Comparative analysis of the response of microcirculation parameters and blood pressure to geomagnetic activity in healthy people.

We analyze the results of daily laser Doppler flowmetry monitoring of blood microcirculation parameters in 9 healthy volunteers performed in 2006-2009. Dependence of microcirculation and BP parameters on geomagnetic activity was analyzed separately in each volunteer (the influence of ambient temperature was previously excluded). Significantly increased parameters of microcirculation in response to higher geomagnetic activity were found in 4 volunteers (44%) and elevated BP in 1 volunteer; in other cases, no reaction was detected. It was shown that individual sensitivity to geomagnetic activity is proportional to its mean level during the period of measurement. Since blood perfusion volume in tissues directly depends on peripheral vascular resistance, we can conclude that under conditions of high geomagnetic activity microvascular tone varies to a greater extent than the tone of major vessels.

[Pharmacodynamics of nonessential amino acids in elderly patients with post-infarction cardiac sclerosis]. / Farmakodinamika zamenimykh aminokislot u pozhil'nykh bol'nykh postinfarktnym kardiosklerozom.

We studied pharmacodynamics of an amino acids complex (AAC) in 60 elderly patients (a mean age 71.6 years) with ischemic heart disease, postinfarction cardiosclerosis (PIC), circulatory insufficiency stage I-II. The patients were randomized into 3 groups, 20 persons each. Group 1 received standard therapy (ST) and placebo, group 2--ST + AAC (one tablet of 70 mg 3 times a day), group 3--ST + AAC sublingually in the same dose. Clinical symptoms, results of ECG Holter monitoring and echocardiography were assessed before the treatment and on treatment day 18. Positive effects of AAC used in combination with ST in relation to clinical symptoms, myocardial contractility and ischemia. No differences in efficacy were observed with oral and sublingual AAC administration.

[Blood lipids and intensity of free radical oxidant processes in elderly patients with ischemic heart disease on antiatherogenic vegetarian diet]. / Lipidy krovi i intensivnost' svobodnoradikal'nykh okislitel'nykh protsessov u bol'nykh ishemicheskoi bolezn'iu serdtsa pozhilogo vozrasta na fone antiaterogennoi vegetarianskoi diety.

The authors studied the effects of balanced antiatherogenic vegetarian diet enriched with soya bean products on blood lipids and intensity of free radical oxidant processes in elderly patients with ischemic heart disease. 45 patients with dyslipoproteinemia type IIA or IIB were examined for hemodynamic parameters, lipid spectrum and intensity of free radical oxidation. The diet promoted a trend to normalization of central hemodynamics, significantly reduced the level of atherogenic lipids in blood, improved free radical lipid peroxidation and activity of nonenzymatic antioxidant defence.

[Comparative efficacy of combined therapy with preductal and amino acid composition in elderly patients with coronary heart disease and class II-III angina]. / Sravnitel'naia éffektivnost' kompeksnoi terapii s vkliucheniem preduktala i kompozitsii aminokislot u bol'nykh ishemicheskoi bolezn'iu serdtsa so stenokardiei II-III funktsional'nykh klassov pozhilogo vozrasta.

AIM: A comparative analysis of effectiveness of combined therapy including trimetazidine (preductal) and composition of amino acids (glutamic acid, glycin and cystein) in elderly patients with coronary heart disease and angina of functional class II-III (FC II-III). MATERIALS AND METHODS: 60 patients (47 females and 13 males, mean age 66.4 +/- 0.5 years) with IHD, angina FC II-III, postinfarction cardiosclerosis and circulatory failure stage I-IIA were randomized into 3 randomized groups. Control patients received conventional antianginal therapy with nitrates, beta-adrenoblockers, calcium antagonists, diuretics, ACI inhibitors, cardiac glycosides and aspirin. Patients of group 1 received conventional treatment + complex of amino acids in dose 100 mg 3 times a day sublingually. Group 2 patients received adjuvant preductal for 20 days in dose 20 mg 3 times a day per os. Assessment was made clinically, with echo-CG data, bimanual isometric loading and Holter 24-h ECG monitoring. RESULTS: All the three methods showed antianginal, hypotensive effects, brought higher tolerance to exercise and improvement of hemodynamics. The basic therapy produced the least effect. CONCLUSION: Metabolic therapy with amino acids and preductal combined with conventional methods brings more pronounced antianginal and hemodynamic effects than combined therapy alone.

[Betacap efficiency in elderly patients with coronary heart disease and essential hypertension]. / Otsenka éffektivnositi betaképa u pozhilykh bol'nykh gipertonicheskoi bolezn'iu i ishemicheskoi bolezn'iu serdtsa.

AIM: To assess the efficacy of long-acting propranolol in elderly patients with essential hypertension (EH) and coronary disease (CD). MATERIALS AND METHODS: Sixteen patients (mean age 60 years) with EH and CD were examined using ECG and echoCG, chest rheoplethysmography, Holter ECG monitoring, and exercise test. Betacap was administered once a day in doses 40 or 80 mg at 10.00 or 13.00. RESULTS: The drug exerted an antianginal and hypotensive effect. Energy expenditures of the myocardium decreased and exercise tolerance improved; the drug was more effective in patients with the hyperkinetic circulation and if taken at 10.00. CONCLUSION: Betacap is an effective antianginal and hypotensive agent, recommended for therapy of elderly patients with EH and CD.

[Comparative study of the effectiveness of Cozaar monotherapy and Cozaar and melatonin combined therapy in aged patients with hypertension]. / Sravnite'naia otsenka éffektivnosti monoterapii kozaarom i sochetannoi terapii kozaarom i melatoninom bol'nykh pozhilogo vozrastas gipertonicheskoi bolezn'iu.

Effectiveness of Cozaar monotherapy (50 mg at 8 a.m.) was compared to that of Cozaar combination with melatonin (3 mg before sleep) in 21 patients with hypertension stage II (mean age 62 years). Clinical symptoms and hemodynamic parameters were evaluated with ECG and blood pressure monitoring. The findings were processed with statistical methods and Kosinor-analysis. Cozaar alone had moderate hypotensive and vasodilating effects, affected circadian rhythm of systolic and diastolic blood pressure, heart rate. Combination Cozaar + melatonin reduced blood pressure more noticeably, diminished cardiac output, energy consumption of the myocardium, normalized normal chronostructure of blood pressure and heart rate circadian rhythms.

[Cardicap treatment of ischemic heart disease in aged patients]. / Kardikep v lechenii bol'nykh ishemicheskoi bolezn'iu serdtsa pozhilogo vozrasta.

The paper presents the results obtained in the study of efficacy of a new antianginal drug cardicap, a long acting isosorbide dinitrate (Natko, India). Changes in the clinical symptoms, exercise tolerance, ECG monitoring and echo-CG parameters in 27 patients (mean age 63 years) with ischemic heart disease, class II and III angina pectoris enable the conclusion on marked antianginal, vasodilatating effect of cardicap, on a rise in the exercise tolerance, reduction in the myocardial power consumption. The effect of cardicap was time-related.

[Experience in the use of eiconol (a complex of unsaturated fatty acids) in non-insulin-dependent diabetes mellitus]. / Opyt ispol'zovaniia éikonola (kompleksa nenasyshchennykh zhirnykh kislot) pri insulinezavisimom sakharnom diabete.

Cardiovascular disease is the principal cause of morbidity, functional disability and fatal outcomes in patients with non-insulin-dependent diabetes mellitus (NIDDM). The results of administration of eikonol, food additive containing omega-3 unsaturated fatty acids, for 3 months were analyzed for 60 elderly NIDDM patients with ischemic heart disease. A single administration of eikonol leads to a decrease in accumulation of intracellular cholesterol by 15%. Diet eikonol decreased the level of total cholesterol and triglycerides in the blood by 23 and 43%, respectively. Moreover, the higher is the initial value of these parameters, the higher is the effect of the preparation. Eikonol proved to increase the level of lipoproteins of high density, produced a positive trends in NIDDM clinical picture. Food additive eikonol is recommended for wide administration in elderly NIDDM patients with atherogenic dyslipidemias.

[Chronopharmacodynamics of delayed-action cardiac glycosides and nitrates]. / Khronofarmakodinamika serdechnykh glikozidov i nitratov prolongi- rovannogo deistviia.

In 96 patients with coronary heart disease and stage II circulatory failure, the chronopharmacodynamics of strophanthin, corglycon, and nitrosorbide was studied by using acute clinical and pharmacological tests in the morning (8.00 a.m.), in the afternoon (2.00 p.m.), and in the evening (8.00 p.m.). Central and peripheral hemodynamic parameters were measured prior to and following 5, 15, 30, 60, and 120 min of intravenous injection of cardiac glycosides or sublingual administration of nitrosorbide in a dose of 10 mg for 240 min. The investigations showed that there were the most profound hemodynamic changes in the morning if strophanthin was used and in the afternoon if corglycon was given. The maximal reduction in heart pre- and afterload was seen in the morning when nitrosorbide was applied, the most improvement in central hemodynamic parameters was observed in the evening when nitrosorbide was used.