ABSTRACT
Diabetes mellitus (DM) is one of the most common metabolic disorders. DM is characterized by hyperglycaemia, resulting in wound healing difficulties and systemic and oral manifestations, which have a direct effect on dental pulp integrity. Experimental and clinical studies have demonstrated a higher prevalence of periapical lesions in patients with uncontrolled diabetes. The influence of DM on periapical bone resorption and its impact on dental intervention of such patients are reviewed, and its aetiology and pathogenesis are analysed at molecular level. Pulps from patients with diabetes have the tendency to present limited dental collateral circulation, impaired immune response, increased risk of acquiring pulp infection (especially anaerobic ones) or necrosis, besides toothache and occasional tendency towards pulp necrosis caused by ischaemia. In regard to molecular pathology, hyperglycaemia is a stimulus for bone resorption, inhibiting osteoblastic differentiation and reducing bone recovery. The relationship between poorly controlled diabetes and bone metabolism is not clearly understood. Molecular knowledge about pulp alterations in patients with diabetes could offer new therapeutic directions. Knowledge about how diabetes affects systemic and oral health has an enduring importance, because it may imply not only systemic complications but also a higher risk of oral diseases with a significant effect on pulp and periapical tissue.
Subject(s)
Diabetes Complications , Periapical Periodontitis/complications , Pulpitis/complications , Alveolar Bone Loss/complications , Diabetes Complications/blood , Diabetes Complications/physiopathology , Humans , Hyperglycemia/complications , Risk Factors , Root Canal TherapyABSTRACT
Diversity and biomass of Chironomidae larvae were studied between January-November 1993 and March-November 1994 in an impacted lagoon in Rio de Janeiro, Southeastern Brazil, in an attempt to establish the ecological consequences of anthropogenic eutrophication processes. Nine hundred and seventy-five organisms belonging to the Tanypodinae, Orthocladiinae, and Chironominae were collected. Polypedilum (62%) and Chironomus (58%) were the most common genera found in the limnetic and littoral zones.
Subject(s)
Diptera/classification , Animals , Biomass , Brazil , Larva , Population DensityABSTRACT
Diversity and biomass of Chironomidae larvae were studied between January-November 1993 and March-November 1994 in an impacted lagoon in Rio de Janeiro, Southeastern Brazil, in an attempt to establish the ecological consequences of anthropogenic eutrophication processes. Nine hundred and seventy-five organisms belonging to the Tanypodinae, Orthocladiinae, and Chironominae were collected. Polypedilum (62 percent) and Chironomus (58 percent) were the most common genera found in the limnetic and littoral zones
Subject(s)
Animals , Diptera , Biomass , Brazil , Larva , Population DensityABSTRACT
A clinical and epidemiological study of 267 cases of envenomation by Loxosceles spp. (loxoscelism), notified to Centro de Informações Toxicológicas de Florianópolis (Santa Catarina State, Brazil), was conducted between January 1985 and December 1995. Most of the incidents occurred along the coast of the mid-southern region of the state, during the warmest months. L. laeta and L. intermedia were identified as the causative agents. Cutaneous loxoscelism was clinically diagnosed in 232 (86.9%) patients with local pain (86.5%), oedema (80.5%), hyperaemia (79.8%) and necrosis (56.9%). Cutaneous-visceral loxoscelism was detected in 35 patients (13.1%) with intravascular haemolysis, manifested by jaundice (68.6%), oliguria (45.7%), dark urine (28.6%), haemorrhage (25.7%), anuria (8.6%) and shock (2.9%), besides the cutaneous effects. Specific antivenom was given to 125 patients (46.8%) and only 8 (6.5%) had mild reactions. Acute renal failure was observed in 17 cases (6.4%); 4 patients (1.5%) died, all of whom were children under 14 years old.
