ABSTRACT
Classic radiological signs of invasive fungal disease, especially pulmonary mucormycosis in a predisposed individual should alert the physician to initiate empiric anti-fungal therapy. https://bit.ly/40gt4Hm.
ABSTRACT
Good's syndrome or thymoma-associated immunodeficiency is a rare clinical entity that is often presumed to be common variable immunodeficiency, due to lack of awareness and recognition of this syndrome. This syndrome more often goes unrecognized if a thymoma is not detected. An appropriate immunological work-up that aids timely diagnosis and adequate therapy with antimicrobials and intravenous immunoglobulins are mandatory to prevent the long-term complications and mortality associated with this syndrome. We present the clinical and immunological profile of a young man with Good's syndrome that was initially presumed to be common variable immunodeficiency.
Subject(s)
Agammaglobulinemia/diagnosis , Common Variable Immunodeficiency/diagnosis , Thymoma/diagnosis , Thymus Neoplasms/diagnosis , Agammaglobulinemia/immunology , Agammaglobulinemia/therapy , Anti-Infective Agents/therapeutic use , Common Variable Immunodeficiency/immunology , Diagnostic Errors , Humans , Immunoglobulins, Intravenous/therapeutic use , Magnetic Resonance Imaging , Male , Middle Aged , Predictive Value of Tests , Syndrome , Thymectomy , Thymoma/complications , Thymoma/immunology , Thymoma/surgery , Thymus Neoplasms/complications , Thymus Neoplasms/immunology , Thymus Neoplasms/surgery , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
A 66-year-old man presented with dry cough and shortness of breath on exertion of 6 months' duration. There were no complaints of fever and hemoptysis. His history was significant for recurrent episodes of respiratory tract infections over the previous 4 years. He had also had episodes of recurrent otitis media and pus discharge from the left ear for 3 years, with progressive loss of hearing. There was no history of recurrent skin infections or diarrhea. He was treated symptomatically with antibiotics by local general practitioners. He was a nonsmoker and did not drink alcohol, and there was no history of environmental or occupational exposure. He had been known to have diabetes for 10 years. He had negative results for the presence of HIV and hepatitis B surface antigen.
