ABSTRACT
The aim of this study was to determine the reference interval of serum cobalt-binding capacity (CoBC) and to estimate the effect of factors unrelated to oxidative modification of serum albumin on this diagnostic marker. A group of healthy volunteers (n=194), a group of patients with autoimmune diseases (n=44) and a group of patients with diabetes type 2 (n=50) participated in this study. The regional reference interval was found to be 0,462-0,744 mmol Co 2+ /l of serum. The study of serum CoBC in two groups of patients showed that the CoBC level strongly depends on the serum protein profile. Therefore, this diagnostic test may be used for diagnosing ischemia, but other pathologies associated with changes in a ratio of blood protein fractions can also influence the serum CoBC level.
Subject(s)
Arthritis, Rheumatoid/blood , Blood Proteins/metabolism , Cobalt/blood , Diabetes Mellitus, Type 2/blood , Purpura, Thrombocytopenic, Idiopathic/blood , Adolescent , Adult , Aged , Arthritis, Rheumatoid/diagnosis , Biomarkers/blood , Case-Control Studies , Diabetes Mellitus, Type 2/diagnosis , Female , Humans , Male , Middle Aged , Protein Binding , Purpura, Thrombocytopenic, Idiopathic/diagnosis , Reference ValuesABSTRACT
A questionnaire survey of 103 patients with active tuberculosis of the respiratory organs provided evidence on social factors contributing to more frequent onset of destructive tuberculosis, complications, discharge of M. tuberculosis, associated chronic bronchitis and ulcer. These were: serving sentence in prison or reformatory, poverty, alcoholism. X-ray diagnosis of tuberculosis provided earlier detection of the disease reducing the number of complications and invalidity.
Subject(s)
Tuberculosis, Pulmonary/epidemiology , Adult , Alcoholism/complications , Female , Humans , Male , Middle Aged , Poverty , Prisoners , Radiography, Thoracic , Risk Factors , Socioeconomic Factors , Tuberculosis, Pulmonary/diagnosisSubject(s)
Bronchodilator Agents/administration & dosage , Respiratory Therapy , Tuberculosis, Pulmonary/drug therapy , Adult , Aerosols , Albuterol/administration & dosage , Cromolyn Sodium/administration & dosage , Drug Combinations , Female , Fenoterol/administration & dosage , Humans , Ipratropium/administration & dosage , Lung Diseases, Obstructive/drug therapy , Lung Diseases, Obstructive/physiopathology , Male , Middle Aged , Respiratory Function Tests , Tuberculosis, Pulmonary/physiopathologyABSTRACT
Effect of neutral polymers on activity of tyrosine aminotransferase and hydrocortisone induction of the enzyme were studied. Physiologically active polymers decreased in most cases the basal rate of the enzymatic activity. Preadministration of polymers decreased hormonal induction of tyrosine aminotransferase. Simultaneous administration of polymers and hydrocortisone led to augmented and long-term induction, which appears to occur due to complex-formation of the polymer and hormone. Gradual liberation of hydrocortisone from the complex enabled to maintain the hormone effective concentration for a long time.
Subject(s)
Hydrocortisone/physiology , Polymers , Tyrosine Transaminase/biosynthesis , Animals , Enzyme Induction , Liver/enzymology , MiceABSTRACT
Liposomes prevented the hydrocortisone-produced induction of tyrosine aminotransferase in animal liver tissue under conditions of normal state and of alcohol intoxication. The inhibitory effect of liposomes appears to be mainly based on their ability to incorporate into hepatocyte membranes, due to which the membrane permeability towards hydrocortisone was altered.
Subject(s)
Hydrocortisone/antagonists & inhibitors , Liposomes/pharmacology , Liver/enzymology , Tyrosine Transaminase/biosynthesis , Animals , Cell Membrane Permeability/drug effects , Enzyme Induction/drug effects , Ethanol/pharmacology , Hydrocortisone/pharmacology , Liposomes/metabolism , Liver/drug effects , Liver/metabolism , Membrane Lipids/metabolism , Mice , Mice, Inbred CBAABSTRACT
A total of 63 patients were investigated in order to provide a psychological analysis of schizophrenia-related early childhood autism (ECA). Need and motivation were shown to play a major role in the disordered interpersonal communication characteristic of two types of mental dysontogenies in the pattern of ECA under this investigation. The dysontogeny type showed a relation to the nature and depth of communicative disorder. The ways of its psychological correction targeted at the ECA children's social rehabilitation were outlined.
Subject(s)
Autistic Disorder/etiology , Communication Disorders/etiology , Interpersonal Relations , Schizophrenia, Childhood/complications , Schizophrenic Psychology , Autistic Disorder/psychology , Autistic Disorder/therapy , Child , Child, Preschool , Communication Disorders/psychology , Communication Disorders/therapy , Humans , Psychotherapy, GroupSubject(s)
Bronchitis/drug therapy , Iontophoresis/methods , Adolescent , Adult , Chronic Disease , Drug Evaluation , Drug Therapy, Combination , Humans , Lung , Middle AgedABSTRACT
A study has been made of the effect of ethanol and CCl4 on hormonal induction of tyrosine aminotransferase in mouse liver. Both the hepatotropic poisons administered for a long time lose the induction effect and considerably reduce the same effect exerted by hydrocortisone. Microscopic study has revealed fatty dystrophy of the liver cells and even the formation of the areas of necrosis as a result of administering CCl4. The liver tissue stroma has been shown to develop reactive inflammation.
Subject(s)
Alcoholism/enzymology , Carbon Tetrachloride Poisoning/enzymology , Hydrocortisone/pharmacology , Liver/enzymology , Tyrosine Transaminase/biosynthesis , Alcoholism/pathology , Animals , Carbon Tetrachloride Poisoning/pathology , Chronic Disease , Enzyme Induction/drug effects , Histocytochemistry , Humans , Liver/drug effects , Mice , Mice, Inbred CBAABSTRACT
Repeated administration of ethanol into animals within 14 and 21 days decreased or completely abolished the inducing effect of ethanol on the tyrosine aminotransferase activity (TAT) in liver tissue. At the same time, the inducing effect of hydrocortisone was maintained although at the lower level as compared with the intact animals. Chronic poisoning of the animals with CCl4 within 4 weeks inhibited the inducing effect. As compared with controls the inducing effect of hydrocortisone was distinctly lower in the animals poisoned with CCl4.
Subject(s)
Alcoholism/enzymology , Carbon Tetrachloride Poisoning/enzymology , Hydrocortisone/pharmacology , Liver/enzymology , Tyrosine Transaminase/biosynthesis , Animals , Enzyme Induction , Histidine Ammonia-Lyase/biosynthesis , Humans , Mice , Mice, Inbred CBAABSTRACT
Induction of tyrosine aminotransferase using hydrocortisone was studied after administration of ethanol and CCl4 into animals. Administration of ethanol activated the enzyme. Simultaneous treatment of the animals with ethanol and hydrocortisone decreased 2-fold an inducing effect of the hormone. Within the subsequent periods the tyrosine aminotransferase activity continued to increase, exceeding the initial enzymatic activity induced by hydrocortisone. CCl4 did not affect the induction of the enzyme by hydrocortisone. The treatment with CCl4 showed an inducing effect with an increase in the enzymatic activity by 40% in liver tissue as compared with the initial level.
