[Effect of losartan, lisinopril and their combination on hemodynamics and morphofunctional parameters of the heart in patients with chronic cardiac failure].

The aim of the study was to evaluate effects of losartan receptor I antagonist (AT) and/or angiotensin converting enzyme inhibitor (iACE) on clinical manifestations of the disease, hemodynamic characteristics, morphofunctional heart parameters in patients with chronic cardiac insufficiency (CHI) complicating coronary heart disease (CHD). A total of 60 patients aged 48-72 (mean 62 +/- 8.4) years with persistent symptoms of functional class II-IV CHI and left ventricular (LV) fraction = < 45% complicating CHD. They were divided into 3 groups of 20 patients each. Patients in group 1 were given losartan (50 mg daily), in group 2 lisinopril (10 mg daily), in group 3 combination of the two drugs for 24 weeks. Combined treatment produced more significant improvement of CHI symptoms than monotherapy with either drug. In all cases, the size of heart left chambers decreased while contractility of left ventricular myocardium increased but these effects were more pronounced after combined therapy.

[Effect of prednisolone, hyperbaric oxygenation and their combination on the glucose content of the blood and glycogen in the organs of white rats]. / Vliianie prednizolona, giperbaricheskoi oksigenatsii i ikh sochetaniia na soderzhanie gliukozy v krovi i glikogena v organakh belykh krys.

A single injection of prednisolone in doses of 10, 30, 80 and 100 mg/kg provoked different shifts in blood glucose concentration and glycogen content in the heart, liver, and skeletal muscles. Prednisolone increased liver glycogen content almost in all the doses. Administered in doses of 10 and 30 mg/kg the drug reduced blood glucose level and glycogen content in the myocardium and skeletal muscles. Administered in doses of 80 and 100 mg/kg the drug produced almost no effect on the characteristics under consideration or increased them. Oxygen raised glycogen liver content, blood glucose level, reduced the content of the polysaccharide in the skeletal muscles at a pressure of 3039 Pa (3 at. abs). Combined use of prednisolone and oxygen at an elevated pressure led, depending on the drug dose, to the occurrence of the phenomena of either synergism or antagonism.