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A Pilot Study of Gene Expression Modulation from Antioxidant System of Killifish Austrolebias charrua After Exposure to Roundup Transorb^®.

Gonçalves, Natiéli M; Silveira, Tony L R; Martins, Amanda W S; Dellagostin, Eduardo N; Blödorn, Eduardo B; Nunes, Leandro S; Domingues, William B; Salvi, Luana C; Costa, Patrícia G; Bianchini, Adalto; Kütter, Mateus T; Marins, Luis F F; Volcan, Matheus V; Remião, Mariana H; Campos, Vinicius F.

Bull Environ Contam Toxicol ; 113(2): 17, 2024 Jul 27.

Article in English | MEDLINE | ID: mdl-39068350

ABSTRACT

Roundup Transorb® (RDT) is the most popular glyphosate-based herbicide (GHB) used in agriculture, and its impact extends to non-target organisms. The annual killifish Austrolebias charrua is an endangered species endemic to southern South America and inhabits temporary ponds. This study evaluates the effects of RDT concentrations (0.065 and 5 mg/L GAE) on A. charrua exposed for 96 h. Gene expression of cat, sod2, gstα, gclc, and ucp1 was evaluated on the liver and gills. Highlighting that even at low concentrations permitted by Brazilian legislation, the RDT can have adverse effects on A. charrua.

Subject(s)

Antioxidants , Glycine , Glyphosate , Herbicides , Water Pollutants, Chemical , Animals , Water Pollutants, Chemical/toxicity , Herbicides/toxicity , Glycine/analogs & derivatives , Glycine/toxicity , Pilot Projects , Fundulidae/genetics , Gene Expression/drug effects , Superoxide Dismutase/metabolism , Liver/metabolism , Liver/drug effects , Brazil , Gills/metabolism , Killifishes

ABSTRACT

Subject(s)

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