Subject(s)
Ectromelia, Infectious/epidemiology , Mice, Inbred Strains , Poxviridae Infections/epidemiology , Poxviridae Infections/veterinary , Rodent Diseases/epidemiology , Animals , Ectromelia, Infectious/diagnosis , Ectromelia, Infectious/transmission , Female , Housing, Animal , Male , Mice , National Institutes of Health (U.S.) , Rodent Diseases/diagnosis , Rodent Diseases/transmission , United StatesABSTRACT
The oral contraceptive combination of ethynodiol diacetate with ethinyl estradiol (Demulen) was given cyclically to 48 female rhesus monkeys for 5 years. Doses employed were 1, 10, and 50 times the human dose. Treatment did not induce palpable breast nodules, and there were no deaths from mammary gland cancer.
Subject(s)
Ethinyl Estradiol/adverse effects , Ethynodiol Diacetate/adverse effects , Mammary Glands, Animal/drug effects , Mammary Neoplasms, Experimental/chemically induced , Animals , Drug Interactions , Ethinyl Estradiol/administration & dosage , Ethynodiol Diacetate/administration & dosage , Female , Haplorhini , Macaca mulatta , Mammary Glands, Animal/metabolism , Time FactorsABSTRACT
Oral contraceptives were administered cyclically to 96 female rhesus monkeys for 5 years. Forty-eight animals received Enovid-E and 48 were treated with Ovulen at doses 1, 10, and 50 times the human dose. Ophthalmic lesions did not occur at any of the dose levels employed. Significant fundic lesions, including papilledema, venous dilatation, venous retinal thrombosis, or arterial retinal thrombosis, did not develop in any of the treated animals.
