1.
Org Biomol Chem
; 16(28): 5197-5202, 2018 07 18.
Article
in English
| MEDLINE
| ID: mdl-29972191
ABSTRACT
An efficient iodocarbocyclization of alkenes for the synthesis of iodooxindoles has been developed. This reaction proceeds in a chemoselective manner and shows excellent tolerance of various functional groups, including a chemosensitive hydroxymethyl group. Nonmetal inorganic iodine pentoxide was used as both the oxidant and iodine source, making this protocol very practical. On the basis of experimental observations, a plausible electrophilic reaction mechanism was proposed.