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Phytochemistry ; 203: 113338, 2022 Nov.
Article in English | MEDLINE | ID: mdl-35948140

ABSTRACT

Withajardins, uncommon modified withanolide-type steroids, have been isolated exclusively from plants of the Solanaceae family so far. Two undescribed withajardins and the known tuboanosigenin were isolated from the hexane/EtOAc 1:1 extract from Athenaea velutina leaves. Their structures were established by an extensive analysis of 1D and 2D-NMR and HRMS data. The absolute configuration was determined by X-ray diffraction (withajardin L and tuboanosigenin) and circular dichroism (CD) analyses (withajardin M). The anti-inflammatory activity of compounds was evaluated through the inhibition of the lipopolysaccharide (LPS)-induced nitric oxide (NO), TNF-α, and IL-6 release in RAW264.7 cells. The cell viability effects to RAW 264.7 cells showed IC50 values of 74.4-354.4 µM. The compounds attenuated LPS-induced release of NO and decreased pro-inflammatory cytokines TNF-α and IL-6 in RAW264.7 cells.


Subject(s)
Anti-Inflammatory Agents , Plant Extracts , Solanaceae , Withanolides , Animals , Anti-Inflammatory Agents/chemistry , Anti-Inflammatory Agents/pharmacology , Interleukin-6 , Lipopolysaccharides , Mice , Nitric Oxide , Plant Extracts/chemistry , Plant Extracts/pharmacology , RAW 264.7 Cells , Solanaceae/chemistry , Tumor Necrosis Factor-alpha , Withanolides/chemistry , Withanolides/pharmacology
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