"I don't know who you are": anomia for people's names in Alzheimer's disease.

It is well known that difficulty in the retrieval of people's names is an early symptom of Alzheimer's Disease Dementia (ADD), but there is a controversy about the nature of this deficit. In this study, we analyzed whether the nature of the difficulty in retrieving proper names in ADD reflects pre-semantic, semantic, or post-semantic difficulties. To do so, 85 older adults, 35 with ADD and 50 cognitively healthy (CH), completed a task with famous faces involving: recognition, naming, semantic questions, and naming with phonological cues. The ADD group scored lower than the CH group in all tasks. Both groups showed a greater capacity for recognition than naming, but this difference was more pronounced in the ADD group. Additionally, the ADD group showed significantly fewer semantic errors than the CH group. Overall results suggest that the difficulties people with ADD have in naming reflect a degradation at semantic level.

Efficacy of supervised exercise on sleep of women who survived breast cancer: a systematic review with meta-analysis.

PURPOSE: To analyze the efficacy of supervised exercise (SE) compared with control protocols on sleep parameters of women who survived breast cancer. METHODS: This systematic review with meta-analysis searched studies using the following electronic databases: PubMed, Scopus, Physiotherapy Evidence Database (PEDro), Cochrane Library, and EMBASE. The PEDro scale assessed the bias risk, and the study protocol was registered in the PROSPERO (no. CRD42023420894). RESULTS: Of 3,566 identified studies, 13 randomized clinical trials involving 847 women diagnosed with breast cancer were included. Interventions consisted of SE in an outpatient setting (62%) or combined protocols with supervised and home exercises. Most interventions (85%) used multicomponent protocols with aerobic and resistance exercises. Usual care and health education were the most reported controls. SE decreased the sleep disturbance score (- 31.61 [95% confidence interval = - 39.40 to - 23.83]) of the European Organisation for Research and Treatment of Cancer quality of life questionnaire and daytime dysfunction score (- 0.41 [95% confidence interval = - 0.73 to - 0.09]) of the Pittsburgh Sleep Quality Index (PSQI). Also, SE presented a tendency to improve the self-reported sleep quality score of the PSQI (p = 0.06). CONCLUSION: SE increased the subjective sleep quality and immobility time and decreased sleep disturbance and daytime dysfunction symptoms in women who survived breast cancer. Most SE protocols were multicomponent, with aerobic and resistance exercises ranging from moderate to high intensity. IMPLICATIONS FOR CANCER SURVIVORS: Supervised exercise may improve sleep quality and reduce symptoms of sleep disorders, contributing to survival outcomes.

Irrigation level and substrate type on the acclimatization and development of mandacaru (Cereus jamacaru DC.): an emblematic cactus from Brazilian semiarid region.

Mandacaru is a cactus with great socioeconomic potential, but lack of information about its cultivation hinders its domestication. Here, we aimed to evaluate the acclimatization and vegetative development of mandacaru under different substrates and irrigation levels. For this, seeds inoculated in vitro were grown for 120 days, being transplanted to pots containing four types of substrate (S1-caatinga soil + gravel; S2-washed sand + organic matter + soil + charcoal; S3-washed sand + cattle manure + soil + sand; S4-commercial organic substrate). Pots were irrigated with 100% of the field capacity (FC) once-a-week, or with 50% FC twice-a-week, and kept in a greenhouse for six months. The experimental design was completely randomized, in a 4 × 2 factorial scheme, with six replications. Plant height and diameter, axial and radial growth rate, fresh and dry mass of stem and root, water content, and photosynthetic pigments were determined. Growth was affected mainly by the substrate, with S4 resulting in higher growth and pigment content, while S1 was impaired and S2 and S3 resulted in intermediate growth. The use of S4 and 100% FC once per week was the best condition for mandacaru.

A clinical model to predict successful renal replacement therapy (RRT) discontinuation in patients with Acute Kidney Injury (AKI).

INTRODUCTION: Ideal timing of Renal Replacement Therapy (RRT) discontinuation in Acute Kidney Injury (AKI) is still unknown. We aimed to study the role of creatinine-related variables in predicting RRT successful discontinuation and to propose a clinical predictive score. METHODS: In this single-centre retrospective study, we evaluated all AKI patients in whom RRT was interrupted for at least 48 hours. Patients who were still RRT-independent 7 days after initial RRT cessation were included in the "Success" group and opposed to the "Failure" group. We evaluated baseline characteristics and variables collected at the time of RRT interruption, as well as the Kinetic estimated Glomerular Filtration Rate (KeGFR), the simple variation in serum Creatinine (ΔsCr), and the incremental creatinine ratio on the first three days after RRT interruption. Multivariable analysis was performed to evaluate prediction of success. Internal validation using a simple binomial generalized regression model with Lasso estimation and 5-fold cross validation method was performed. RESULTS: We included 124 patients, 49 in the "Failure" group and 75 in the "Success" group. All creatinine-related variables predicted success in simple and multiple logistic regression models. The best model generated a clinical score based on the odds ratio obtained for each variable and included urine output, non-renal SOFA score, fluid balance, serum urea, serum potassium, blood pH, and the variation in sCr values after RRT discontinuation. The score presented an area under the ROC of 0.86 (95% CI 0.76‒1.00). CONCLUSION: Creatinine variation between the first 2 consecutive days after RRT discontinuation might predict success in RRT discontinuation. The developed clinical score based on these variables might be a useful clinical decision tool to guide hemodialysis catheter safe removal.

Reference values for the cross-sectional area of the lumbar multifidus muscle in children.

BACKGROUND: The multifidus muscle plays a major role in the growth and postural control of children. Therefore, the reference values of the cross-sectional area (CSA) of the lumbar multifidus muscle represent an important tool for assessing muscle development and the early monitoring of musculoskeletal disorders. OBJECTIVE: The aim of this study was to provide percentile scores for the CSA of the lumbar multifidus muscle in eutrophic children aged 5 to 10 years. METHODS: This was a cross-sectional, observational study, involving 736 children. An anthropometric assessment was conducted and ultrasound (US) imaging was used to assess the CSA of the lumbar (vertebral level L5) multifidus muscle. The CSA was expressed as percentile scores. RESULTS: The CSA in the boys ranged from 1.8 cm2 to 5.3 cm2 and in girls from 1.9 cm2 to 5.9 cm. The CSA in the 50th percentile scores of both sexes was 3.4 cm2. There was an increase in the CSA between 5 and 7 years old in both sexes. The CSA presented a greater variance in girls than in boys. After 8 years of age, the multifidus CSA increased in girls and decreased in boys. CONCLUSION: The present study has provided percentile scores for the CSA of the lumbar multifidus muscle for eutrophic children aged 5 to 10 years. An increase was observed of the CSA of the multifidus muscle between the ages of 5 and 7 years and there were no differences in the CSA percentiles in relation to sex. An increase in the CSA after 8 years of age was only observed in the girls.

Home exercises for neck pain: A Delphi survey.

PURPOSE: The current context of the COVID-19 pandemic has demonstrated the need for home exercise strategies for the relief of neck pain, which, in recent times, has increased. However, there is a gap regarding home exercises that are aimed at reducing neck pain. Therefore, the aim of this study was to develop, validate and culturally adapt a home exercise protocol for neck pain. METHODS: This was an observational study conducted in three stages: (1) Developing an online search of databases for articles on neck pain exercises. (2) Validating a panel of 12 physical therapists, using the Delphi technique, and (3) Cultural adaptation, through face-to-face assessment with individuals aged 18-30 years with neck pain (n = 15). This resulted in the production of a final version of the protocol. Consensus on the protocol items (using the five-point Likert scale) was considered when the percent agreement was equal to or greater than 75%. Individuals were also asked about pain intensity during the last week before and after performing the protocol. RESULTS: A protocol was developed with the principles of neck and scapular stabilization and upper limb movements, for a period of 4 weeks. Nine physical therapists completed two rounds online, and all items in the second version of the protocol presented an agreement of over 75%. The protocol was culturally adapted by the target population, in which 73% of individuals presented pain reduction with a minimally clinically important difference. CONCLUSION: A 4-week home exercise protocol was created based on the best evidence in the literature, was validated by physical therapists and adapted for the population with neck pain. It proved to be an understandable, useful, practical and convenient tool in the treatment of this disorder and demonstrated an improvement in neck pain. CLINICALTRIALS: GOV: (NCT04187001).

Evaluation of Antifungal Activity and Potential Application as Fluorescent Probes of Indolenine and Benzo[e]Indole-Based Squarylium Dyes.

The antifungal performance and the possible use as fluorescent probes of a series of squarylium dyes derived from indolenine and benzo[e]indole previously synthesized was evaluated. Some photophysical properties were performed in ethanol and phosphate buffer, and the type of aggregates form in phosphate buffer was analyzed. Using the 1,3-diphenylisobenzofuran assay, a qualitative assessment of the capacity of dyes to produce singlet oxygen after irradiation was performed. Regarding the antifungal activity, this was studied through a broth microdilution assay using Saccharomyces cerevisiae PYCC 4072 as a biological model. The effect of irradiation of the dyes, with an appropriate light emitting diode system, on the antifungal activity was also evaluated, and it was verified that some of the dyes improve their activity after irradiation. Using fluorescence microscopy techniques, the colocalization of dyes in S. cerevisae cells was investigated and it was possible to verify that some of the squarylium dyes with a barbituric moiety in the four-membered central ring stained and accumulated preferentially in the mitochondrial web and perinuclear membrane of the cells. The possible use as a fluorescent probe for the detection of HSA was also evaluated for one of the dyes of the series, demonstrating a linear variation in the fluorescence intensity accompanied by the increase in the protein concentration.

Rock n' Seeds: A database of seed functional traits and germination experiments from Brazilian rock outcrop vegetation.

Advancing functional ecology depends fundamentally on the availability of data on reproductive traits, including those from tropical plants, which have been historically underrepresented in global trait databases. Although some valuable databases have been created recently, they are mainly restricted to temperate areas and vegetative traits such as leaf and wood traits. Here, we present Rock n' Seeds, a database of seed functional traits and germination experiments from Brazilian rock outcrop vegetation, recognized as outstanding centers of diversity and endemism. Data were compiled through a systematic literature search, resulting in 103 publications from which seed functional traits were extracted. The database includes information on 16 functional traits for 383 taxa from 148 genera, 50 families, and 25 orders. These 16 traits include two dispersal, six production, four morphological, two biophysical, and two germination traits-the major axes of the seed ecological spectrum. The database also provides raw data for 48 germination experiments, for a total of 10,187 records for 281 taxa. Germination experiments in the database assessed the effect of a wide range of abiotic and biotic factors on germination and different dormancy-breaking treatments. Notably, 8255 of these records include daily germination counts. This input will facilitate synthesizing germination data and using this database for a myriad of ecological questions. Given the variety of seed traits and the extensive germination information made available by this database, we expect it to be a valuable resource advancing comparative functional ecology and guiding seed-based restoration and biodiversity conservation in tropical megadiverse ecosystems. There are no copyright restrictions on the data; please cite this paper when using the current data in publications; also the authors would appreciate notification of how the data are used in publications.

O avanço da ecologia funcional depende fundamentalmente da disponibilidade de dados sobre traços reprodutivos, incluindo dados de plantas tropicais, que têm sido historicamente subrepresentados em bancos de dados de traços funcionais globais. Embora alguns bancos de dados valiosos tenham sido criados recentemente, eles são restritos principalmente a áreas temperadas e a traços vegetativos, como traços de folhas e madeira. Neste artigo apresentamos Rock n' Seeds, um banco de dados de traços funcionais de sementes e experimentos de germinação de vegetações associadas a afloramentos rochosos do Brasil, os quais são reconhecidos como centros notáveis de diversidade e endemismo. Os dados foram compilados através de uma revisão sistemática na literatura, resultando em 103 publicações das quais foram extraídos os traços funcionais das sementes. O banco de dados inclui informações de 16 traços funcionais para 383 taxa de 148 gêneros, 50 famílias e 25 ordens. Estes dezesseis traços incluem dois traços de dispersão, seis de produção, quatro morfológicos, dois biofísicos e dois germinativos; os eixos principais do espectro ecológico da semente. O banco de dados também fornece os dados brutos para 48 experimentos de germinação para um total de 10.187 registros para 281 taxa. Os experimentos de germinação no banco de dados avaliaram o efeito de uma ampla gama de fatores abióticos e bióticos sobre a germinação e diferentes tratamentos de quebra de dormência. Particularmente, 8.255 desses registros incluem a contagem diária da germinação. Estas informações facilitarão a síntese de dados de germinação e a utilização deste banco de dados para uma grande variedade de questões ecológicas. Dada a variedade de traços das sementes e as amplas informações sobre germinação disponibilizadas por este banco de dados, esperamos que ele seja um recurso valioso para o avanço da ecologia funcional comparativa e para orientar a restauração baseada em sementes e a conservação da biodiversidade em ecossistemas tropicais megadiversos. Não há restrições de direitos autorais sobre os dados; favor citar este artigo ao utilizar os dados nas publicações e os autores agradeceriam uma notificação de como os dados são utilizados nas publicações.

El avance de la ecología funcional depende fundamentalmente de la disponibilidad de datos sobre rasgos reproductivos-incluyendo los de las plantas tropicales-los cuales han estado poco representados en las bases de datos globales de rasgos. Aunque recientemente se han creado algunas bases de datos valiosas, estas se encuentran restringidas principalmente a las zonas templadas y a los rasgos vegetativos, como los de las hojas y la madera. En este artículo presentamos Rock n' Seeds, una base de datos de rasgos funcionales de semillas y experimentos de germinación de la vegetación asociada a afloramientos rocosos de Brasil, los cuales son destacados centros de diversidad y endemismo. Los datos se recopilaron mediante una búsqueda bibliográfica sistemática, que dio como resultado 103 publicaciones de las que se extrajeron los rasgos funcionales de las semillas. La base de datos incluye información de dieciséis rasgos funcionales para 383 taxones de 148 géneros, 50 familias y 25 órdenes. Estos rasgos incluyen dos rasgos de dispersión, seis de producción, cuatro morfológicos, dos biofísicos y dos de germinación; siendo estos los principales ejes del espectro ecológico de las semillas. La base de datos también proporciona los datos brutos de 48 experimentos de germinación, para un total de 10.187 registros de 281 taxones. Dichos experimentos de germinación evaluaron el efecto de una amplia gama de factores abióticos y bióticos sobre la germinación y de diferentes tratamientos para romper la dormancia. En particular, 8.255 de estos registros cuentan con conteos diarios de germinación. Esto facilitará la síntesis de los datos de germinación y el uso de esta base de datos para una gran diversidad de preguntas ecológicas. Dada la variedad de rasgos de las semillas y la amplia información sobre germinación que ofrece esta base de datos, esperamos que sea un recurso valioso para el avance de la ecología funcional comparativa y para orientar la restauración basada en semillas y la conservación de la biodiversidad en ecosistemas tropicales megadiversos. No hay restricciones de derechos de autor sobre los datos; se solicita citar este documento cuando se utilicen los datos en publicaciones y los autores agradecerán ser notificados sobre cómo se utilizan los datos en las publicaciones.

The accuracy of computerized biophotogrammetry in diagnosing changes in the cervical spine and its reliability for the cervical lordosis angle.

BACKGROUND: Accuracy studies of biophotogrammetry protocols require standardization similar to radiography. OBJECTIVE: To estimate the diagnostic accuracy of a biophotogrammetric assessment protocol for cervical hyperlordosis, compared to radiography, and its intra- and inter-examiner reliability for measuring the cervical lordosis angle. METHODS: A study of diagnostic accuracy in women complaining of cervical pain. Two photos were taken using the CorelDraw biophotogrammetric protocol and one radiograph using the Cobb C1-C7 method. The Intra- and Inter-examiner reliability was calculated using the Kappa index and the intraclass correlation coefficient (ICC). The Bland-Altman plot and the ROC curve were presented. RESULTS: The sample consisted of 19 women. The accuracy of biophotogrammetry was 94.73% and the reliability between biophotogrammetry and radiography presented an ICC of 0.84 and a Kappa of 0.87. The excellent intra (ICC = 0.94) and inter-examiner (ICC = 0.86) reliability of the biophotogrammetry was confirmed. The area under the ROC curve was 93.5%. The Bland-Altman plot indicated differences between the two instruments close to the mean (1.5∘). CONCLUSION: The biophotogrammetric protocol proved to be accurate in diagnosing cervical hyperlordosis, with excellent reliability between the biophotogrammetric and radiographic assessments. It also demonstrated excellent intra- and inter-examiner reliability in measuring the cervical lordosis angle.

Estratégias preventivas no enfrentamento da covid-19 na população indígena: revisão de escopo

Objetivo: Mapear as produções científicas sobre as estratégias preventivas utilizadas pelos serviços de saúde no enfrentamento da Covid-19 na população indígena do continente americano no período de 2019 a 2022. Material e Método: Revisão de escopo, realizada nas bases de dados: LILACS, MEDLINE, SCOPUS, EMBASE, WOS e Science Direct. Seguindo os critérios estabelecidos pela estratégia do mnemônico PCC, utilizaram-se descritores controlados e não controlados. Foram incluídos estudos primários, relatos de experiências, revisões de literatura, perspectivas, reflexões e editoriais, publicados no período dezembro de 2019 a março de 2022, nos idiomas português, inglês e espanhol. Resultados: Foram identificados nas estratégias de buscas 237 estudos e, a partir da leitura dos textos na íntegra, seis artigos foram selecionados para esta revisão. A exploração dos estudos publicados nos periódicos internacional e nacional, permitiram o mapeamento das estratégias preventivas utilizadas pelos serviços de saúde e pelas comunidades indígenas, que incluíram isolamento nas aldeias, remoção de pacientes, tratamento de doenças não relacionadas a Covid-19 nas aldeias, compra de equipamentos de proteção individual, educação em saúde com materiais linguisticamente apropriados e apoio financeiro. Também houve estudos que apresentavam possíveis sugestões para a prevenção e o combate à Covid-19. Conclusão: As estratégias preventivas tinham a finalidade de conter a disseminação desta doença infectocontagiosa nas comunidades indígenas, mas também observou-se uma escassez de estratégias no âmbito da enfermagem que atuem de acordo com as especificidades culturais desses povos originários.

Objective: To map the scientific production on the preventive strategies used by health services to combat Covid-19 in the indigenous population of the American continent from 2019 to 2022. Materials and Methods: Scoping review carried out in the databases: LILACS, MEDLINE, SCOPUS, EMBASE, WOS and Science Direct. Controlled and non-controlled descriptors were used following the criteria established by the PCC mnemonic strategy. Primary studies, experience reports, literature reviews, perspectives, reflections and editorials, published between December 2019 and March 2022, in Portuguese, English and Spanish were included. Results: 237 studies were identified in the search strategies, and after reading the full texts, six articles were selected for this review. The exploration of studies published in international and national journals allowed the mapping of preventive strategies used by health services and indigenous communities, which included isolation in the villages, transfer of patients, treatment of diseases not related to Covid-19 in the villages, purchase of personal protective equipment, health education with linguistically appropriate materials and financial support. There were also studies that presented possible suggestions for preventing and combating Covid-19. Conclusion: The preventive strategies were intended to contain the spread of this infectious disease in indigenous communities, but there was also a lack of strategies in the nursing field that respond to the cultural specificities of the indigenous population.

Objetivo: Mapear la producción científica sobre las estrategias preventivas utilizadas por los servicios de salud para el abordaje del Covid-19 en la población indígena del continente americano entre los años 2019 y 2022. Material y Método: Revisión de alcance realizada en las bases de datos: LILACS, MEDLINE, SCOPUS, EMBASE, WOS y Science Direct. Siguiendo los criterios establecidos por la estrategia mnemotécnica PCC, se utilizaron descriptores controlados y no controlados. Se incluyeron estudios primarios, informes de experiencias, revisiones bibliográficas, perspectivas, reflexiones y editoriales, publicados entre diciembre de 2019 y marzo de 2022, en portugués, inglés y español. Resultados: Se identificaron 237 estudios en las estrategias de búsqueda, y después de leer los textos completos, se seleccionaron seis artículos para esta revisión. La exploración de estudios publicados en revistas internacionales y nacionales permitió mapear las estrategias preventivas utilizadas por los servicios de salud y las comunidades indígenas, que incluían el aislamiento en las aldeas, el traslado de pacientes, el tratamiento de enfermedades no relacionadas con el Covid-19 en las aldeas, la compra de equipos de protección personal, la educación sanitaria con materiales lingüísticamente apropiados y el apoyo financiero. También hubo estudios que presentaban posibles sugerencias para prevenir y combatir el Covid-19. Conclusión: Las estrategias preventivas tuvieron como objetivo contener la propagación de esta enfermedad infecciosa en las comunidades indígenas, pero también se pudo observar la falta de estrategias en el campo de la enfermería que actúen de acuerdo con las especificidades culturales de la población indígena.

A clinical model to predict successful renal replacement therapy (RRT) discontinuation in patients with Acute Kidney Injury (AKI)

Abstract Introduction Ideal timing of Renal Replacement Therapy (RRT) discontinuation in Acute Kidney Injury (AKI) is still unknown. We aimed to study the role of creatinine-related variables in predicting RRT successful discontinuation and to propose a clinical predictive score. Methods In this single-centre retrospective study, we evaluated all AKI patients in whom RRT was interrupted for at least 48 hours. Patients who were still RRT-independent 7 days after initial RRT cessation were included in the "Success" group and opposed to the "Failure" group. We evaluated baseline characteristics and variables collected at the time of RRT interruption, as well as the Kinetic estimated Glomerular Filtration Rate (KeGFR), the simple variation in serum Creatinine (ΔsCr), and the incremental creatinine ratio on the first three days after RRT interruption. Multivariable analysis was performed to evaluate prediction of success. Internal validation using a simple binomial generalized regression model with Lasso estimation and 5-fold cross validation method was performed. Results We included 124 patients, 49 in the "Failure" group and 75 in the "Success" group. All creatinine-related variables predicted success in simple and multiple logistic regression models. The best model generated a clinical score based on the odds ratio obtained for each variable and included urine output, non-renal SOFA score, fluid balance, serum urea, serum potassium, blood pH, and the variation in sCr values after RRT discontinuation. The score presented an area under the ROC of 0.86 (95% CI 0.76‒1.00). Conclusion Creatinine variation between the first 2 consecutive days after RRT discontinuation might predict success in RRT discontinuation. The developed clinical score based on these variables might be a useful clinical decision tool to guide hemodialysis catheter safe removal.

Youtube™ como ferramenta de ensino sobre antibioticoterapia em odontopediatria / Youtube™ as a teaching tool on antibiotic therapy in pediatric dentistry

Objetivo: objetivou-se avaliar a qualidade das informações fornecidas por vídeos no YoutubeTM sobre antibioticoterapia na odontopediatria. Materiais e Métodos: foram incluídos vídeos relacionados a antibioticoterapia, em português e destinados a dentistas. Os vídeos foram revisados por dois avaliadores para extração de dados quantitativos e a qualidade do seu conteúdo foi avaliado utilizando um checklist, contendo 22 pontos, elaborado com base nas recomendações das associações internacionais de odontopediatria. A qualidade dos vídeos foi classificada em baixa (0-11 pontos) ou alta (12-22 pontos). Os resultados foram apresentados de forma descritiva e testes estatísticos foram aplicados para avaliar a associação (ANOVA) ou correlação (Pearson) entre a população final do vídeo e seus dados quantitativos. Resultados: dos 7 vídeos incluídos, apenas 1 apresentou alta qualidade. O conteúdo abordado pelos vídeos foi heterogêneo, onde 85% (n=6) citaram amoxicilina como antibiótico de primeira escolha e 71% (n=5) relataram a remoção da fonte de infecção como suficiente em crianças saudáveis. Nenhum vídeo citou indicação para testes de cultura e sensibilidade, a contraindicação de antibioticoterapia em casos de gengivite, luxações, fraturas radiculares. A fonte do vídeo, quantidade de likes e visualizações não estão relacionadas a sua pontuação final (p>0,05), entretanto, o seu tempo está fortemente relacionado a sua pontuação (r=0,8, p=0,03). Conclusão: pode-se concluir que a qualidade do conteúdo de vídeos sobre antibioticoterapia destinados a dentistas brasileiros é baixa, não abordando de forma completa as recomendações das entidades de classe relacionadas ao tema, e o tempo do vídeo está fortemente correlacionado a sua pontuação final.

Objective: the objective of this study was to evaluate the quality of information provided by videos on YoutubeTM about antibiotic therapy in pediatric dentistry. Materials and Methods: videos related to antibiotic therapy, in Portuguese and intended for dentists were included. The videos were reviewed by two evaluators to extract their quantitative data and their quality content was evaluated using a checklist with 22 points, prepared based on the recommendations of different international dentistry associations. Video quality was rated as low (0-11 points) or high (12-22 points). Results were presented descriptively, and statistical tests were applied to assess the association (ANOVA) or correlation (Pearson) between the final video population and their quantitative data. Results: of the 7 videos included, only 1 present high quality. Videos content was heterogeneous, where 85% (n=6) cited amoxicillin as a firstchoice antibiotic and 71% (n=5) reported removing the source of infection as sufficient in healthy children. No video cited indication for culture and sensitivity tests, the contraindication of antibiotic therapy in cases of gingivitis, luxation's and root fractures. The video source, number of likes and views are not related to your final score (p>0.05), however, your time is strongly corelated to your score (r=0.8, p=0.03). Conclusion: it can be concluded that the quality of the content of videos on antibiotic therapy for Brazilian dentists is low, not fully addressing the recommendations of dentistry associations related to the topic, and the length of the video is strongly correlated with its final score.

Potential adverse drug events: intensive care unit cohort / Potenciais eventos adversos a medicamentos: coorte em unidades de terapia intensiva

Introdução: Eventos adversos a medicamentos estão associados à morbimortalidade, altas taxas de permanência hospitalar e custos elevados. Pacientes de unidade de terapia intensiva são um dos principais grupos de risco para ocorrência desses eventos. O uso de rastreadores, indicadores de potenciais eventos, pode simplificar a detecção por meio do screening sistemático de prontuários e possibilitar mensuração contínua. Objetivo: Analisar potenciais eventos adversos e correlacionar seus rastreadores com tempo de internação, número de medicamentos e comorbidades em pacientes internados em unidade de terapia intensiva adulto. Métodos: Estudo longitudinal conduzido com pacientes internados em terapia intensiva de um hospital de alta complexidade de São Paulo, Brasil. Amostra probabilística composta por 83 prontuários de pacientes, hospitalizados, por no mínimo 24 horas, para tratamento clínico e que receberam, pelo menos, um medicamento. Na identificação dos eventos foi utilizado o instrumento do Institute for Healthcare Improvement adaptado, que inclui rastreadores, medicamentos, bioquímicos e clínicos. As análises estatísticas foram realizadas pela Correlação de Pearson, com significância de p<0,05. Resultados: Anti-histamínicos (43,4%), aumento de creatinina (50,6%) e letargia (20,5%) foram os rastreadores mais frequentes de cada categoria. Os medicamentos mais utilizados foram ácido acetilsalicílico (67%) e omeprazol (55%). Houve correlação positiva entre o número total de rastreadores e tempo de internação, número de medicamentos e comorbidades (r= 0,961, r=0,555 e r=0,210 respectivamente; p<0,001). Conclusão: Os rastreadores destacados são esperados para pacientes com cardiopatias em unidades de terapia intensiva e sugerem alerta para os profissionais envolvidos no monitoramento de eventos adversos (AU)

Introduction: Adverse drug events are associated with morbidity and mortality, high hospital stay rates and high costs. Intensive care unit patients are one of the main risk groups for the occurrence of these events. The use of triggers, which indicate potential events, can simplify detection by systematic screening of medical records and enables continuous measurement. Objective: Analyze potential adverse events and correlate their triggers with the length of stay, number of medications, and comorbidities in patients admitted to an adult intensive care unit. Methods: A longitudinal study was conducted with patients admitted to intensive care at high complexity hospital in São Paulo, Brazil. A probabilistic sample consisting of medical records of 83 patients hospitalized, for at least 24 hours, for clinical treatment and who received at least one medication. In the identification of the events the adapted instrument of the Institute for Healthcare Improvement was used, which includes drug, biochemical, and clinical triggers. The Pearson's correlation test was used to correlate the number of triggers with the length of stay, the number of medications, and comorbidities, and the significance of p<0.05. Results: Antihistamines (43.4%), creatinine increase (50.6%), and lethargy (20.5%) were the most frequent triggers for each category. Among the drugs, acetylsalicylic acid (67%) and omeprazole (55%) were prominent. There was a positive correlation between the total number of triggers and time of hospitalization, the number of medications, and comorbidities (r=0.961, r=0.555, and r=0,210 respectively; p<0.001). Conclusions: Outstanding triggers can be expected for intensive care units' cardiac patients and suggest warning for professionals involved in monitoring these events (AU)

Effectiveness of cardiopulmonary resuscitation training in the teaching of family members of cardiac patients.

OBJECTIVE: To evaluate the effectiveness of a cardiopulmonary resuscitation training in the skill acquisition of family members of heart disease patients. METHOD: A quasi-experimental study, conducted in a hospital in São Paulo, Brazil. The study participants were one or more relatives of patients with heart disease that were hospitalized at the institution. In the first phase, the participant's skills and theoretical knowledge on cardiopulmonary resuscitation were evaluated before and immediately after the training. The second phase took place one month after the training, in which the same evaluations were applied. The McNemar's and Stuart-Maxwell tests were adopted (5% significance level). RESULTS: The theoretical knowledge of family members before and after training increased and a great retention of this knowledge after 30 days of training was observed. Immediately after training, the family members showed significant improvement of skills in the 15 analyzed actions and, after one month of training, they maintained most of the acquired practices on cardiopulmonary resuscitation, except for chest compressions frequency and the time between turning on the defibrillator and delivering the shock. CONCLUSION: Cardiopulmonary resuscitation training was effective in the acquisition of theoretical and practical knowledge of the family members.

Influence of different Eucalyptus hybrids on soil macrofauna.

The present work aimed to evaluate the influence of different eucalyptus hybrids on the edaphic macrofauna community. It is hypothesized that the density and diversity of edaphic fauna are influenced by the quantity and quality of the litter deposited by the different hybrids on the soil surface. The study area is in the city of Vitória da Conquista (BA) and consists of seven eucalyptus hybrids, one from sexual reproduction (seminal) and six from asexual (clonal) reproduction. Sampling of the soil macrofauna was performed by the Tropical Soil Biology and Fertility method. All visible invertebrates were collected and identified at the level of large taxonomic groups. The relative density, group richness, and diversity index were calculated. Hybrids did not influence the total density and richness of the soil macrofauna. However, it was possible to observe changes in litter accumulation and composition, and as a result in the diversity indexes and in the presence or absence of macrofauna groups. Among the studied hybrids, those from Eucalyptus urophylla (seminal, 1335 and 1249) promote greater macrofauna diversity and favor the occurrence of detritivores organisms, suggesting the occurrence of better quality and more palatable litter for the edaphic fauna.

Squaraine Dyes Derived from Indolenine and Benzo[e]indole as Potential Fluorescent Probes for HSA Detection and Antifungal Agents.

Four squaraine dyes derived from 2,3,3-trimethylindolenine and 1,1,2-trimethyl-1H-benzo[e]indole with different combinations of barbituric groups attach to the central ring, having ester groups and alkyl chains in the nitrogen atoms of heterocyclic rings were synthesized. These dyes were fully characterized, and their photophysical behavior was studied in ethanol and phosphate-buffered solution. Absorption and emission bands between 631 and 712 nm were detected, with the formation of aggregates in aqueous media, which is typical of this class of dyes. Tests carried out with 1,3-diphenylisobenzofuran allowed us to verify the ability of the dyes to produce singlet oxygen. The interaction of synthesized dyes with human serum albumin (HSA) was also evaluated, being demonstrated a linear correlation between fluorescence intensity and protein concentration. The antifungal potential of the dyes against the yeast Saccharomyces cerevisiae was evaluated using a broth microdilution assay. In order to test the photosensitizing capacity of the synthesized dyes, tests were carried out in the dark and with irradiation, using a custom-built light-emitting diode that emits close to the absorption wavelength of the studied dyes. The results showed that the interaction of dyes with HSA and the antifungal activity depends on the different structural modifications of the dyes.

Extracts and purified substances of Cabralea canjerana inhibit hatching and extracts of Schinus terebinthifolius kill juveniles of meloidogyne incognita

Nematicidal substances have been identified from plants and are potentially useful for the management of plant-parasitic nematodes. Cabralea canjerana, (Meliaceae) and Schinus terebinthifolius (Anacardiaceae) produce bioactive compounds during their secondary metabolism and little is known about the effect of such substances on plant-parasitic nematodes. In the present study, we assessed the effect of aqueous and ethanolic extracts of C. canjerana and S. terebinthifolius at 1% (m:v) and purified substances from C. canjerana (gedunin, ocotillone, cabraleadiol, a mixture of ocotillone + cabraleadiol and a mixture of shoreic acid + eichlerianic acid) on hatching and mortality of Meloidogyne incognita juveniles. Aqueous extracts of C. canjerana fruits and seeds reduced hatching by 70.3 to 95.7%. Aqueous extracts of S. terebinthifolius fruits killed 42.8 to 77.1% of juveniles. The purified substances of C. canjerana inhibited the hatching of M. incognita from 57 to 90% and did not increase the mortality of juveniles. Therefore, C. canjerana extracts and its purified substances reduce M. incognita hatching and aqueous extracts of S. terebinthifolius kill J2 of this nematode.

Postura, mobilidade diafragmática e função pulmonar em crianças e adolescentes obesos Autores Patrícia Clara Pereira dos Santos / Posture, diaphragmatic mobility and pulmonary function in obese children and adolescents

Introdução: A sobrecarga corporal devida à obesidade contribui no surgimento de alterações no sistema musculoesquelético e respiratório. Objetivo: Analisar as evidências científicas referentes à influência da obesidade sobre a postura do tronco, a resposta cinético-funcional do diafragma e a função pulmonar em crianças e adolescentes. Métodos: Trata-se de uma revisão de literatura, utilizando as bases de dados Medline, Cochrane, Embase, Lilacs e Web of Sciences, nos idiomas inglês, português e espanhol, nos últimos 10 anos. Foram utilizados os descritores: "obesidade', "postura", "diafragma", "função pulmonar", "adolescentes", "adultos jovens". Os critérios de exclusão foram: estudos que abordaram distúrbios neuromusculares associados, cifoescoliose, fibrose cística, enfisema pulmonar, asma e DPOC e artigos não disponíveis na íntegra. Resultados: Foram identificados 226 estudos, porém 10 foram analisados. Os resultados apontaram que a postura do tronco nos obesos é hipercifótica, hiperlordótica e com anteversão pélvica, além de apontar indícios de repercussão na dinâmica respiratória, com redução da mobilidade do diafragma e dos volumes e capacidades pulmonares. Conclusão: A obesidade contribui para a ocorrência de hipercifose, hiperlordose e anteversão da pelve, bem como na diminuição da atividade do diafragma e função pulmonar. (AU)

Atuação da enfermagem na assistência a população indígena do polo base do interior do Amazonas / Rol de enfermería en la asistencia al población indígena del polo base del interior de la Amazonas / Nursing activities in the care of the indigenous population of the base pole of the interior of the Amazon

Objetivo: conhecer a atuação da equipe de enfermagem na assistência a população indígena do polo base Mamori. Método: estudo descritivo, exploratório e transversal com abordagem qualitativa, realizado no período de dezembro de 2019 a janeiro de 2020, com quatro enfermeiros e oito técnicos de enfermagem que prestam assistência no polo base de Mamori no município de Eirunepé do Estado do Amazonas. Os dados foram coletados através de um roteiro de entrevista, após foram transcritas na integra e submetida a análise dos dados, que seguiram as etapas da análise temática de Minayo. Resultados: foram identificadas duas categorias, desvelando-se as ações da equipe de enfermagem (1), os a atualização ao contexto social e cultural dos povos indígenas (2). Conclusão: a equipe de enfermagem desempenha uma ação atuante de acordo com as especificidades das duas etnias, ao possuir uma assistência criativa, fazendo uso de estratégias que se relacionam e respeitam os saberes tradicionais.(AU)

Objective: to understand the performance of the nursing team in assisting the indigenous population of the Mamori hub. Method: descriptive, exploratory and cross-sectional study with a qualitative approach, conducted in the period from December 2019 to January 2020, with four nurses and eight nursing technicians who provide care in the Mamori hub in the municipality of Eirunepé in the State of Amazonas. The data were collected through an interview script, after they were transcribed in full and subjected to data analysis, which followed the steps of Minayo's thematic analysis. Results: two categories were identified, unveiling the actions of the nursing team (1), and the update to the social and cultural context of indigenous peoples (2). Conclusion: the nursing team performs an active action according to the specificities of the two ethnicities, by having a creative assistance, making use of strategies that relate to and respect the traditional knowledge.(AU)

Objetivo: conocer la actuación del equipo de enfermería en la asistencia a la población indígena del núcleo de Mamori. Método: estudio descriptivo, exploratorio y transversal con enfoque cualitativo, realizado en el período de diciembre de 2019 a enero de 2020, con cuatro enfermeras y ocho técnicos de enfermería que prestan atención en el núcleo de Mamori en el municipio de Eirunepé en el Estado de Amazonas. Los datos se recogieron mediante un guión de entrevista, tras lo cual se transcribieron en su totalidad y se sometieron a un análisis de datos, que siguió los pasos del análisis temático de Minayo. Resultados: se identificaron dos categorías, revelando las acciones del equipo de enfermería (1), la actualización al contexto social y cultural de los pueblos indígenas (2). Conclusión: el equipo de enfermería desempeña una actuación acorde con las especificidades de las dos etnias, a fin de contar con una asistencia critica, haciendo uso de estrategias que se relacionan y se inspiran en los conocimientos tradicionales.(AU)

Sexual violence perpetrated by health professionals.

Sexual violence (SV) perpetrated by health professionals concerns any sexual conduct, whether physical or verbal (with or without contact), toward a patient. There has been little scientific study and some disagreements have emerged regarding its definition, which has even been confused with violation of professional boundaries. In this descriptive-exploratory study, we aimed to characterize this phenomenon in the Portuguese context, using a sample of 491 participants who completed an online questionnaire adapted for this study. The results showed that 8.96% of the participants (5.5% indirect victims) suffered SV by a health professional, and the sociodemographic characteristics are very similar to those of SV in other contexts. Thus, after confirming this is not a problem alien to the Portuguese reality, we discuss the practical implications for prevention and intervention with victims.