ABSTRACT
BACKGROUND: The effect of red blood cell (RBC) transfusion on mortality after lung transplantation (LT) was assessed in some retrospective studies, with contradictory results. The first aim of this study was to assess the 90-day survival of LT recipients according to massive intraoperative transfusion (MIOT). METHODS: This prospective, observational, single-centre study analysed the intraoperative transfusion (IOT) of all consecutive LT recipients between January 2016 and February 2019. MIOT was defined as transfusion of 5 RBC units or more. The results are presented as the median [IQR] and absolute numbers (proportions) and were analysed using χ2, Fisher, and Mann-Whitney tests (p < 0.05 as significance). Multivariate analyses were performed to identify independent risk factors for MIOT, 90-day and one-year mortality and grade 3 PGD at day 3. Ninety-day and one-year survivals were studied (Kaplan-Meier curves, log rank test). The Paris-North-Hospitals Institutional Review Board approved the study. RESULTS: Overall, 147 patients were included in the analysis, 27 (18%) of them received MIOT. In multivariate analysis, predictive factors of MIOT included preoperative ECMO support (p = 0.017), and bilateral LT (p = 0.023). The SOFA score on ICU admission after LT was higher in cases with MIOT (p < 0.001). MIOT was an independent risk factor for 90-days and one-year mortality (p = 0.002 and 0.008 respectively). The number of RBCs unit transfused during surgery was an independent risk factor for grade 3 PGD at day 3 (OR 1.14, 95% CI [1.00-1.29], p = 0.040). CONCLUSION: Increased preoperative severity of recipients predicts MIOT. MIOT is associated with increased early postoperative morbidity and mortality rates.
Subject(s)
Erythrocyte Transfusion , Lung Transplantation , Blood Transfusion , Erythrocyte Transfusion/adverse effects , Humans , Prospective Studies , Retrospective Studies , Risk FactorsABSTRACT
A definição de saúde, adotada pela Organização Mundial da Saúde (OMS), indica que muitos fatores influenciam a higidez humana, dentre os quais a qualidade dos serviços de saúde. O artigo apresenta uma visão geral sobre a gestão de serviços, abordando seus componentes, sua finalidade e seus instrumentos. São também comentados os entraves à gestão da qualidade, no Brasil, cujos beneficiários são os usuários dos serviços, os profissionais que neles atuam e a respectiva Administração
