Overcoming public resistance to carbon taxes: A cost-efficient solution built on a pre-existing reward-based climate policy.

A carbon tax is effective at curbing carbon emissions, but it is met with low public support due to its high personal cost. Investigations have been conducted to reform carbon tax design to ease the burden on individuals by providing economic compensation, but the cost for governments is high. We propose a new cost-efficient solution by introducing people to a pre-existing reward-based climate policy to create a sense of economic compensation. Across three experiments, we show that the presence of a pre-existing reward-based climate policy increases participants' support for a carbon tax, especially when the innate connection between the two policies is made salient and people regard the reward as compensation for the tax. In contrast, if people are distracted from sensing this interrelationship, support for the tax does not differ from when it is introduced alone. Applicability of this approach was tested under different conditions where the pressure to reduce carbon emission is either high or low.

NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling.

NAD+ levels decline with age and in certain disease conditions. NAD+ precursors have been shown to stimulate NAD+ biosynthesis and ameliorate various age-associated diseases in mouse models. However, NAD+ metabolism is complicated in cancer and its role in triple-negative breast cancer (TNBC) remains elusive. Here, we show that NAD+ supplement suppresses tumor metastasis in a TNBC orthotopic patient-derived xenograft (PDX) model. Sirtuin1 lysine deacetylase (SIRT1) is required for the effects since SIRT1 knockdown blocks NAD+-suppressed tumor metastasis. Overexpression of SIRT1 effectively impairs the metastatic potential of TNBC. Importantly, the interaction between SIRT1 and p66Shc causes the deacetylation and functional inactivation of p66Shc, which inhibits epithelial-mesenchymal transition (EMT). Overall, we demonstrate that NAD+ supplementation executes its anti-tumor function via activating the SIRT1-p66Shc axis, which highlights the preventive and therapeutic potential of SIRT1 activators as effective interventions for TNBC.

Waste sorting behaviors promote subjective well-being: A perspective of the self-nature association.

As one of the most important pro-environmental behaviors, individuals' waste sorting behaviors are positively associated with their subjective well-being. This relationship is usually explained by the "self-other association", regarding waste sorting behaviors as pro-social deeds, thus elevating people's positive self-perception and strengthening a sense of interpersonal relatedness. Distinct from the general "good deeds", the ultimate beneficiary of waste sorting behaviors is the natural environment instead of other people, so the mechanism underlying the positive relationship between performing a general good deed and subjective well-being might not suffice to explain the positive association between waste sorting behaviors and subjective well-being. The current study proposed the "self-nature association" with the cognitive (i.e., environmental perception) and the affective (i.e., nature connectedness) pathways. Using a large sample national survey in China (N = 4,705), we confirmed the positive link between waste sorting behaviors and subjective well-being, and the dual pathway was verified by a parallel mediation analysis. The theoretical and practical values of the present work were further explicated.

Threats of COVID-19 arouse public awareness of climate change risks.

Public climate change awareness is indispensable to dealing with climate change threats. Understanding whether and how the COVID-19 pandemic impacts on individuals' climate change risk perception would thus be critical to green economic recovery. We conducted a longitudinal survey study in China when the pandemic was at its height and when it was mitigated. The cross-lagged analysis confirmed our assumed "arousal" effect of perceived COVID-19 risks on climate change risk awareness. We further tested and verified the proposed "dual-pathway" mechanisms of affective generalization (i.e., negative affective states aroused by COVID-19 "spillover" to the assessment of climate change risk) and cognitive association (i.e., the outbreak of COVID-19 awakens people's recognition of the human-nature-climate issues) via multiple mediation analyses. Our results implied that climate policies could be integrated into pandemic control, and that the public should be more awakened to confront multiple crises with proper guidance.

Effects of Climate Change Knowledge on Adolescents' Attitudes and Willingness to Participate in Carbon Neutrality Education.

The achievement of carbon neutrality has become increasingly important. Therefore, it the use of education to increase public understanding of carbon neutrality and facilitate low-carbon behaviors is urgent. Climate change knowledge is an effective measure to promote people's interest and enthusiasm for specific educational projects. The present study analyzed the effects of climate change knowledge on adolescents' attitudes and their willingness to participate in carbon neutrality education and validated the mediating effect of environmental responsibility. The findings showed that climate change knowledge improves adolescents' attitudes toward carbon neutrality education and that environmental responsibility plays a mediating role in this. The findings provide insightful implications for carbon neutrality related policymaking and education promotion.

The Impact of the Gain-Loss Frame on College Students' Willingness to Participate in the Individual Low-Carbon Behavior Rewarding System (ILBRS): The Mediating Role of Environmental Risk Perception.

Since Chinese households account for more than half of the country's total carbon emissions, efforts focused on consumption will be key to reaching carbon reduction targets. The Individual Low-carbon Behavior Rewarding System (ILBRS) is an emerging mechanism in China that encourages the public to develop a low-carbon lifestyle and it is critical to look for various approaches to enhance the public's willingness to participate in it. The framing effect has been widely used to study pro-environmental behavior as a low-cost nudge. We used an online questionnaire (N = 320) to investigate how framing information (loss and gain framing) influenced people's willingness to participate in the ILBRS through the mediation of environmental risk perception. The results indicated that the public's willingness to participate in the ILBRS under the loss frame was significantly higher than the gain frame. Furthermore, environmental risk perception played a mediating role in the proceedings. Based on our findings, the designers and promoters of ILBRS systems could employ loss-frame information to promote the public's willingness to participate in the ILBRS and drive more people to live a low-carbon life in the process of mechanism construction, information communication, and operational promotion.

Gender-Related Beliefs, Norms, and the Link With Green Consumption.

Although extant literature provided abundant evidence that men and women are different in their environmental behaviors, there is a lack of integration of gender differences in green consumption and the underlying mechanism that associates with these disparities. Therefore, to solve this existing gap, the current paper reviewed existing literature on green consumption with threefold purposes. First, presenting an integrated view of gender-different green consumption patterns along with the relationship of gender-related beliefs and individuals' pro-environmental behavior based on existing evidence. Second, interpreting how gender differences are generated based on the value-belief-norm (VBN) theory, and the theory of social roles. Third, analyzing previous studies, providing implications for future research, and then proposing suggestions for marketing practitioners in the green products industry. Accordingly, this article compared men's and women's different behavior in green consumption and discussed how and why they behave differently. Generally, women show a more positive green consumption intention, consume less carbon, and purchase green products more frequently. Whereas men are doing better than women in terms of environmental knowledge, and in some regions, they express higher concerns about environmental problems. It interprets individual differences in green consumption based on VBN theory from a unique insight-gender. It also identified some barriers for both men and women to participate in green consumption, and then proposed several suggestions to improve the public willingness of engaging in green consumption.

More than just a mental stressor: psychological value of social distancing in COVID-19 mitigation through increased risk perception-a preliminary study in China.

Social distancing is an effective measure to prevent epidemic infections during a pandemic outbreak, but its psychological value in COVID-19 pandemic mitigation remained less detected. Our study fills this gap by conducting a nationwide survey in China between 12 and 25 February (2020), and a follow-up survey targeting the same participants between 25 and 28 March (2020). We have discovered that perceived increased time staying at home, a subjective agency for social distancing, positively predicts not only risk perception of COVID-19 epidemic at the outbreak and eased stage, but also predicts subjective controllability of COVID-19 epidemic at the eased stage. Given that risk perception indicates potential active engagement of preventative behavior and that subjective controllability associating with self-efficacy could promote individual health behavior, this study preliminarily justifies the value of social distancing from the angle of perceptual factors, adding to existing mounting evidence of its effect on physically controlling pandemic spread.

Correction: More than just a mental stressor: psychological value of social distancing in COVID-19 mitigation through increased risk perception-a preliminary study in China.

[This corrects the article DOI: 10.1057/s41599-021-00774-1.].

Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice.

Improvement of longevity is an eternal dream of human beings. The accumulation of protein damages is considered as a major cause of aging. Here, we report that the injection of exogenous recombinant mouse serum albumin (rMSA) reduced the total damages of serum albumin in C57BL/6N mice, with higher level of free-thiols, lower levels of carbonyls and advanced glycation end-products as well as homocysteines in rMSA-treated mice. The healthspan and lifespan of C57BL/6N mice were significantly improved by rMSA. The grip strength of rMSA-treated female and male mice increased by 29.6% and 17.4%, respectively. Meanwhile, the percentage of successful escape increased 23.0% in rMSA-treated male mice using the Barnes Maze test. Moreover, the median lifespan extensions were 17.6% for female and 20.3% for male, respectively. The rMSA used in this study is young and almost undamaged. We define the concept "young and undamaged" to any protein without any unnecessary modifications by four parameters: intact free thiol (if any), no carbonylation, no advanced glycation end-product, and no homocysteinylation. Here, "young and undamaged" exogenous rMSA used in the present study is much younger and less damaged than the endogenous serum albumin purified from young mice at 1.5 months of age. We predict that undamaged proteins altogether can further improve the healthspan and lifespan of mice.

Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner.

Metformin has been documented in epidemiological studies to mitigate tumor progression. Previous reports show that metformin inhibits tumor migration in several cell lines, such as MCF-7 and H1299, but the mechanisms whereby metformin exerts its inhibitory effects on tumor metastasis remain largely unknown. The secreted proteins in cancer cell-derived secretome have been reported to play important roles in tumor metastasis, but whether metformin has an effect on tumor secretome remains unclear. Here we show that metformin inhibits tumor metastasis by suppressing Hsp90α (heat shock protein 90α) secretion. Mass spectrometry (MS) analysis and functional validation identify that eHsp90α (extracellular Hsp90α) is one of the most important secreted proteins for metformin to inhibit tumor cells migration, invasion and metastasis both in vitro and in vivo. Moreover, we find that metformin inhibits Hsp90α secretion in an AMPKα1 dependent manner. Our data elucidate that AMPKα1 (AMP-activated protein kinase α1) decreases the phosphorylation level of Hsp90α by inhibiting the kinase activity of PKCγ (protein kinase Cγ), which suppresses the membrane translocation and secretion of Hsp90α. Collectively, our results illuminate that metformin inhibits tumor metastasis by suppressing Hsp90α secretion in an AMPKα1 dependent manner.