ABSTRACT
Cutaneous T cell lymphomas most commonly have a CD4+ memory T cell phenotype and exhibit a relatively indolent course, but may in rare cases present with a CD8+ cytotoxic phenotype with a strikingly more aggressive clinical behavior. Primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma is an extremely rare entity with distinct clinicopatological features. The clinical features and prognosis of the recently-described CD8+ peripheral lymphoma are very different from cytotoxic CD8+ epidermotropic lymphoma, but the histological and phenotypic characteristics are very similar. We report a new case of CD8+ epidermotropic lymphoma with a chronic course and suggest the possibility of an overlap between these two types of lymphoma.
Subject(s)
Lymphoma, T-Cell, Cutaneous/diagnosis , Skin Neoplasms/diagnosis , Aged , Antigens, CD/analysis , Antigens, CD/immunology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , CD8-Positive T-Lymphocytes/immunology , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Female , Humans , Ki-67 Antigen/analysis , Ki-67 Antigen/immunology , Lymphoma, T-Cell, Cutaneous/drug therapy , Lymphoma, T-Cell, Cutaneous/immunology , Lymphoma, T-Cell, Cutaneous/radiotherapy , Lymphoma, T-Cell, Peripheral/diagnosis , Lymphoma, T-Cell, Peripheral/immunology , Neoplasm Recurrence, Local/diagnosis , Neoplasm Recurrence, Local/immunology , Prednisone/therapeutic use , Prognosis , Skin Neoplasms/drug therapy , Skin Neoplasms/immunology , Skin Neoplasms/radiotherapy , Treatment Outcome , Vincristine/therapeutic useABSTRACT
The diagnosis and management of four cases of dermatological disorders, most of which are related to the endocrine disorder of androgen excess, are presented. Combined oral contraceptives (COCs) may be useful when well-tolerated hormonal therapy and/or when contraception is required. A female patient with androgenetic alopecia or female pattern balding, without underlying hyperandrogenism, was treated with ethinylestradiol/chlormadinone acetate (EE/CMA) 0.03 mg/2 mg for 6 months and experienced stabilization of hair loss (case report 1). A patient who had previously received a COC for an irregular menstrual pattern but again experienced irregular menses and also acne after stopping treatment was diagnosed with acne associated with polycystic ovary syndrome (PCOS) [case report 2]. After 6 month's treatment with EE/CMA 0.03 mg/2 mg, this patient had fewer acne lesions and became eumenorrheic. A third patient who had excess hair since childhood was diagnosed with idiopathic hirsutism (no underlying gynecological or endocrinological disorder was found) and was treated with EE/CMA 0.03 mg/2 mg (case report 3). Less hair growth was reported after 6 months' treatment. Case report 4 describes a patient who presented with oligomenorrhea and acne. She was diagnosed with PCOS with acne, seborrhea and mild hirsutism. Treatment with EE/CMA 0.03 mg/2 mg for 6 months resulted in improvements in her facial acne, seborrhea and hirsutism; she also became eumenorrheic. These four cases illustrate that EE/CMA may be a useful and well tolerated treatment option in the management of patients with dermatological disorders with or without hyperandrogenization.
Subject(s)
Androgens/metabolism , Chlormadinone Acetate/analogs & derivatives , Ethinyl Estradiol/analogs & derivatives , Skin Diseases/drug therapy , Adult , Chlormadinone Acetate/adverse effects , Chlormadinone Acetate/therapeutic use , Contraceptives, Oral, Combined/adverse effects , Contraceptives, Oral, Combined/therapeutic use , Ethinyl Estradiol/adverse effects , Ethinyl Estradiol/therapeutic use , Female , Humans , Skin Diseases/diagnosis , Skin Diseases/physiopathology , Treatment Outcome , Young AdultABSTRACT
Psoriasis is a chronic inflammatory skin condition that affects approximately 3% of the population. Up to 50% of patients with psoriasis have concurrent nail psoriasis, up to 30% of patients with skin psoriasis also have psoriatic arthritis and of these, approximately 80% have nail disease. The treatment of nail psoriasis is often challenging, and there is a need for new therapeutic options. Effective biological agents used in the treatment of moderate to severe chronic plaque psoriasis may represent a new therapeutic modality for this disease. A case of rapid improvement is reported in nail psoriasis under etanercept monotherapy with maintained efficacy following the withdrawal of continued therapy.
Subject(s)
Immunoglobulin G/therapeutic use , Immunologic Factors/therapeutic use , Nail Diseases/drug therapy , Psoriasis/drug therapy , Receptors, Tumor Necrosis Factor/therapeutic use , Adult , Etanercept , Humans , MaleABSTRACT
Las dermatitis de contacto por tratamientos médicos representan un problema clínico importante por su frecuencia, trascendencia y complejidad de su estudio. Hemos llevado a cabo un estudio retrospectivo sobre la incidencia de dermatitis de contacto secundaria a cuidados médicos en 1.000 pacientes atendidos consecutivamente en una unidad especializada. Los medicamentos tópicos, en particular los antibióticos (neomicina), antisépticos y conservantes (nitrofurazona y derivados mercuriales), y corticoides (budesonida) son los grupos alergénicos con mayor índice de sensibilización (AU)
Subject(s)
Humans , Dermatitis, Allergic Contact/diagnosis , Drug Hypersensitivity/diagnosis , Retrospective Studies , Administration, Topical , Risk FactorsABSTRACT
Las múltiples erupciones granulomatosas aparecidas sobre cicatrices de herpes zóster incluyen el granuloma anular, sarcoideo y tuberculoide, la vasculitis granulomatosa y la foliculitis granulomatosa. Esta última ha sido previamente descrita en sólo tres casos. Aportamos un nuevo caso de foliculitis granulomatosa postherpética en un hombre de 27 años. (AU)
Subject(s)
Adult , Male , Humans , Folliculitis/complications , Folliculitis/diagnosis , Herpesvirus 3, Human/isolation & purification , Herpesvirus 3, Human/pathogenicity , Biopsy/methods , Hypersensitivity, Delayed/diagnosis , Skin/pathology , Skin Manifestations , Granuloma/diagnosis , Granuloma/etiology , Granuloma/pathology , Herpes Zoster/immunology , Herpes Zoster/complicationsABSTRACT
Los quistes miliares son lesiones quísticas benignas secundarias a un traumatismo. Sin embargo, pueden aparecer quistes miliares primarios en párpados, mejillas, frente y genitales, después del nacimiento, en la adolescencia y en la edad adulta. Hay dos formas especiales de quistes miliares en adolescentes y adultos: la forma eruptiva y la forma en placa. Los quistes miliares en placa son una forma primaria rara que se ve principalmente en mujeres adultas en región retroauricular. Aportamos un caso de quistes miliares en placa, en una niña de 9 años, que consulta por lesiones de tres meses de evolución, sin antecedentes de traumatismo, localizadas en el dorso de la mano, en forma de lesiones agrupadas sobre base eritematosa y elevada (AU)
Subject(s)
Female , Child , Humans , Miliaria/diagnosis , Miliaria/pathology , Epidermal Cyst/complications , Epidermal Cyst/diagnosis , Epidermal Cyst/pathology , Nevus/diagnosis , Facial Dermatoses/diagnosis , Facial Dermatoses/pathology , Lichen Planus/diagnosis , Lichen Planus/pathology , Skin Diseases, Papulosquamous/diagnosis , Acanthosis Nigricans/complications , Acanthosis Nigricans/diagnosis , Mucinosis, Follicular/physiopathologyABSTRACT
Se presenta el caso de una mujer de 22 años diagnosticada de tiña inflamatoria crural por T. mentagrophytes var interdigitale.Las infecciones por dermatofitos a nivel inguinocrural son poco frecuentes en el sexo femenino. Además, T. mentagrophytes var interdigitale es un dermatofito antropofílico que generalmente produce tinea pedis no inflamatoria.Fue tratada con griseofulvina, 500 mg/día durante 4 semanas, con curación completa (AU)
