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1.
Chem Commun (Camb) ; 52(69): 10582, 2016 Sep 07.
Article in English | MEDLINE | ID: mdl-27502077

ABSTRACT

Correction for 'Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms' by Jiaul Hoque et al., Chem. Commun., 2015, 51, 13670-13673.

2.
Chem Commun (Camb) ; 51(71): 13670-3, 2015 Sep 14.
Article in English | MEDLINE | ID: mdl-26226319

ABSTRACT

Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the biofilms. Moreover, this class of membrane-active molecules disarms the development of bacterial resistance.


Subject(s)
Bacteria/drug effects , Biofilms/drug effects , Drug Resistance/drug effects , Small Molecule Libraries/pharmacology , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , HEK293 Cells , Humans , Microbial Sensitivity Tests , Microscopy, Fluorescence , Molecular Structure , Small Molecule Libraries/chemistry
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