ABSTRACT
The preparation and properties of the copper(II) complex Cu(SUP)2.H2O are reported for the anti-inflammatory drug Suprofen (SUP). The diffuse reflectance spectra and magnetic moment are consistent with a dinuclear structure as found for [Cu(aspirinate)2(H2O)]2. The copper(II) complex exhibits an increased superoxide dismutase activity compared with the parent drug molecule in the nitroblue tetrazolium assay.
Subject(s)
Copper/chemistry , Organometallic Compounds/chemistry , Superoxide Dismutase/metabolism , Suprofen/analogs & derivatives , Suprofen/chemistry , Free Radical Scavengers , Models, Structural , SuperoxidesABSTRACT
The preparation and properties of the Cu(II) complex Cu(SAS)2.H2O are reported for the antiinflammatory drug Salsalate (SAS). The diffuse reflectance spectra and magnetic moments are consistent with a dinuclear structure as found for [Cu(aspirinate)2(H2O)]2. The Cu(II) complex exhibits an increased superoxide dismutase activity compared with the parent drug molecule in the nitroblue tetrazolium assay.
