1.
Chem Commun (Camb)
; 53(36): 5024-5027, 2017 May 02.
Article
in English
| MEDLINE
| ID: mdl-28429026
ABSTRACT
The N-difluoromethyl triazolo-ß-aza-ε-amino acid present in the core of peptides led to constrained conformations due to CH-F and NH-F interactions. Pseudotetrapeptides were obtained in excellent yields directly by click chemistry between azidodifluoroacetamides and alkynes, both linked to an amino acid. This work demonstrates that the N-difluoromethyltriazole scaffold can induce extended structures to ß-strand mimics.