ABSTRACT
Characteristic features of the clinical course and immune status were studied in 24 histiocytosis X patients. Immunologic studies were carried out in 15 histiocytosis X patients by the methods that characterize the T- and B-lymphocyte systems, their sensitivity to tuberculin, the receptor apparatus of lymphocytes and neutrophilic granulocytes and autoimmune processes. The immune status of these patients is distinguished by disorders caused by secondary cellular deficit combined with the imbalance of the immunoregulatory cell system. Disorders of the B-cell link of the immune system are less pronounced and there is a drop in the production of natural antibodies and IgM. A high degree of sensitization to tuberculin was detected in the in vivo and in vitro tests, which indirectly testifies to the tuberculous origin of histiocytosis X.
Subject(s)
Histiocytosis, Langerhans-Cell/immunology , Adolescent , Adult , B-Lymphocytes/immunology , Female , Histiocytosis, Langerhans-Cell/diagnosis , Humans , Immunoglobulins/analysis , Male , Middle Aged , Rosette Formation , T-Lymphocytes/immunology , Tuberculin TestABSTRACT
Data are reported of a comparison of the clinico-immunological efficacy of hemo- and enterosorption in the complex treatment of patients with chronic asthmatic bronchitis. It was found that both sorption methods associated with adequate drug treatment produce a pronounced immunocorrective effect but hemosorption normalizes more quickly the functional activity of T-lymphocytes and number of circulating immune complexes while enterosorption normalizes more quickly the number of T-lymphocytes.
Subject(s)
Asthma/therapy , Bronchitis/therapy , Hemoperfusion , Adsorption , Chronic Disease , Combined Modality Therapy , Evaluation Studies as Topic , Humans , MethodsABSTRACT
The criteria of differential administration of thymalin in the combined management of patients with destructive pulmonary tuberculosis were defined on the basis of immunologic studies. A ++clinico-roentgenologic and immunologic evaluation of in-patient treatment of 60 cases demonstrated that a differential administration of thymalin in combination with chemotherapeutic drugs greatly shortened the stay at a hospital and increased the efficacy of treatment. Besides, more evident normalizing influence of the proposed option of therapy on the recovery of the immune system links is noted.
Subject(s)
Adjuvants, Immunologic/administration & dosage , Antitubercular Agents/administration & dosage , Thymus Hormones/administration & dosage , Tuberculosis, Pulmonary/drug therapy , Adolescent , Adult , Drug Therapy, Combination , Female , Humans , Immunocompetence/drug effects , Immunocompetence/immunology , Male , Middle Aged , Tuberculosis, Pulmonary/immunologyABSTRACT
The effect of various doses of rifampicin on intensity of rosette formation was studied, and the immunological criteria for selective use of the drug in combined specific chemotherapy of extended destructive tuberculosis of the lungs were determined. It was shown that differential use of rifampicin with an account of its administration multiplicity and route promoted a decrease in the hospitalization terms and increased rate of discontinuation of tubercle bacilli isolation and cavern healing. The clinicoroentgenological findings were confirmed by the immunological tests characterizing various elements of the immunity system in patients.
