Subject(s)
Kidney Neoplasms/pathology , Wilms Tumor/pathology , Age Factors , Child , Child, Preschool , Combined Modality Therapy , Female , Humans , Infant , Kidney Neoplasms/therapy , Lymphatic Metastasis , Male , Neoplasm Invasiveness , Neoplasm Recurrence, Local , Prognosis , Wilms Tumor/therapyABSTRACT
The results of 14 cases of Wilms tumor, treated according to the SIOP, nephroblastoma trial and study protocols, are presented. Later, an up to date review of the state of knowledge on the problem is done, mainly in relation to histology, treatment and prognosis.
Subject(s)
Kidney Neoplasms/pathology , Wilms Tumor/pathology , Child , Child, Preschool , Female , Humans , Infant , Kidney Neoplasms/therapy , Male , Neoplasm Metastasis , Neoplasm Recurrence, Local , Prognosis , Wilms Tumor/therapyABSTRACT
Nine children with acute lymphoblastic leukemia or lymphosarcoma adquired varicella and were treated with cytosine arabinoside. There was a progression of the varicellous lesions which in some cases became hemorrhagic. In four occasions disease became disseminated. Two children died. The hematologic toxicity was tolerable.
Subject(s)
Chickenpox/drug therapy , Cytarabine/therapeutic use , Leukemia, Lymphoid/drug therapy , Lymphoma, Non-Hodgkin/drug therapy , Body Weight , Chickenpox/complications , Child , Child, Preschool , Clinical Trials as Topic , Cytarabine/administration & dosage , Drug Evaluation , Humans , Infant , Injections, Intravenous , Leukemia, Lymphoid/complicationsABSTRACT
Therapeutic protocol and treatment results of 27 children with acute lymphoblastic leukemia are described. A remission rate of 88 per 100 was obtained. Fourteen children are living. Five of those followed for two or more years are living (35 per 100). The prophylaxis of leukemic meningitis was done with intrathecal Methotrexate. Only one child treated in this manner developed leukemic meningitis. Infection was the most frequent cause of death.
Subject(s)
Leukemia, Lymphoid/drug therapy , Methotrexate/therapeutic use , Child , Child, Preschool , Humans , Injections, Spinal , Meningitis/drug therapy , Methotrexate/administration & dosage , Remission, SpontaneousABSTRACT
A case of acute lymphoblastic leukemia that appeared as hypercalcemia with radiologic osseous abnormalities and back pain is described. Pathophysiologic mechanisms of hypercalcemia and treatment are reviewed. After initial treatment with phenobarbital and saline solutions, followed by specific treatment for the leukemic process, hypercalcemia descended to normal values.
