1.
Bioorg Med Chem Lett
; 10(3): 231-4, 2000 Feb 07.
Article
in English
| MEDLINE
| ID: mdl-10698442
ABSTRACT
(6R)- and (6S)-6-Fluoro-3-dehydroquinic acids are shown to be substrates for type I and type II dehydroquinases. Their differential reactivity provides insight into details of the reaction mechanism and enables a novel enzyme-substrate imine to be trapped on the type I enzyme.
Subject(s)
Cyclohexanecarboxylic Acids/metabolism , Cyclohexanones/metabolism , Hydro-Lyases/metabolism , Isoenzymes/metabolism , Magnetic Resonance Spectroscopy , Mass Spectrometry , Mycobacterium tuberculosis/enzymology , Stereoisomerism
2.
Biochem J
; 319 ( Pt 2): 333-6, 1996 Oct 15.
Article
in English
| MEDLINE
| ID: mdl-8912664
