo sostava krovi i sostoianiia vnutrisosudistoi mikrotsirkuliastii u bol'nykh sakharnym diabetom v sochetanii s ischemicheskoi bolezn'iu serdtsa.

A comprehensive study of blood lipid composition and microcirculatory indices was performed in 88 patients with diabetes mellitus (DM) combined with coronary heart disease (CHD). A "syndrome" of mutual aggravation was shown to develop in the combination of DM and CHD. As a result of it the above indices were changed depending on clinical signs of each of the two diseases. Lipid metabolic and microcirculatory derangements depended mostly on a degree of compensation of carbohydrate metabolism. a DM type, the presence of diabetic angiopathies and CHD gravity.

[Use of glipizide and evaluation of its effect on microcirculation in patients with diabetes mellitus type 2]. / Primenenie glipizida i otsenka ego vliianiia na mikrotsirkuliatsiiu u bol'nykh sakharnym diabetom II tipa.

The paper is concerned with the assessment of glipizide action in 32 patients aged 34 to 68 suffering from diabetes mellitus with decompensation of metabolic processes. Good tolerance of the drug, its positive hypoglycemic action enhanced by its combined use with acetylsalicylic acid were noted. No convincing proofs of glipizide influence on microcirculatory indices were obtained. In comparing its hemorheological action with other sulfanilurea drugs of the 2nd generation a similar effect of glipizide with manilin as monotherapy was revealed, on the one hand, and, on the other hand, similar action of glipizide with acetylsalicylic acid and diamicron was noted.

[Hemostasis and microcirculation in patients with diabetic ketosis]. / Gemostaz i mikrotsirkuliatsiia u bol'nykh s diabeticheskim ketoatsidozom.

Indices of acid-base equilibrium (ABE), the level of ketone bodies, coagulation and platelet procoagulant hemostasis, and erythrocyte aggregation were studied in 102 patients with diabetes mellitus, of them in 58 patients with diabetic ketoacidosis and in 10 practically healthy persons. The most frequent cause of the development of diabetic ketoacidosis was poorly controlled treatment of diabetes and infections. The most frequent type of ABE disorder in patients with diabetic ketoacidosis was metabolic acidosis with secondary compensatory respiratory alkalosis. Ketoacidosis was characterized by hemostatic disorders after hypercoagulation type, an increase in platelet and erythrocyte aggregation activity with secondary activated fibrinolysis.

[Hormonal status of diabetes mellitus patients with microcirculation disorders]. / Gormonal'nyi status u bol'nykh sakharnym diabetom s narusheniiami mikrotsirkuliatsii.

The results of the study of immunoreactive insulin (IRI) and anti-insular hormones show their correlation with hemorheological disorders in patients with diabetic angiopathies. The results obtained indicate a possible involvement of the anti-insular hormones in the development of vascular changes in diabetes mellitus.