ABSTRACT
BACKGROUND: This study aims to investigate radiological and clinical factors which predict malignancy in indeterminate pulmonary nodules in patients with head and neck cancer (HNC). METHODS: Prospective data were collected in 424 patients who were reviewed in the NHS Lothian HNC multidisciplinary meeting from May 2016 to May 2018. Staging and follow-up CT chest imaging were reviewed to identify and assess pulmonary nodules in all patients. RESULTS: About 61.8% of patients had at least one pulmonary nodule at staging CT. In total, 25 patients developed malignancy in the chest. Metastatic disease in the chest was significantly associated with unknown or negative p16 status (p < .0005). Pleural indentation and spiculation were associated with indeterminate nodules, subsequently being shown to represent metastatic disease (p > .0005 and p = .046, respectively). CONCLUSION: Negative or unknown p16 status was associated with an increased propensity to develop metastatic disease in the chest in patients with HNC.
Subject(s)
Head and Neck Neoplasms/diagnostic imaging , Lung Neoplasms/epidemiology , Multiple Pulmonary Nodules/epidemiology , Head and Neck Neoplasms/pathology , Humans , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/pathology , Lung Neoplasms/secondary , Multiple Pulmonary Nodules/pathology , Multiple Pulmonary Nodules/secondary , Neoplasm Staging , Prospective Studies , Radiography, Thoracic , Risk FactorsABSTRACT
A 38-year-old male patient presented to the ear, nose and throat department with shortness of breath over last 2 months. The CT scan of the neck and chest revealed a 3.3×3 cm tumour behind the right thyroid lobe extending into the tracheo-oesophageal (TO) groove with tracheal compression. The ultrasound scan of the neck and targeted fine needle aspiration followed by core biopsy raised a suspicion of Hodgkin's lymphoma. The patient underwent a right hemithyroidectomy and incisional biopsy of the right TO groove tumour. The histology confirmed a Hasenclever's three nodular sclerosing Hodgkin's lymphoma for which he received adjuvant chemotherapy. An incidental pT1a pN0 thyroid papillary microcarcinoma in the adjacent thyroid parenchyma was completely excised. This represents a case of TO Hodgkin's lymphoma, of which there are no current published case reports. We aim to raise awareness about this rare condition by sharing the diagnostic work up and successful management in a multidisciplinary team setting.
Subject(s)
Carcinoma, Papillary/diagnosis , Esophageal Neoplasms/diagnosis , Hodgkin Disease/diagnosis , Neoplasms, Multiple Primary/diagnosis , Respiratory Sounds , Thyroid Neoplasms/diagnosis , Tracheal Neoplasms/diagnosis , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy, Large-Core Needle , Carcinoma, Papillary/complications , Carcinoma, Papillary/pathology , Carcinoma, Papillary/therapy , Chemotherapy, Adjuvant , Diagnosis, Differential , Dyspnea/etiology , Endoscopic Ultrasound-Guided Fine Needle Aspiration , Esophageal Neoplasms/complications , Esophageal Neoplasms/pathology , Esophageal Neoplasms/therapy , Esophagus/diagnostic imaging , Esophagus/pathology , Esophagus/surgery , Hodgkin Disease/complications , Hodgkin Disease/pathology , Hodgkin Disease/therapy , Humans , Incidental Findings , Male , Neck Dissection , Neoplasms, Multiple Primary/complications , Neoplasms, Multiple Primary/pathology , Neoplasms, Multiple Primary/therapy , Thyroid Neoplasms/complications , Thyroid Neoplasms/pathology , Thyroid Neoplasms/therapy , Thyroidectomy , Tomography, X-Ray Computed , Tracheal Neoplasms/complications , Tracheal Neoplasms/pathology , Tracheal Neoplasms/surgery , Treatment Outcome , UltrasonographyABSTRACT
INTRODUCTION: Allergic rhinitis (AR) is a common inflammatory condition of the nasal mucosa affecting approximately 20% of the population worldwide. Current therapies include intranasal antihistamines, corticosteroids, subcutaneous and sublingual immunotherapy (SLIT). This review and meta-analysis assess the efficacy of SLIT in the management of grass pollen-induced AR in adults. METHODS: Ovid EMBASE, Ovid EBM Reviews, Cochrane Central Register of Controlled Trials, Ovid MedLine and PubMed were searched using the following terms: 'sublingual immunotherapy', 'SLIT', 'rhinitis', 'allergic rhinitis', 'rhinosinusitis' and 'rhino-conjunctivitis'. All included studies were double-blind, placebo-controlled and randomised trials. Primary outcome was symptom score and secondary outcome included quality of life and safety profile. Meta-analysis of symptom improvement was carried out. RESULTS: Six studies were identified with 979 subjects randomly allocated to SLIT and 992 to a placebo control. All studies reported an improvement in symptoms with SLIT, with five reaching statistical significance (P < .05). Four studies reported statistically significant improvement in quality of life (P < .05). Oral pruritus was the most common adverse event reported. The overall risk of bias was high in 50% of the studies. CONCLUSIONS: Sublingual immunotherapy was a safe and effective treatment for grass pollen-induced AR in adults, and therefore, consideration should be given to its use for moderate-to-severe disease in the UK-wide population.
Subject(s)
Rhinitis, Allergic/therapy , Sublingual Immunotherapy , Adolescent , Adult , Aged , Allergens , Humans , Middle Aged , Pollen , Rhinitis, Allergic/diagnosis , Rhinitis, Allergic/etiology , Young AdultABSTRACT
OBJECTIVE: PerClot® is a biocompatible, polysaccharide haemostatic system recommended for surgical procedures. It is an absorbable modified polymer that is non-pyrogenic and is derived from purified plant starch. Our goal was to evaluate the safety, efficacy and usefulness of PerClot® in head and neck surgery (H&N) in our department. METHODS: All patients who received PerClot® after their neck operation over 1-year period (2019-2020) were prospectively investigated. The information collected included demographics, admission and discharge dates, type of operation, operative details, postoperative complications and their management. The data were collected and analysed using Excel. RESULTS: A total of 57 patients (males = 26, females = 31) with mean age of 51 (range 19-83) were identified. None of the patients developed primary or secondary haemorrhage. Ten patients suffered from post-operative wound complications (18%). Wound infection was noticed in 9/57 (16%) of patients. 1/57 patients had seroma. CONCLUSIONS: PerClot® is safe, effective in reducing the postoperative bleeding and would appear to be useful in head and neck surgery with minimal adverse effects.
